Auger electron therapy of glioblastoma using [125I]5-Iodo-2’-deoxyuridine and concomitant chemotherapy – evaluation of a potential treatment strategy

2021 ◽  
Author(s):  
Karina Lindbøg Madsen ◽  
Anne Sofie Nautrup Therkelsen ◽  
Niels Langkjær ◽  
Birgitte Brinkmann Olsen ◽  
Helge Thisgaard
Keyword(s):  
Treatment Strategy ◽  
Auger Electron ◽  
Potential Treatment ◽  
Concomitant Chemotherapy ◽  
Electron Therapy

The Potentially Modifiable Risk Factor in Idiopathic Intracranial Hypertension: Body Weight

2021 ◽  
pp. 10.1212/CPJ.0000000000001063
Author(s):  
Susan P Mollan ◽  
Abd A Tahrani ◽  
Alexandra J Sinclair
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Risk Factor ◽  
Intracranial Pressure ◽  
Intracranial Hypertension ◽  
Treatment Strategy ◽  
Idiopathic Intracranial Hypertension ◽  
Potential Treatment ◽  
Distal Small Intestine

AbstractPurpose of review:Idiopathic intracranial hypertension (IIH) prevalence increased in conjunction with rising obesity rates. Here, we highlight the importance of weigh management in IIH, and introduce glucagon-like peptide 1 (GLP-1) receptor agonists (RA) as potential treatment strategy for IIH.Recent findings:Weight gain is a risk factor for IIH; and weight loss (via any treatment strategy) plays a key role in IIH management. GLP-1 is an incretin secreted by the distal small intestine in response to a meal. GLP-1 RA have been shown to improve glycaemic control (no. hypoglycaemia) and lower body weight in patients with and without type 2 diabetes. The choroid plexus has been found to express GLP-1 receptors and treatment with a GLP-1 RA significantly reduces cerebrospinal fluid secretion in vitro and intracranial pressure in rodents.Summary:New research evaluating the pathophysiology of IIH supports GLP-1 RA as a potential treatment for IIH via weight loss dependant and independent mechanism to directly reduce intracranial pressure.

scholarly journals 165Er: A new candidate for Auger electron therapy and its possible cyclotron production from natural holmium targets

2020 ◽  
Vol 159 ◽  
pp. 109079
Author(s):  
Nadezda Gracheva ◽  
Tommaso Stefano Carzaniga ◽  
Roger Schibli ◽  
Saverio Braccini ◽  
Nicholas P. van der Meulen
Keyword(s):  
Auger Electron ◽  
Cyclotron Production ◽  
Electron Therapy

WE-E-BRE-08: Impact of IUdR in Rat 9L Glioma Cell Survival for 25-35 KeV Photo-Activated Auger Electron Therapy

2014 ◽  
Vol 41 (6Part29) ◽  
pp. 505-505 ◽  
Author(s):  
D Alvarez ◽  
K Hogstrom ◽  
T Brown ◽  
J Dugas ◽  
K Matthews ◽  
...  
Keyword(s):  
Cell Survival ◽  
Glioma Cell ◽  
Auger Electron ◽  
Electron Therapy ◽  
9L Glioma

scholarly journals Prebiotics: A Potential Treatment Strategy for the Chemotherapy-damaged Gut?

2014 ◽  
Vol 56 (6) ◽  
pp. 946-956 ◽  
Author(s):  
Hanru Wang ◽  
Mark S. Geier ◽  
Gordon S. Howarth
Keyword(s):  
Treatment Strategy ◽  
Potential Treatment
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