Oral administration of freeze-dried powders of honey bee larvae inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice

2017 ◽  
Vol 6 ◽  
pp. 22-27 ◽  
Author(s):  
Masakatsu Kageyama ◽  
Guoqing Xing ◽  
Kejuan Li ◽  
Zhenya Zhang ◽  
Akihiko Sugiyama
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Honey Bee ◽  
Skin Lesions ◽  
Freeze Dried ◽  
Honey Bee Larvae

scholarly journals Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Dermatophagoides farinae Extract-Induced BALB/c Mice

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4409
Author(s):  
Jinjoo Kang ◽  
Soyoung Lee ◽  
Namkyung Kim ◽  
Hima Dhakal ◽  
Taeg-Kyu Kwon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Diseases ◽  
Nuclear Translocation ◽  
Skin Lesions ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Dermatophagoides Farinae ◽  
Tnf Α ◽  
Ifn Γ

The extracts of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) have various therapeutic effects, including inflammation and allergy. In this study, gomisin M2 (GM2) was isolated from S. chinensis and its beneficial effects were assessed against atopic dermatitis (AD). We evaluated the therapeutic effects of GM2 on 2,4-dinitrochlorobenzene (DNCB) and Dermatophagoides farinae extract (DFE)-induced AD-like skin lesions with BALB/c mice ears and within the tumor necrosis factor (TNF)-α and interferon (IFN)-γ-stimulated keratinocytes. The oral administration of GM2 resulted in reduced epidermal and dermal thickness, infiltration of tissue eosinophils, mast cells, and helper T cells in AD-like lesions. GM2 suppressed the expression of IL-1β, IL-4, IL-5, IL-6, IL-12a, and TSLP in ear tissue and the expression of IFN-γ, IL-4, and IL-17A in auricular lymph nodes. GM2 also inhibited STAT1 and NF-κB phosphorylation in DNCB/DFE-induced AD-like lesions. The oral administration of GM2 reduced levels of IgE (DFE-specific and total) and IgG2a in the mice sera, as well as protein levels of IL-4, IL-6, and TSLP in ear tissues. In TNF-α/IFN-γ-stimulated keratinocytes, GM2 significantly inhibited IL-1β, IL-6, CXCL8, and CCL22 through the suppression of STAT1 phosphorylation and the nuclear translocation of NF-κB. Taken together, these results indicate that GM2 is a biologically active compound that exhibits inhibitory effects on skin inflammation and suggests that GM2 might serve as a remedy in inflammatory skin diseases, specifically on AD.

Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-γ down-regulation in NC/Nga mice

2009 ◽  
Vol 122 (3) ◽  
pp. 567-572 ◽  
Author(s):  
Dong-Young Kim ◽  
Jung-A Jung ◽  
Tae-Ho Kim ◽  
Sang-Wan Seo ◽  
Sung-Ki Jung ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Lesions ◽  
Down Regulation ◽  
Ifn Γ

Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice

2003 ◽  
Vol 3 (9) ◽  
pp. 1313-1324 ◽  
Author(s):  
Yoshifumi Taniguchi ◽  
Keizo Kohno ◽  
Shin-ichiro Inoue ◽  
Satomi Koya-Miyata ◽  
Iwao Okamoto ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Royal Jelly ◽  
Skin Lesions

scholarly journals Oral Administration of Acidic Xylooligosaccharides Prevents the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

2010 ◽  
Vol 56 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Takayuki OHBUCHI ◽  
Makoto SAKAINO ◽  
Tetsunari TAKAHASHI ◽  
Naoya AZUMI ◽  
Kotaro ISHIKAWA ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Lesions

scholarly journals Oral Administration of the Extract from Hatakeshimeji (Lyophyllum decastes Sing.) Mushroom Inhibits the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

2007 ◽  
Vol 53 (3) ◽  
pp. 293-296 ◽  
Author(s):  
Yuuichi UKAWA ◽  
Yoshiya IZUMI ◽  
Takayuki OHBUCHI ◽  
Tetsunari TAKAHASHI ◽  
Shoichi IKEMIZU ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Lesions ◽  
Lyophyllum Decastes

scholarly journals Oral Administration of SSC201, a Medicinal Herbal Formula, Suppresses Atopic Dermatitis-Like Skin Lesions

2014 ◽  
Vol 17 (4) ◽  
pp. 496-504 ◽  
Author(s):  
Bo-Kyung Park ◽  
Yang-Chun Park ◽  
In Chul Jung ◽  
Seung-Hyung Kim ◽  
Jung-Eun Choi ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Lesions ◽  
Herbal Formula
Sign in / Sign up

Export Citation Format

Share Document