The ketogenic diet affects the social behavior of young male rats

The purpose of this study was to evaluate the effects of age and sex on trait ascriptions toward male targets. Young (n = 40) and elderly (n = 40) participants rated young and elderly male targets on a number of traits of social desirability and resourcefulness using the Social Desirability Index (Perlini, Bertolissi, & Lind, 1999). Consistent with previous research on female targets, male targets were considered more socially desirable when they were young; moreover, the social desirability of the target male was considered more favorable when undertaken by an elderly evaluator. Elderly participants rated the young male target as more resourceful than the elderly male target, and more resourceful than the young participants rated the young male target. Results are discussed in terms of evolutionary and role theories of social behavior.

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The social behavior of male rats administered an adult-onset calorie restriction regimen

Physiology & Behavior ◽

10.1016/j.physbeh.2008.12.012 ◽

2009 ◽

Vol 96 (4-5) ◽

pp. 581-585 ◽

Cited By ~ 7

Author(s):

Antonina Govic ◽

Elizabeth A. Levay ◽

Stephen Kent ◽

Antonio G. Paolini

Keyword(s):

Social Behavior ◽

Calorie Restriction ◽

Male Rats ◽

Adult Onset ◽

The Social

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The modification of the ketogenic diet mitigates its stunting effects in rodents

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2017-0374 ◽

2018 ◽

Vol 43 (2) ◽

pp. 203-210 ◽

Cited By ~ 1

Author(s):

Arkadiusz Damian Liśkiewicz ◽

Daniela Kasprowska-Liśkiewicz ◽

Anna Sługocka ◽

Marta Maria Nowacka-Chmielewska ◽

Jan Wiaderkiewicz ◽

...

Keyword(s):

Side Effects ◽

Ketogenic Diet ◽

Wheat Bran ◽

Neurological Disorders ◽

Functional Performance ◽

Young Male ◽

Male Rats ◽

Low Carbohydrate ◽

Daily Body Weight

The high-fat and low-carbohydrate ketogenic diet (HFKD) is extensively studied within the fields of numerous diseases, including cancer and neurological disorders. Since most studies incorporate animal models, ensuring the quality of ketogenic rodent diets is important, both in the context of laboratory animal welfare as well as for the accuracy of the obtained results. In this study we implemented a modification to a commonly used ketogenic rodent chow by replacing non-resorbable cellulose with wheat bran. We assessed the effects of month-long treatment with either the unmodified or the modified HFKD on the growth and development of young male rats. Daily body weight, functional performance, and brain morphometric parameters were assessed to evaluate the influence of both applied diets on rodent development. Our results revealed that the unmodified ketogenic chow induced strong side effects that included weakness, emaciation, and brain undergrowth concomitant to growth inhibition. However, application of the ketogenic chow supplemented with wheat bran suppressed these adverse side effects, which was associated with the restoration of insulin-like growth factor 1 and a decrease in corticosterone levels. We have also shown that the advantageous results of the modified HFKD are not species- or sex-specific. Our data indicate that the proposed HFKD modification even allows for its application in young animals, without causing detrimental side effects.

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The Role of Oxytocin, Vasopressin, and D-Cycloserine in Remediating Social Behavior in Rats with Amygdala Lesions

Journal of Student Research ◽

10.47611/jsr.v1i1.60 ◽

2012 ◽

Vol 1 (1) ◽

pp. 53-59

Author(s):

Kristina Lauren Scanlan ◽

Alan Gittis ◽

Robin McGovern

Keyword(s):

Social Behavior ◽

Neurodevelopmental Disorder ◽

Autism Spectrum ◽

Social Impairment ◽

Female Rats ◽

Male Rats ◽

Sexually Dimorphic ◽

Social Deficits ◽

The Social ◽

Amygdala Lesions

Autism is a common neurodevelopmental disorder that affects communication and social behavior. To reduce the social deficits characteristic of autism, the compounds oxytocin, arginine vasopressin, D-cycloserine, and D-cycloserine + oxytocin were explored as therapeutic agents. Twenty-one Long Evans Hooded rats underwent a bilateral amygdala lesion, which reduced the time of social interactions between the pairs of animals. Upon administration of D-cycloserine, the social deficits induced by the lesions were significantly reversed in both sexes. In addition, it was observed that the efficacy of the treatments was affected by the sex of the subjects. Male rats had the largest increase in social behavior when given D-cycloserine. However, female rats experienced the largest reduction in social impairment when administered oxytocin. Thus, sexually dimorphic treatments should be further investigated for individuals with autism spectrum disorders.

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