scholarly journals In vitro dissolution behaviour and absorption in humans of a novel mixed l-lysine salt formulation of EPA and DHA

2021 ◽  
Vol 164 ◽  
pp. 102232
Author(s):  
Koen Manusama ◽  
Michiel Balvers ◽  
Marlies Diepeveen-de Bruin ◽  
Laura Headley ◽  
Roberta Bosi ◽  
...  
Keyword(s):  
In Vitro Dissolution ◽  
Epa And Dha ◽  
Dissolution Behaviour ◽  
Salt Formulation

PERILAKU DISOLUSI KETOPROFEN DAN INDOMETASIN FARNESIL TERSALUT GEL KITOSAN-GOM GUAR

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Purwantiningsih Sugita ◽  
Bambang Srijanto ◽  
Budi Arifin ◽  
Fithri Amelia ◽  
Mahdi Mubarok
Keyword(s):  
Room Temperature ◽  
Guar Gum ◽  
Tween 80 ◽  
Chitosan Solution ◽  
In Vitro Dissolution ◽  
Dissolution Profile ◽  
Magnetic Stirrer ◽  
Dissolution Behaviour ◽  
Shrimp Shell Waste

Chitosan, a modification of shrimp-shell waste, has been utilized as microcapsule. However, it’s fragile gel property needs to be strengthened by adding glutaraldehyde (glu) and natural hydrocolloid guar gum (gg). This research’s purposes were to study dissolution behaviour of ketoprofen and infar through optimum chitosan-guar gum microcapsule. Into 228.6 mL of 1.75% (w/v) chitosan solution in 1% (v/v) acetic acid,38.1 mL of gg solution was added with concentration variation of 0.35, 0.55, and 0.75% (w/v) for ketoprofen microcapsules and 0.05, 0.19, and 0.33% (w/v) for infar microcapsules, and stirred with magnetic stirrer until homogenous. Afterwards, 7.62mL of glu was added slowly under stirring, with concentrations varied: 3, 3.5, and 4% (v/v) for ketoprofen microcapsules, and 4, 4.5, and 5% (v/v) for infar microcapsules. All mixtures were shaked for 20 minutes for homogenization. All mixtures wereshaked for 20 minutes for homogenization. Into each  microcapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added, whereas solution of 100 mg of in 250 mL of 96% ethanol was added into each microcapsule mixture for infar. Every mixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Everymixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. The data of [gg], [glu], and medicine’s content from each microcapsule were treated with Minitab 14 software to obtain optimum [gg] and [glu] for microencapsulation. The dissolution behaviour of optimum ketoprofen and infar microcapsules were investigated. The result of optimization by using Minitab Release 14 software showed that among the microcapsule compositions of [gg] and [glu] were 0.35% (w/v) and 3.75% (v/v), respectively, optimum to coat ketoprofen, whereas [gg] and [glu] of 0.05% (w/v) and4.00% (v/v), respectively, optimum to coat infar, at constant chitosan concentration (1.75% [w/v]). In vitro dissolution profile showed that chitosan-guar gum gel microcapsule was more resistant in intestinal pH condition (rather basic) compared with that in gastric pH (very acidic).

Effect of Norfloxacin Complexation with β-Cyclodextrin on the in Vitro Dissolution Behaviour and its Interaction with Mg2+ and Al3+

1998 ◽  
Vol 51 (3) ◽  
pp. 1009-1021 ◽  
Author(s):  
J. J. Torres-Labandeira ◽  
P. de Labra Piñón ◽  
B. Pérez-Marcos ◽  
C. Alvarez-Lorenzo ◽  
J. L. Vila-Jato
Keyword(s):  
In Vitro Dissolution ◽  
Dissolution Behaviour

X-Ray Peak Broadening and In Vitro Dissolution Studies of Thermally Stabilized Nanocrystalline Carbonated Hydroxyapatite

2011 ◽  
Vol 493-494 ◽  
pp. 739-745 ◽  
Author(s):  
K. Pavankumar ◽  
K. Venkateswarlu ◽  
N. Rameshbabu ◽  
V. Muthupandi
Keyword(s):  
Dislocation Density ◽  
Crystallite Size ◽  
Synthesis Method ◽  
In Vitro Dissolution ◽  
Carbonated Hydroxyapatite ◽  
X Ray ◽  
Study Results ◽  
Dissolution Behaviour ◽  
Powder Particles

The present work aims to examine the effect of silicon substitution on thermal and in-vitro dissolution properties of carbonated hydroxyapatite. Hydroxyapatite [Ca10(PO4)6(OH)2, HA], carbonate substituted hydroxyapatite [Ca10(PO4)6-x(CO3)x(OH)2, x=1, 1CHA] and carbonate, silicate co-substituted hydroxyapatite [Ca10(PO4)6-x-y(CO3)x(SiO4)y(OH)2, x=1,y=1, 1C1SiHA] nanoparticles were prepared by microwave synthesis method under identical processing conditions. The XRD results of HA, 1CHA and 1C1SiHA correspond to the standard hexagonal HA (JCPDS 9-432). The crystallite size and lattice strain of the synthesized powder particles were estimated by Williamson-Hall isotropic strain model (W-H ISM) from powder X-ray diffraction data. The dislocation density was calculated by Williamson-Smallman formula. The functional groups present in the as-synthesized powder particles were analyzed by Fourier transform infrared (FT-IR) spectroscopy method. The size and the morphology were examined using a transmission electron microscope (TEM). The in-vitro dissolution behaviour of the synthesized powder particles was studied by ethylenediamine tetra-acetic acid (EDTA) titrimetric method. The W-H ISM results confirm that the prepared powder particles of HA, 1CHA and 1C1SiHA are nanocrystalline with an average crystallite size of 40 nm, 36 nm and 32 nm, respectively. Thus the crystallite size of hydroxyapatite was observed to be decreased gradually with increase in substitutions as indicated by the least size for the 1C1SiHA. In addition, the XRD results of powders annealed at 900 °C for 2 h show the improved thermal stability of 1C1SiHA compared to 1CHA. The TEM results show rod-like shaped morphology for HA, near rod-like with modified edge morphology and increased agglomeration for 1CHA and needle-like shaped morphology for 1C1SiHA powder particles. The in-vitro dissolution study results show a gradual increase in the solubility of HA with carbonate and carbonate-silicate co-substitutions. The calculated microstructural parameters, namely, crystallite size, root mean squared strain and dislocation density were correlated with in-vitro dissolution behaviour of hydroxyapatites.

scholarly journals Physicochemical characterization and in vitro dissolution behaviour of celecoxib-β-cyclodextrin inclusion complexes

2007 ◽  
Vol 57 (1) ◽  
pp. 47-60 ◽  
Author(s):  
Vivek Sinha ◽  
R. Anitha ◽  
Soma Ghosh ◽  
Rachana Kumria ◽  
Jayant Bhinge ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Inclusion Complexes ◽  
Physicochemical Characterization ◽  
Aqueous Solubility ◽  
In Vitro Dissolution ◽  
Cyclodextrin Inclusion Complexes ◽  
Cyclodextrin Inclusion ◽  
Dissolution Behaviour ◽  
Poorly Soluble

Physicochemical characterization and in vitro dissolution behaviour of celecoxib-β-cyclodextrin inclusion complexes In this study, attempts were made to investigate the effects of β-cyclodextrin (β-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.

scholarly journals Perilaku Disolusi Ketoprofen Tersalut Gel Kitosan-Karboksimetilselulosa (CMC)

2012 ◽  
Vol 13 (1) ◽  
pp. 21
Author(s):  
Purwantiningsih Sugita ◽  
Suminar Setiati Achmadi ◽  
Yuyu Yundhana
Keyword(s):  
Guar Gum ◽  
Tween 80 ◽  
Chitosan Solution ◽  
In Vitro Dissolution ◽  
Dissolution Profile ◽  
Drying Process ◽  
Dissolution Behaviour ◽  
Before And After ◽  
Sem Morphology

Study dissolution behaviour of ketoprofen through optimum chitosan-CMC microcapsule has been carried out. Into228.6 ml of 1.0% (w/v) chitosan solution in 1% (v/v) acetic acid, 38.1 ml of CMC solution was added with concentrationvariation of 0.075; 0.0875; and 0.10% (w/v). Afterwards, 7.62 mL of glu was added slowly under stirring, withconcentrations varied: 3; 4.5; and 6% (v/v). All mixtures were shaked for 20 minutes for homogenization. Into eachmicrocapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added. Everymixture was then added with 5 ml of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature.Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. Thedissolution behaviour of optimum ketoprofen microcapsules were investigated in gastric and intestinal medium.Microcapsule morphology before and after dissolution as well as empty microcapsule (blank) were observed withSEM. Spray drying process had successfully coated ketoprofen in chitosan-CMC microcapsule. Optimization byusing Minitab Release 14 software showed that among the microcapsule compositions studied, CMC and glu of0.0925% (w/v) and 3.01% (v/v), respectively, optimum to coat ketoprofen at constant chitosan concentration 1.0%(w/v). Result of SEM morphology and In vitro dissolution profile showed that ketoprofen in chitosan-CMCmicrocapsule was relatively well than chitosan-guar gum microcapsule. Kinetically, dissolution of ketoprofen frommicrocapsule in intestinal pH condition was first order with release rate constant, k, of 7.285  10-4 % min-1 andrelease half-time, t1/2, of approximately 15 hours.

scholarly journals Enhancement of Dissolution Rate and Bioavailability of Nifedipine by Chitosan Based Cocrystallization Technique

2021 ◽  
pp. 206-219
Author(s):  
. Reetu ◽  
Ashutosh Yadav ◽  
Anita Singh ◽  
Arun Garg
Keyword(s):  
Dissolution Rate ◽  
Sodium Citrate ◽  
Chitosan Solution ◽  
In Vitro Dissolution ◽  
Salting Out ◽  
Design Expert ◽  
Dissolution Behaviour ◽  
Main Effects

The objective of present study was to enhance solubility and dissolution behaviour of nifedipine by using cocrystallization method. A significant increase in solubility and dissolution rate of nifedipine has been demonstrated by solvent change method using chitosan. In this method, chitosan was precipitated on nifedipine crystals using sodium citrate as a salting out agent. An accurately weighed chitosan was dissolved in 1% acetic acid and drug was added in the chitosan solution. This resulting solution was added drop wise into 1% sodium citrate solution with continuous stirring. Sodium citrate precipitate polymer on drug crystals. FTIR, DSC, XRD, SEM, In-vitro dissolution studies, were studied for characterization of prepared cocrystals. Stability studies showed a good stability character of prepared cocrystals. Design Expert® software version 10.0 was used to develop polynomial models which were analysed to delineate the main effects for each CQA (critical quality attributes) through Box-Bhenken design expert. Pharmacokinetic study clearly showed the enhancement of dissolution rate of cocrystals. The above investigation concluded that the significant dose reduction is possible for nifedipine with cocrystal formulation which leads to improve patient compliance.

Sign in / Sign up

Export Citation Format

Share Document