Protective effect of caffeic acid phenethyl ester against imidacloprid-induced hepatotoxicity by attenuating oxidative stress, endoplasmic reticulum stress, inflammation and apoptosis

2020 ◽  
Vol 164 ◽  
pp. 122-129
Author(s):  
Bo Shao ◽  
Meixia Wang ◽  
Anran Chen ◽  
Chunzhi Zhang ◽  
Li Lin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

Testicular Injury Attenuated by Rapamycin Through Induction of Autophagy and Inhibition of Endoplasmic Reticulum Stress in Streptozotocin- Induced Diabetic Rats

2019 ◽  
Vol 19 (5) ◽  
pp. 665-675 ◽  
Author(s):  
Wenjiao Shi ◽  
Zhixin Guo ◽  
Ruixia Yuan
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
Er Stress ◽  
B Cell Lymphoma ◽  
Diabetic Rats ◽  
Pathological Changes ◽  
Rapamycin Treatment ◽  
Related Proteins

Background and Objective: This study investigated whether rapamycin has a protective effect on the testis of diabetic rats by regulating autophagy, endoplasmic reticulum stress, and oxidative stress. Methods: Thirty male Sprague-Dawley rats were randomly divided into three groups: control, diabetic, and diabetic treated with rapamycin, which received gavage of rapamycin (2mg.kg-1.d-1) after induction of diabetes. Diabetic rats were induced by intraperitoneal injection of streptozotocin (STZ, 65mg.Kg-1). All rats were sacrificed at the termination after 8 weeks of rapamycin treatment. The testicular pathological changes were determined by hematoxylin and eosin staining. The protein or mRNA expression of autophagy-related proteins (Beclin1, microtubule-associated protein light chain 3 (LC3), p62), ER stress marked proteins (CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), caspase-12), oxidative stress-related proteins (p22phox, nuclear factor erythroid2-related factor 2 (Nrf2)) and apoptosis-related proteins (Bax, B cell lymphoma-2 (Bcl-2)) were assayed by western blot or real-time fluorescence quantitative PCR. Results: There were significant pathological changes in the testes of diabetic rats. The expression of Beclin1, LC3, Nrf2, Bcl-2 were significantly decreased and p62, CHOP, caspase12, p22phox, and Bax were notably increased in the testis of diabetic rats (P <0.05). However, rapamycin treatment for 8 weeks significantly reversed the above changes in the testis of diabetic rats (P <0.05). Conclusion: Rapamycin appears to produce a protective effect on the testes of diabetic rats by inducing the expression of autophagy and inhibiting the expression of ER-stress, oxidative stress, and apoptosis.

Protective effect of Caffeic Acid Phenethyl Ester (CAPE) against oxidative stress

2017 ◽  
Vol 29 ◽  
pp. 178-184 ◽  
Author(s):  
Ana Laura Carreño ◽  
Efrain Alday ◽  
Jael Quintero ◽  
Lucía Pérez ◽  
Dora Valencia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

scholarly journals Protective Effect of Caffeic Acid Phenethyl Ester on Antituberculosis Drug-Induced Hepatotoxicity in Rats

2018 ◽  
Vol 102 (9-10) ◽  
pp. 473-478 ◽  
Author(s):  
Cigdem Aliosmanoglu ◽  
Halil Erbiş ◽  
Ibrahim Aliosmanoglu ◽  
Mehmet Akif Türkoglu ◽  
Burak Veli Ulger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Liver Function Tests ◽  
Caffeic Acid Phenethyl Ester ◽  
Stress Index ◽  
Albino Rats ◽  
Drug Induced ◽  
Antituberculosis Treatment

Isoniazid and rifampicin are drugs primarily used in antituberculosis treatment. Our aim in this study is to evaluate the effect of caffeic acid phenethyl ester's protective effect on liver function tests and to trace elements in hepatic damage caused by isoniazid and rifampicin on rats. Forty Wistar albino rats were divided into 4 groups. Group 1: Sham, Group 2: caffeic acid phenethyl ester application, Group 3: isoniazid and rifampicin given, Group 4: isoniazid + rifampicin and caffeic acid phenethyl ester application. After 30 days, the rats were sacrificed by taking blood from the heart. Alanine aminotransferase, aspartate aminotransferase, zinc, copper, total antioxidant capacity, total oxidative status, and oxidative stress index levels were evaluated. The rats to which isoniazid + rifampicin+ caffeic acid phenethyl ester were given had less oxidative stress and copper levels (P &lt; 0.001, P = 0.019) but have higher zinc levels (P = 0.001) compared to the isoniazid + rifampicin group. Liver enzyme levels were also lower in rats that were given isoniazid + rifampicin + caffeic acid phenethyl ester (P &lt; 0.001). The results of this study suggested that caffeic acid phenethyl ester influences the levels of trace elements (copper and zinc) that are important for the physiologic mechanisms of organisms, reducing liver damage.

Protective Effect of Caffeic Acid Phenethyl Ester on Oxidative Stress in Diabetic Rat Sciatic Nerve

2012 ◽  
Vol 8 (6) ◽  
pp. 577-581 ◽  
Author(s):  
Yavuz Yucel ◽  
Tahsin Celepkolu ◽  
Erkan Kibrisli ◽  
Faruk Kilinc ◽  
Coskun Beyaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sciatic Nerve ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Diabetic Rat ◽  
Rat Sciatic Nerve
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