Total and endogenous lipid oxidation in obese women during a 10 weeks weight loss program based on a moderately high protein energy-restricted diet

2004 ◽  
Vol 24 (1) ◽  
pp. 7-18 ◽  
Author(s):  
Idoia Labayen ◽  
Nieves Díez ◽  
Dolores Parra ◽  
Alvaro González ◽  
J.Alfredo Martínez
2013 ◽  
Vol 29 (9) ◽  
pp. 839-842 ◽  
Author(s):  
Kamilla Karlsen ◽  
Peter Humaidan ◽  
Lise H. Sørensen ◽  
Birgit Alsbjerg ◽  
Pernille Ravn

2002 ◽  
Vol 34 (5) ◽  
pp. S73
Author(s):  
L Marsh ◽  
A Zuckerman ◽  
A Faul ◽  
P Martin ◽  
M A. Welsch

2011 ◽  
Vol 106 (4) ◽  
pp. 486-490 ◽  
Author(s):  
J. R. Ruiz ◽  
E. Larrarte ◽  
J. Margareto ◽  
R. Ares ◽  
P. Alkorta ◽  
...  

The aim of the present study was to investigate the association of PLIN1 11482G>A (rs894160) and PLIN1 13041A>G (rs2304795) polymorphisms with body composition, energy and substrate metabolism, and the metabolic response to a 12-week energy-restricted diet in obese women. The study comprised a total of seventy-eight obese (BMI 34·0 (sd 2·8) kg/m2) women (age 36·7 (sd 7) years). We measured weight, height and waist circumference before and after a 12-week controlled energy-restricted diet intervention. Body fat mass and lean mass were measured by dual-energy X-ray absorptiometry. RMR and lipid oxidation rate were measured by indirect calorimetry. We also analysed fasting plasma glucose, insulin, cholesterol and leptin. Women carrying the 11482A allele had a lower reduction in waist circumference than non-A allele carriers (3·2 (sd 0·5) v. 4·6 (sd 0·6) %, respectively, P = 0·047; P for gene–diet interaction = 0·064). Moreover, women with the 11482A allele had a higher decrease in lipid oxidation rate than non-A allele carriers (58·9 (sd 6·7) v. 31·3 (sd 8·2) %, respectively, P = 0·012; P for gene–diet interaction = 0·004). There was no interaction effect between the 13041A>G polymorphism and diet-induced changes on the outcome variables (all P>0·1). These results confirm and extend previous findings suggesting that the PLIN1 11482G>A polymorphism plays a modulating role on diet-induced changes in body fat and energy metabolism in obese women.


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