scholarly journals The modification of the ketogenic diet mitigates its stunting effects in rodents

2018 ◽  
Vol 43 (2) ◽  
pp. 203-210 ◽  
Author(s):  
Arkadiusz Damian Liśkiewicz ◽  
Daniela Kasprowska-Liśkiewicz ◽  
Anna Sługocka ◽  
Marta Maria Nowacka-Chmielewska ◽  
Jan Wiaderkiewicz ◽  
...  
Keyword(s):  
Side Effects ◽  
Ketogenic Diet ◽  
Wheat Bran ◽  
Neurological Disorders ◽  
Functional Performance ◽  
Young Male ◽  
Male Rats ◽  
Low Carbohydrate ◽  
Daily Body Weight

The high-fat and low-carbohydrate ketogenic diet (HFKD) is extensively studied within the fields of numerous diseases, including cancer and neurological disorders. Since most studies incorporate animal models, ensuring the quality of ketogenic rodent diets is important, both in the context of laboratory animal welfare as well as for the accuracy of the obtained results. In this study we implemented a modification to a commonly used ketogenic rodent chow by replacing non-resorbable cellulose with wheat bran. We assessed the effects of month-long treatment with either the unmodified or the modified HFKD on the growth and development of young male rats. Daily body weight, functional performance, and brain morphometric parameters were assessed to evaluate the influence of both applied diets on rodent development. Our results revealed that the unmodified ketogenic chow induced strong side effects that included weakness, emaciation, and brain undergrowth concomitant to growth inhibition. However, application of the ketogenic chow supplemented with wheat bran suppressed these adverse side effects, which was associated with the restoration of insulin-like growth factor 1 and a decrease in corticosterone levels. We have also shown that the advantageous results of the modified HFKD are not species- or sex-specific. Our data indicate that the proposed HFKD modification even allows for its application in young animals, without causing detrimental side effects.

Effects of a low-carbohydrate ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain: A pilot randomised clinical trial

Pain Medicine ◽  
2021 ◽  
Author(s):  
Rowena Field ◽  
Fereshteh Pourkazemi ◽  
Kieron Rooney
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Ketogenic Diet ◽  
Pain Reduction ◽  
Management Tool ◽  
Processed Foods ◽  
Blood Biomarkers ◽  
Low Carbohydrate ◽  
Average Pain

Abstract Background A low-carbohydrate ketogenic diet has been reported to improve chronic pain by reducing inflammation, oxidative stress, and sensitivity within the nervous system. The main aim of this trial is to evaluate the effects of a ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain. Methods Participants with chronic musculoskeletal pain were recruited for a 12-week diet intervention that commenced with a 3-week run-in diet removing ultra-processed foods, followed by randomisation to either a whole-food/well-formulated ketogenic diet (WFKD) or to continue with the minimally processed whole-food diet (WFD). Outcome measures included: average pain (visual analogue scale VAS), blood biomarkers, anthropometrics, adherence, depression, anxiety, sleep, ketones, quality of life, diet satisfaction and macronutrient intake. Results Average weekly pain improved for both groups. WFKD group VAS reduced by 17.9 ± 5.2 mm (p = 0.004) and the WFD group VAS reduced 11.0 ± 9.0 mm (p = 0.006). Both groups also reported improved quality of life (WFKD = 11.5 ± 2.8%, p = 0.001 and WFD = 11.0 ± 3.5%, p = 0.014). The WFKD group also demonstrated significant improvements in pain interference (p = 0.013), weight (p < 0.005), depression (p = 0.015), anxiety (p = 0.013), and inflammation (hsCRP) (p = 0.009). Significant average pain reduction remained at three-month follow-up for both groups (WFKD p = 0.031, WFD p = 0.011). Conclusion The implementation of a whole-food diet that restricts ultra-processed foods is a valid pain management tool, however a low-carbohydrate ketogenic diets may have potentially greater pain reduction, weight loss and mood improvements.

scholarly journals Use of Complementary and Alternative Medical Therapies in a Pediatric Neurology Clinic

2005 ◽  
Vol 32 (4) ◽  
pp. 524-528 ◽  
Author(s):  
Isaac Soo ◽  
Jean K. Mah ◽  
Karen Barlow ◽  
Lorie Hamiwka ◽  
Elaine Wirrell
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Neurological Disorders ◽  
Herbal Remedies ◽  
Dietary Therapy ◽  
Pediatric Neurology ◽  
Significant Difference ◽  
Neurology Clinic ◽  
Complementary And Alternative

ABSTRACT:Background:Complementary and alternative medicine (CAM) is increasingly used in adults and children. Studies on CAM in neurological disorders have focused on the adult population and its use among pediatric neurology patients has not been well characterized.Objectives:The purpose of this study was: 1) To characterize the prevalence of CAM in pediatric neurology patients; 2) To determine the perceived effectiveness of CAM in these children; 3) To compare the cost of CAM with conventional therapies; and 4) To describe caregiver or patient-related variables associated with the use of CAM.Methods:This was a cross-sectional survey of patients and families attending the Alberta Children's Hospital neurology clinic between February and May 2004. Patients were considered eligible if they were between two and 18 years of age and had a known history of neurological disorders. Caregivers completed several self-administered questionnaires regarding their socio-demographic profile, their child's neurological illness, and their experience with CAM. Caregivers also rated their child's quality of life using the Pediatric Quality of Life Inventory.Results:One hundred and five of 228 (46%) families completed the survey. The mean age of the neurology patients was 9.8 ± 4.5 years. Forty-six (44%) out of 105 patients received one or more types of CAM, with the most common types being chiropractic manipulations (15%), dietary therapy (12%), herbal remedies (8%), homeopathy (8%), and prayer/faith healing (8%). Caregivers' sociodemographic variables or pediatric health-related quality of life were not significantly associated with the use of CAM. Fifty-nine percent of CAM users reported benefits, and only one patient experienced side effects. There was no significant difference in the total median cost of CAM compared to conventional therapies ($31.70 vs. $50.00 per month). Caregivers' personal experience or success stories from friends and media were common reasons for trying CAM.Conclusions:The use of CAM was common among pediatric neurology patients. Over half of the families reported benefits with CAM, and side effects were perceived to be few. Physicians should initiate discussion on CAM during clinic visits so that the families and patients can make informed decisions about using CAM. Further studies should address the specific role of CAM in children with neurological disorders, and to determine the potential interactions between CAM and conventional therapies in these patients.

scholarly journals Effect of Ketogenic Diet on Quality of Life in Adults with Chronic Disease: A Systematic Review of Randomized Controlled Trials

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4463
Author(s):  
Myriam Abboud ◽  
Fatme AlAnouti ◽  
Evridiki Georgaki ◽  
Dimitrios Papandreou
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Chronic Disease ◽  
Side Effects ◽  
Adverse Events ◽  
Randomized Controlled Trials ◽  
Ketogenic Diet ◽  
Controlled Trials ◽  
Randomized Controlled

Background: Chronic diseases adversely affect quality of life (QOL). The ketogenic diet (KD) may improve the QOL. Objective: The aim of this systematic review was to summarize the available evidence of randomized controlled trials (RCTs) to establish the effect of KD on the QOL in adults with chronic diseases. Methods: Reporting followed PRISMA guidelines. We included randomized controlled trials (RCTs) conducted on adults with chronic disease including an intervention group that received KD and a control group, and where QOL was reported as outcome. We searched PubMed, APA PsycInfo, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Library, and Clinicaltrials.gov, and the references of the included articles and previous relevant reviews, without language or time restrictions. We critically appraised included studies and narratively synthesized their findings. Results: Nine RCTs were included. The risk of bias was low, except of allocation concealment and blinding. In patients with cancer: one RCT found an improvement in overall QOL, another reported improved physical component summary, and one found no superiority of KD in all QOL domains. In patients with neurological disorders: improved QOL was reported in Alzheimer’s disease patients, whereas no difference in mental and physical health QOL was noted in patients with multiple sclerosis. In patients with obesity and type II diabetes: one RCT reported superiority of energy-restricted KD in improving role functioning, mental health, health perceptions, and pain compared with guideline-based diet, whereas in another RCT, high and low carbohydrate diets achieved comparable improvements. Among patients with knee osteoarthritis, no differences between KD and low-fat groups were noted. Dietary compliance with the KD, reported in three studies, was shown to be high. Side effects were mostly noted during the first weeks of intervention, and adverse events were not markedly different with KD and the comparison diet. Conclusions: The evidence from RCTs investigating the effect of KD on QOL in adults with chronic disease is inconclusive. The promising effect noted in some included studies and the low rates of adverse events and side effects encourage future investigations in this regard.

Anti-Inflammatory Effects of a Ketogenic Diet

2016 ◽  
Author(s):  
Nina Dupuis ◽  
Stéphane Auvin
Keyword(s):  
Multiple Sclerosis ◽  
Ketogenic Diet ◽  
Neurological Disorders ◽  
Ketone Bodies ◽  
Experimental Models ◽  
High Fat ◽  
Pharmacoresistant Epilepsy ◽  
Epileptic Encephalopathies ◽  
Low Carbohydrate ◽  
Anti Inflammatory

The high-fat, low-carbohydrate ketogenic diet (KD) is an established and proven treatment for pharmacoresistant epilepsy. Recently, the KD is being explored for some inflammation-induced epileptic encephalopathies. Given the broad neuroprotective properties of the KD in various experimental models of neurological disorders, there are yet additional potential future uses. Consistent with this, there is growing evidence that the KD exerts anti-inflammatory activity. Ketone bodies, caloric restriction, and polyunsaturated fatty acids might be involved in the modulation of inflammation by the KD. This chapter reviews the evidence that, in part through anti-inflammatory effects, the KD holds promise in the treatment of certain epileptic disorders, neuropathic pain, multiple sclerosis, and Parkinson’s disease.

The ketogenic diet affects the social behavior of young male rats

2017 ◽  
Vol 179 ◽  
pp. 168-177 ◽  
Author(s):  
Daniela Kasprowska-Liśkiewicz ◽  
Arkadiusz D. Liśkiewicz ◽  
Marta M. Nowacka-Chmielewska ◽  
Joanna Nowicka ◽  
Andrzej Małecki ◽  
...  
Keyword(s):  
Social Behavior ◽  
Ketogenic Diet ◽  
Young Male ◽  
Male Rats ◽  
The Social

scholarly journals Ketogenic Diet

2013 ◽  
Vol 40 (2) ◽  
pp. 158-167 ◽  
Author(s):  
Radhika Dhamija ◽  
Susan Eckert ◽  
Elaine Wirrell
Keyword(s):  
Side Effects ◽  
Ketogenic Diet ◽  
Neurological Disorders ◽  
Practical Approach ◽  
Different Types ◽  
Patients With Epilepsy

About one third of patients with epilepsy are pharmacoresistent. For a subgroup of this population, the ketogenic diet can be highly efficacious and should be considered early. This review discusses the different types of ketogenic diet, proposed mechanism of actions and its evidence for use in children and adults with both generalized and focal epilepsies where surgery is not feasible. In addition we discuss a practical approach to diet initiation, maintenance and monitoring for side effects. We also summarize the emerging evidence for the use of ketogenic diet in a broad range of neurological disorders.

Effects of Threonine Supplementation on the Slope Assay for Protein Quality

1977 ◽  
Vol 60 (6) ◽  
pp. 1291-1295
Author(s):  
John M McLaughlan ◽  
Murray O Keith
Keyword(s):  
Protein Efficiency Ratio ◽  
Protein Quality ◽  
Young Male ◽  
Male Rats ◽  
Reference Standard ◽  
Efficiency Ratio ◽  
Protein Sources ◽  
Protein Levels ◽  
Low Protein

Abstract Several diets considered to be marginally deficient in threonine were fed to young male rats at protein levels ranging from 3 to 9%. Protein sources included lactalbumin (reference standard), soy protein with added methionine, pea protein with added methionine, rice-casein, and peanut-sesame-fish. Chemical scores and plasma amino acid scores indicated that these diets were limiting in threonine at the 3–4% protein level; increased growth resulted from supplementation with threonine. After threonine supplementation, all protein sources except pea were limiting in lysine. Increased growth at low protein levels with little or no extra growth at high protein levels due to threonine supplementation resulted in decreased slopes in the relative protein value (RPV) assay. Consequently, threonine supplementation apparently decreased RPV values for these samples but the protein efficiency ratio was not affected. It was concluded that the RPV assay underestimates the protein quality of lysine-deficient proteins.

scholarly journals Sperm Quality Reduction of Rats (Rattus novergivus) Injected by High Dosage of White Vitamin C in Long Term

2019 ◽  
Vol 6 (1) ◽  
pp. 7
Author(s):  
Ni Wayan Sudatri ◽  
Dwi Ariani Yulihastuti ◽  
Ni Made Suartini
Keyword(s):  
Side Effects ◽  
Vitamin C ◽  
Sperm Quality ◽  
Male Rats ◽  
High Dose ◽  
Treatment Groups ◽  
Randomized Design ◽  
High Doses

Benefits of white vitamin C to increace the immune system is already exis. However, the use of high doses of vitamin C and in the long term can cause side effects.. The objective of this study was to determine the side effects of high-dose injections of vitamin C in the long term on sperm quality of rats. The design used in this study is completely randomized design (CRD) with long treatment injections of high doses of vitamin C are different. ie: P0 (control), P1 (injected 30 days), P2 (injected 50 days ), P3 (injected 70 days) and P4 (injected 90 days). Parameters measured were sperm quality (motility, viability, morphology, number) ,. The results showed that the sperm quality of rats (Rattus novergivus). Sperm quality of male rats (Rattus norvegivus L.) were injected vitamin C in high doses for long periods of time between the control and treatment groups showed significant differences (P = 0.000). The quality of sperm of mice injected high doses of white vitamin C tend to decrease sperm  quality indicated by percentage of motility, viability, and morphology of spermatozoa although the concentration of spermatozoa  tends to increase. Keywords: white vitamin C, rat, sperm quality

scholarly journals A narrative review on the effects of a ketogenic diet on patients with Alzheimer's disease

2021 ◽  
Vol 9 (1) ◽  
pp. 185-193
Author(s):  
Ethan Ali Tabaie ◽  
◽  
Akshay Jakkidi Reddy ◽  
Hetal Brahmbhatt ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Ketogenic Diet ◽  
Cognitive Abilities ◽  
Future Research ◽  
Low Carbohydrate ◽  
Moderate Cognitive Impairment

<abstract> <p>Alzheimer's disease (AD) has been very difficult to prevent and cure using the medicine available today. However, there has been some hope with using a ketogenic diet (KD) to reduce the cognitive and quality of life decline experienced by patients with AD. In this review, the authors discuss the research done on the effect of a KD on AD to provide some potential avenues for future research and to determine a KD that can be best adopted by patients. The authors also go over the effects of KD's and low-carbohydrate diets (LCDs) on the cognitive function of healthy patients and on patients without AD to determine the similar and dissimilar effects of the diets. The authors found that the KD was able to improve the cognitive abilities and quality of life of patients ranging from mild to severe AD. Several types of memory were improved as a result of the diets. Further research needs to be conducted to determine the cause behind these improvements. However, the several studies that were done were mostly in agreement that once ketosis was reached, cognitive improvements were observed in patients ranging from mild to severe AD or mild to moderate cognitive impairment. Through the use of a KD, potential mechanisms can be found to reduce the cognitive decline of patients with AD, and potentially even prevent the damaging effects of cognitive decline from AD altogether.</p> </abstract>

Sign in / Sign up

Export Citation Format

Share Document