Exploring the “other” subfamily of HECT E3-ligases for therapeutic intervention

2021 ◽  
pp. 107809
Author(s):  
Sunil Singh ◽  
Joel Ng ◽  
J. Sivaraman
Author(s):  
Manish Munjal ◽  
Archana Arora ◽  
Amanjot Kaur ◽  
Gopika Talwar ◽  
Rupinder Mirley ◽  
...  

A retropharyngeal abscess is a suppurative collection of the deep spaces of the neck. Mostly at presentation they are massive and are a dilemma for the surgeon and the anesthetist alike, vying for space, one for therapeutic intervention and the other for airway access. Video laryngoscopic assisted evacuation of such a collection, adopting the nasopharyngeal and the transoral route was undertaken in a middle aged individual which is being reported.


2020 ◽  
Vol 21 (15) ◽  
pp. 5369
Author(s):  
Anna Lopata ◽  
Andreas Kniss ◽  
Frank Löhr ◽  
Vladimir V. Rogov ◽  
Volker Dötsch

In this review, we focus on the ubiquitination process within the endoplasmic reticulum associated protein degradation (ERAD) pathway. Approximately one third of all synthesized proteins in a cell are channeled into the endoplasmic reticulum (ER) lumen or are incorporated into the ER membrane. Since all newly synthesized proteins enter the ER in an unfolded manner, folding must occur within the ER lumen or co-translationally, rendering misfolding events a serious threat. To prevent the accumulation of misfolded protein in the ER, proteins that fail the quality control undergo retrotranslocation into the cytosol where they proceed with ubiquitination and degradation. The wide variety of misfolded targets requires on the one hand a promiscuity of the ubiquitination process and on the other hand a fast and highly processive mechanism. We present the various ERAD components involved in the ubiquitination process including the different E2 conjugating enzymes, E3 ligases, and E4 factors. The resulting K48-linked and K11-linked ubiquitin chains do not only represent a signal for degradation by the proteasome but are also recognized by the AAA+ ATPase Cdc48 and get in the process of retrotranslocation modified by enzymes bound to Cdc48. Lastly we discuss the conformations adopted in particular by K48-linked ubiquitin chains and their importance for degradation.


2013 ◽  
Vol 14 (6) ◽  
pp. 1189-1192
Author(s):  
Anila Karunakaran ◽  
Rathy Ravindran ◽  
Mahesh Shenoy ◽  
Mohammed Arshad ◽  
MK Shruthi Laxmi

ABSTRACT Primary mucosal malignant melanoma is of unusual occurrence and poor prognosis. We report two cases of primary mucosal melanoma, one in a 70-year-old male in the palate and the other in a 73-year-old female in the maxillary sinus. Early diagnosis and proper clinical and cytologic evaluation is necessary to institute therapeutic intervention. These cases are reported on account of their rarity of occurrence and difficulty of treatment. How to cite this article Karunakaran A, Ravindran R, Shenoy M, Arshad M, Laxmi MKS. Primary Mucosal Melanoma: Report of Two Cases. J Contemp Dent Pract 2013;14(6):1189-1192.


1985 ◽  
Vol 7 (1) ◽  
Author(s):  
Helmut Thomä ◽  
Horst Kächele ◽  
Julian Ch. Kübler

AbstractAccording to psychoanalysis there is a relationship between gaining insight and therapeutic success. To clarify this relationship it is necessary to differentiate regions of psychoanalytic theory. On the one hand there are foundational theories - personality and aetiological theory - on the other hand there are technological theories: they explain the therapeutic process and generate rules for therapeutic intervention. The latter are supported by the former, but cannot be logically derived from them. The link between the mediation of self-knowledge and the improvement of the state of the patient is a theoretical and practical issue of psychoanalysis: theoretically it is a hypothesis that has to be proved by empirical investigation. Practically it is an aim to be fulfilled. A therapeutic theory should list the conditions that are necessary for this.


1988 ◽  
Vol 62 (03) ◽  
pp. 411-419 ◽  
Author(s):  
Colin W. Stearn

Stromatoporoids are the principal framebuilding organisms in the patch reef that is part of the reservoir of the Normandville field. The reef is 10 m thick and 1.5 km2in area and demonstrates that stromatoporoids retained their ability to build reefal edifices into Famennian time despite the biotic crisis at the close of Frasnian time. The fauna is dominated by labechiids but includes three non-labechiid species. The most abundant species isStylostroma sinense(Dong) butLabechia palliseriStearn is also common. Both these species are highly variable and are described in terms of multiple phases that occur in a single skeleton. The other species described areClathrostromacf.C. jukkenseYavorsky,Gerronostromasp. (a columnar species), andStromatoporasp. The fauna belongs in Famennian/Strunian assemblage 2 as defined by Stearn et al. (1988).


1967 ◽  
Vol 28 ◽  
pp. 207-244
Author(s):  
R. P. Kraft

(Ed. note:Encouraged by the success of the more informal approach in Christy's presentation, we tried an even more extreme experiment in this session, I-D. In essence, Kraft held the floor continuously all morning, and for the hour and a half afternoon session, serving as a combined Summary-Introductory speaker and a marathon-moderator of a running discussion on the line spectrum of cepheids. There was almost continuous interruption of his presentation; and most points raised from the floor were followed through in detail, no matter how digressive to the main presentation. This approach turned out to be much too extreme. It is wearing on the speaker, and the other members of the symposium feel more like an audience and less like participants in a dissective discussion. Because Kraft presented a compendious collection of empirical information, and, based on it, an exceedingly novel series of suggestions on the cepheid problem, these defects were probably aggravated by the first and alleviated by the second. I am much indebted to Kraft for working with me on a preliminary editing, to try to delete the side-excursions and to retain coherence about the main points. As usual, however, all responsibility for defects in final editing is wholly my own.)


1967 ◽  
Vol 28 ◽  
pp. 177-206
Author(s):  
J. B. Oke ◽  
C. A. Whitney

Pecker:The topic to be considered today is the continuous spectrum of certain stars, whose variability we attribute to a pulsation of some part of their structure. Obviously, this continuous spectrum provides a test of the pulsation theory to the extent that the continuum is completely and accurately observed and that we can analyse it to infer the structure of the star producing it. The continuum is one of the two possible spectral observations; the other is the line spectrum. It is obvious that from studies of the continuum alone, we obtain no direct information on the velocity fields in the star. We obtain information only on the thermodynamic structure of the photospheric layers of these stars–the photospheric layers being defined as those from which the observed continuum directly arises. So the problems arising in a study of the continuum are of two general kinds: completeness of observation, and adequacy of diagnostic interpretation. I will make a few comments on these, then turn the meeting over to Oke and Whitney.


1966 ◽  
Vol 24 ◽  
pp. 337
Author(s):  
W. Iwanowska

A new 24-inch/36-inch//3 Schmidt telescope, made by C. Zeiss, Jena, has been installed since 30 August 1962, at the N. Copernicus University Observatory in Toruń. It is equipped with two objective prisms, used separately, one of crown the other of flint glass, each of 5° refracting angle, giving dispersions of 560Å/mm and 250Å/ mm respectively.


2020 ◽  
Vol 43 ◽  
Author(s):  
Philip Pettit

Abstract Michael Tomasello explains the human sense of obligation by the role it plays in negotiating practices of acting jointly and the commitments they underwrite. He draws in his work on two models of joint action, one from Michael Bratman, the other from Margaret Gilbert. But Bratman's makes the explanation too difficult to succeed, and Gilbert's makes it too easy.


1999 ◽  
Vol 173 ◽  
pp. 249-254
Author(s):  
A.M. Silva ◽  
R.D. Miró

AbstractWe have developed a model for theH2OandOHevolution in a comet outburst, assuming that together with the gas, a distribution of icy grains is ejected. With an initial mass of icy grains of 108kg released, theH2OandOHproductions are increased up to a factor two, and the growth curves change drastically in the first two days. The model is applied to eruptions detected in theOHradio monitorings and fits well with the slow variations in the flux. On the other hand, several events of short duration appear, consisting of a sudden rise ofOHflux, followed by a sudden decay on the second day. These apparent short bursts are frequently found as precursors of a more durable eruption. We suggest that both of them are part of a unique eruption, and that the sudden decay is due to collisions that de-excite theOHmaser, when it reaches the Cometopause region located at 1.35 × 105kmfrom the nucleus.


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