Serum levels of adhesion molecules ICAM-1 and VCAM-1 and tissue inhibitor of metalloproteinases, TIMP-1, are elevated in patients with autoimmune thyroid disorders: Relevance to vascular inflammation

Gastric carcinoma is reported to be more frequent in geographical areas where diets are either iodine-deficient or iodine-excessive. Reports have also shown an association between thyroid diseases and some of the risk factors for gastric carcinoma. We investigated the frequency of thyroid disorders in 61 patients with gastric carcinoma compared with 55 healthy control subjects. Thyroid health was evaluated by physical examination and by measuring the serum levels of thyroid hormones and thyroid autoantibodies. More patients with gastric cancer had goitre compared with healthy controls (49.1% versus 20%, respectively). Significantly more patients with gastric cancer had non-toxic goitre compared with control subjects. There was also a significant difference in the incidence of autoimmune thyroid disease −27.8% of patients with gastric cancer versus 10.9% of control subjects were affected. These results indicate that there is a significant association between gastric cancer and thyroid disorders.

Download Full-text

Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis

Arthritis & Rheumatism ◽

10.1002/1529-0131(200110)44:10<2263::aid-art389>3.0.co;2-1 ◽

2001 ◽

Vol 44 (10) ◽

pp. 2263-2274 ◽

Cited By ~ 73

Author(s):

Gaye Cunnane ◽

Oliver FitzGerald ◽

Charlotte Beeton ◽

Tim E. Cawston ◽

Barry Bresnihan

Keyword(s):

Rheumatoid Arthritis ◽

Matrix Metalloproteinase ◽

Serum Levels ◽

Tissue Inhibitor Of Metalloproteinases ◽

Tissue Inhibitor ◽

Matrix Metalloproteinase 3 ◽

Matrix Metalloproteinase 1 ◽

Joint Erosions

Download Full-text

Serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in human herpesvirus-6–infected infants with or without febrile seizures

Journal of Infection and Chemotherapy ◽

10.1016/j.jiac.2014.07.017 ◽

2014 ◽

Vol 20 (11) ◽

pp. 716-721 ◽

Cited By ~ 8

Author(s):

Setsuaki Kittaka ◽

Shunji Hasegawa ◽

Yoshinori Ito ◽

Noriko Ohbuchi ◽

Eitaro Suzuki ◽

...

Keyword(s):

Matrix Metalloproteinase ◽

Human Herpesvirus ◽

Febrile Seizures ◽

Serum Levels ◽

Matrix Metalloproteinase 9 ◽

Tissue Inhibitor Of Metalloproteinases ◽

Human Herpesvirus 6 ◽

Tissue Inhibitor ◽

Herpesvirus 6 ◽

Metalloproteinase 9

Download Full-text

Relationship between Serum Levels of Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinases-1 and Exercise Test Results in Postmenopausal Women

Disease Markers ◽

10.1155/2016/7169531 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

J. Mieczkowska ◽

E. Rutkowska ◽

J. Mosiewicz ◽

B. Mosiewicz

Keyword(s):

Physical Activity ◽

Exercise Test ◽

Serum Levels ◽

Oxygen Metabolism ◽

Health Condition ◽

Tissue Inhibitor Of Metalloproteinases ◽

Test Results ◽

Tissue Inhibitor ◽

System Functioning ◽

Important Correlation

Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well as all the processes taking part in maintenance of efficient homeostasis. Presentation of the correlation between exercise test results and MMP-8 (metalloproteinase-8) and TIMP-1 (tissue inhibitor of metalloproteinases-1) levels was attempted in this work. MMP-8 is a proteolytic enzyme taking part in progression of diseases related to process of ageing. 62 healthy women in postmenopausal period were qualified for the study (mean age:54±3.6). There was exercise test on the treadmill according to Bruce’s protocol performed. MMP-8 and TIMP-1 serum levels were measured. There was statistically important correlation between increased level of MMP-8 and increased level of TIMP-1 with lower results of exercise test observed. The conducted study provides further biochemical arguments for prophylactic role of physical activity, which lowers the risk of noninfectious diseases, typical for middle adulthood, by influencing physical capacity.

Download Full-text