Influence of ω3 fatty acids on maternal behavior and brain oxytocin in the murine perinatal period

2022 ◽  
Vol 176 ◽  
pp. 102386
Author(s):  
Akiko Harauma ◽  
Shunichi Nakamura ◽  
Natsuko Wakinaka ◽  
Kazutaka Mogi ◽  
Toru Moriguchi
Keyword(s):  
Fatty Acids ◽  
Maternal Behavior ◽  
Perinatal Period ◽  
Ω3 Fatty Acids

The influence of n-3 fatty acids on maternal behavior and brain monoamines in the perinatal period

2016 ◽  
Vol 107 ◽  
pp. 1-7 ◽  
Author(s):  
Akiko Harauma ◽  
Takayuki Sagisaka ◽  
Taku Horii ◽  
Yoshitake Watanabe ◽  
Toru Moriguchi
Keyword(s):  
Fatty Acids ◽  
Maternal Behavior ◽  
Perinatal Period ◽  
Brain Monoamines

Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

1985 ◽  
Vol 54 (03) ◽  
pp. 563-569 ◽  
Author(s):  
M K Salo ◽  
E Vartiainen ◽  
P Puska ◽  
T Nikkari
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Free Living ◽  
Ω3 Fatty Acids ◽  
Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

Ω3 Fatty Acids Activate Ciliary FFAR4 to Trigger Adipogenesis in Perivascular Preadipocytes

2018 ◽  
Author(s):  
Keren I. Hilgendorf ◽  
Carl T. Johnson ◽  
Anja Mezger ◽  
Janos Demeter ◽  
William J. Greenleaf ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Ω3 Fatty Acids

scholarly journals Inclusion of Soluble Fiber in the Gestation Diet Changes the Gut Microbiota, Affects Plasma Propionate and Odd-Chain Fatty Acids Levels, and Improves Insulin Sensitivity in Sows

2020 ◽  
Vol 21 (2) ◽  
pp. 635 ◽  
Author(s):  
Chuanhui Xu ◽  
Chuanshang Cheng ◽  
Xiu Zhang ◽  
Jian Peng
Keyword(s):  
Fatty Acids ◽  
Insulin Sensitivity ◽  
Gut Microbiota ◽  
Systemic Inflammation ◽  
Guar Gum ◽  
Dietary Treatment ◽  
Perinatal Period ◽  
Soluble Fiber ◽  
Odd Chain Fatty Acids ◽  
Chain Fatty Acids

The transition from pregnancy to lactation is characterized by a progressive decrease in insulin sensitivity. Propionate increases with dietary fiber consumption and has been shown to improve insulin sensitivity. Recent studies suggest that plasma odd-chain fatty acids [OCFAs; pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0)] that inversely correlated with insulin resistance are synthesized endogenously from gut-derived propionate. The present study investigated the effects of soluble fiber during gestation on gut microbiota, plasma non-esterified fatty acids and insulin sensitivity in sows. Sows were allocated to either control or 2.0% guar gum plus pregelatinized waxy maize starch (SF) dietary treatment during gestation. The SF addition changes the structure and composition of gut microbiota in sows. Genus Eubacterium increased by SF addition may promote intestinal propionate production. Moreover, the dietary SF increased circulating levels of plasma OCFAs, especially C17:0. The SF-fed sows had a higher insulin sensitivity and a lower systemic inflammation level during perinatal period. Furthermore, the plasma C15:0 and C17:0 was negatively correlated with the area under curve of plasma glucose after meal and plasma interleukin-6. In conclusion, dietary SF improves insulin sensitivity and alleviates systemic inflammation in perinatal sows, potentially related to its stimulating effect on propionate and OCFAs production.

Effect of ω3 fatty acids on oxidative stress in humans: GC–MS measurement of urinary F2-isoprostane excretion

Redox Report ◽  
2000 ◽  
Vol 5 (1) ◽  
pp. 45-46 ◽  
Author(s):  
T.A. Mori ◽  
I.B. Puddey ◽  
V. Burke ◽  
K.D. Croft ◽  
D.W. Dunstan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Ω3 Fatty Acids

Gender-related long-term effects in adult rats by perinatal dietary ratio of n-6/n-3 fatty acids

2005 ◽  
Vol 288 (3) ◽  
pp. R575-R579 ◽  
Author(s):  
Marina Korotkova ◽  
Britt G. Gabrielsson ◽  
Agneta Holmäng ◽  
Britt-Marie Larsson ◽  
Lars Å. Hanson ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Linseed Oil ◽  
Maternal Diet ◽  
Perinatal Period ◽  
Late Gestation ◽  
Male Rats ◽  
Long Term Effects ◽  
Adult Rats ◽  
Serum Leptin

Epidemiological studies in humans have shown that perinatal nutrition affects health later in life. We have previously shown that the ratio of n-6 to n-3 polyunsaturated fatty acids (PUFA) in the maternal diet affects serum leptin levels and growth of the suckling pups. The aim of the present study was to investigate the long-term effects of various ratios of the dietary n-6 and n-3 PUFA during the perinatal period on serum leptin, insulin, and triacylglycerol, as well as body growth in the adult offspring. During late gestation and throughout lactation, rats were fed an isocaloric diet containing 7 wt% fat, either as linseed oil (n-3 diet), soybean oil (n-6/n-3 diet), or sunflower oil (n-6 diet). At 3 wk of age, the n-6/n-3 PUFA ratios in the serum phospholipids of the offspring were 2.5, 8.3, and 17.5, respectively. After weaning, all pups were given a standard chow. At the 28th postnatal wk, mean body weight and fasting insulin levels were significantly increased in the rats fed the n-6/n-3 diet perinatally compared with the other groups. The systolic blood pressure and serum triacylglycerol levels were only increased in adult male rats of the same group. These data suggest that the balance between n-6 and n-3 PUFA during perinatal development affects several metabolic parameters in adulthood, especially in the male animals.

Oleogel-structured composite for the stabilization of ω3 fatty acids in fish oil

2018 ◽  
Vol 9 (11) ◽  
pp. 5598-5606 ◽  
Author(s):  
Michelle C. Lee ◽  
Xiaofei Jiang ◽  
J. Thomas Brenna ◽  
Alireza Abbaspourrad
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Whey Protein ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Compartment System ◽  
Cyclodextrin Complexation ◽  
Ω3 Fatty Acids

The fish oil is encapsulated in a multi-compartment system featuring β-cyclodextrin complexation within whey protein isolate (WPI) coated oleogel particles.

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