Antihyperalgesic effects of cizolirtine in diabetic rats: behavioral and biochemical studies

Pain ◽  
2004 ◽  
Vol 110 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Bertrand Aubel ◽  
Valérie Kayser ◽  
Annie Mauborgne ◽  
Antonio Farré ◽  
Michel Hamon ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Biochemical Studies

Parkinsonia aculeata aqueous extract fraction: Biochemical studies in alloxan-induced diabetic rats

2007 ◽  
Vol 111 (3) ◽  
pp. 547-552 ◽  
Author(s):  
A.C.R. Leite ◽  
T.G. Araújo ◽  
B.M. Carvalho ◽  
N.H. Silva ◽  
V.L.M. Lima ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Diabetic Rats ◽  
Parkinsonia Aculeata ◽  
Biochemical Studies ◽  
Extract Fraction

scholarly journals Hypoglycemic Effect of Macrocyclic Binuclear Oxovanadium (IV) Complex on Streptozotocin-Induced Diabetic Rats

2004 ◽  
Vol 5 (2) ◽  
pp. 137-142 ◽  
Author(s):  
B. Ramachandran ◽  
D. Sathish Sekar ◽  
M. Kandaswamy ◽  
V. Narayanan ◽  
S. Subramanian
Keyword(s):  
Blood Glucose ◽  
Side Effects ◽  
Diabetic Rats ◽  
Spectral Studies ◽  
Vanadium Complexes ◽  
Vanadium Complex ◽  
Glucose Load ◽  
Oxovanadium Complex ◽  
Composition And Structure ◽  
Biochemical Studies

Though vanadium complexes mimic the action of insulin, owing to their toxicity, research is still in progress for a new vanadium complex with maximum efficacy at low concentration and without any side effects. A novel macrocyclic binuclear oxovanadium complex was synthesized, its composition and structure were confirmed by spectral studies and its efficacy was studied in streptozotocin-induced diabetic rats over a period of 30 days. The oral administration of the complex normalizes the blood glucose level in the diabetic rats and also maintains normoglycemia after a glucose load. The biochemical studies revealed that the complex is not toxic to the system. The nontoxic nature of this complex may be due to the presence of the vanadyl ions in an intact form. The study highlights the nontoxic and hypoglycemic effects of the new macrocyclic binuclear oxovanadium complex.

Biochemical Studies of Bone from Diabetic Rats and Rats Bearing Transplanted Pancreatic Islets

Pathobiology ◽  
1981 ◽  
Vol 49 (2) ◽  
pp. 61-67 ◽  
Author(s):  
Ruth Silberberg ◽  
David W. Scharp ◽  
Peggy A. Lesker
Keyword(s):  
Pancreatic Islets ◽  
Diabetic Rats ◽  
Biochemical Studies

Sites of Insulin Action Using Ferritin Labeling

1971 ◽  
Vol 29 ◽  
pp. 540-541
Author(s):  
Burton B. Silver ◽  
Ronald S. Nelson
Keyword(s):  
Electron Microscopy ◽  
Binding Sites ◽  
Anterior Pituitary ◽  
Insulin Action ◽  
Diabetic Rats ◽  
Insulin Antibody ◽  
Fat Pad ◽  
Target Organs ◽  
Uranium Salts ◽  
Sugar Levels

Some investigators feel that insulin does not enter cells but exerts its influence in some manner on the cell surface. Ferritin labeling of insulin and insulin antibody was used to determine if binding sites of insulin to specific target organs could be seen with electron microscopy.Alloxanized rats were considered diabetic if blood sugar levels were in excess of 300 mg %. Test reagents included ferritin, ferritin labeled insulin, and ferritin labeled insulin antibody. Target organs examined were were diaphragm, kidney, gastrocnemius, fat pad, liver and anterior pituitary. Reagents were administered through the left common carotid. Survival time was at least one hour in test animals. Tissue incubation studies were also done in normal as well as diabetic rats. Specimens were fixed in gluteraldehyde and osmium followed by staining with lead and uranium salts. Some tissues were not stained.

Ruthenium Red Staining of Human Hard Keratin Fibers

1982 ◽  
Vol 40 ◽  
pp. 278-279
Author(s):  
M. C. Buhrer ◽  
R. A. Mathews
Keyword(s):  
Human Hair ◽  
Ruthenium Red ◽  
Acid Mucopolysaccharides ◽  
Biochemical Studies ◽  
Keratin Fibers ◽  
Ruthenium Red Staining ◽  
Extracellular Materials

Ruthenium red has been used as a stain to demonstrate a variety of extracellular materials, especially acid mucopolysaccharides. It also reacts with certain intracellular and extracellular lipids. Since biochemical studies in our laboratory demonstrated the presence of a variety of monosaccharides in human hair ruthenium red staining procedures were adopted in order to evaluate the presence and morphological location of acid oligosaccharides in the keratinized aspect of hair.

Effects of Hypophysectomy on the Fine Structure of Rat Liver Cells

1967 ◽  
Vol 25 ◽  
pp. 156-157
Author(s):  
Robert R. Cardell
Keyword(s):  
Electron Microscopy ◽  
Fine Structure ◽  
Rat Liver ◽  
Liver Cell ◽  
Anterior Pituitary ◽  
Liver Cells ◽  
Biochemical Studies ◽  
Liver Functions ◽  
Rat Liver Cells ◽  
And Control

Hypophysectomy of the rat renders this animal deficient in the hormones of the anterior pituitary gland, thus causing many primary and secondary hormonal effects on basic liver functions. Biochemical studies of these alterations in the rat liver cell are quite extensive; however, relatively few morphological observations on such cells have been recorded. Because the available biochemical information was derived mostly from disrupted and fractionated liver cells, it seemed desirable to examine the problem with the techniques of electron microscopy in order to see what changes are apparent in the intact liver cell after hypophysectomy. Accordingly, liver cells from rats which had been hypophysectomized 5-120 days before sacrifice were studied. Sham-operated rats served as controls and both hypophysectomized and control rats were fasted 15 hours before sacrifice.

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