Schneiderian first rank symptoms and inferior parietal lobule cortical thickness in antipsychotic-naïve schizophrenia

2011 ◽  
Vol 35 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Ganesan Venkatasubramanian ◽  
Peruvumba N. Jayakumar ◽  
Matcheri S. Keshavan ◽  
Bangalore N. Gangadhar
Keyword(s):  
Cortical Thickness ◽  
Inferior Parietal Lobule ◽  
Parietal Lobule ◽  
First Rank Symptoms

scholarly journals 0014 Reduced Cortical Thickness as a Biomarker of Daytime Sleepiness in Mild Traumatic Brain Injury

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A5-A6
Author(s):  
N S Dailey ◽  
A C Raikes ◽  
A Alkozei ◽  
M A Grandner ◽  
W D Killgore
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Cortical Thickness ◽  
Daytime Sleepiness ◽  
Healthy Controls ◽  
Inferior Parietal Lobule ◽  
Post Injury ◽  
Attention Network ◽  
Parietal Lobule

Abstract Introduction Sleep disruptions, including the increase of daytime sleepiness, are reported in roughly 70% of all individuals who have suffered a mild traumatic brain injury (mTBI). Prior research using magnetic resonance imaging (MRI) has identified associations between functional brain changes and daytime sleepiness following mTBI. In the present study, we aimed to identify whether structural differences in cortical thickness are associated with increased daytime sleepiness in adults with mTBI. Methods A total of 58 adults between 18 and 45 years of age (M=23.58±5.31) participated in the study, including 19 healthy controls and 39 individuals with a documented mTBI. Individuals with mTBI were further divided based on time-since-injury into a sub-acute (n=22) or chronic (n=17) group. Daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS) and cortical thickness was measured using high-resolution T1-weighted structural MRI. Whole-brain vertex-wise estimations of cortical thickness were calculated using FreeSurfer (v.6.0) and entered into a GLM to identify between-group differences in cortical thickness and the association with ESS. Results Significant differences in cortical thickness were found between the two mTBI groups (cluster-forming threshold p<.01; cluster-wise threshold p<.05; two-tailed; FWE-corrected). Specifically, lower cortical thickness in the left hemisphere was found in the inferior parietal lobule (p=.01), precuneus (p=.03), and pars triangularis (p=.04) for the sub-acute, compared to chronic group. Furthermore, a significant negative correlation was found between ESS and cortical thickness in the inferior parietal lobule (r=-.55, p=.009) for the sub-acute mTBI group. Conclusion More daytime sleepiness was associated with reduced inferior parietal cortical thickness in those 2 to 12-weeks post-injury, an association not observed in those 6 to 12-months post-injury or healthy controls. The inferior parietal lobule is part of the frontoparietal attention network and has been associated with vulnerability to sleep loss. Our findings suggest structural damage to the attention network following mTBI may be one factor affecting daytime sleepiness in mTBI. These findings may reflect a potential biomarker of sleep disturbances in mTBI. Support USAMRMC grant (W81XWH-12–0386).

Planum parietale volume in antipsychotic-naïve schizophrenia

2011 ◽  
Vol 26 (S2) ◽  
pp. 1505-1505
Author(s):  
V. Shivakumar ◽  
S.V. Kalmady ◽  
G. Venkatasubramanian ◽  
S. Gautham ◽  
S. Aditi ◽  
...  
Keyword(s):  
Parietal Lobe ◽  
Healthy Controls ◽  
Inferior Parietal Lobule ◽  
Time Study ◽  
Female Patients ◽  
Male Patients ◽  
Parietal Lobule ◽  
First Rank Symptoms ◽  
First Time

IntroductionFirst Rank Symptoms (FRS) - a group of intriguing experiences characterized by striking breach of ‘self versus non-self’ boundaries - have had a critical influence on the diagnosis of schizophrenia. Inferior Parietal Lobule is implicated in the pathogenesis of FRS in Schizophrenia. However, the role of Planum Parietale (PP) in the genesis of FRS is yet to be examined.Aims & objectivesThis first time study (to the best of our knowledge), aims to examine antipsychotic-naïve schizophrenia patients for the effect of FRS status on volume of PP.MethodIn this study we examined the volume of PP in antipsychotic-naïve schizophrenia patients (n = 32; M:F = 16:16) in comparison with age, sex, and handedness matched (as a group) healthy comparison subjects (n = 34; M:F = 16:18) using valid method with good inter-rater reliability.ResultsFemale Schizophrenia patients showed significant volume reduction in right PP in comparison with female healthy controls (F = 7.2; p = 0.01). However, male patients did not. There was a significant effect of schneiderian FRS in female patients in that those who had FRS had significantly smaller volume of right PP than healthy controls (F = 3.8; p = 0.03); where those female patients who were FRS negative did not differ. Left PP volume did not differ between patients and controls.ConclusionsCurrent study supports previous studies which have implicated the role of parietal lobe in pathogenesis of FRS. Specific role of PP in FRS generation and possible implication of sex differences needs further systematic studies.

scholarly journals Inferior Parietal Lobule Volume and Schneiderian First-Rank Symptoms in Antipsychotic-Naïve Schizophrenia: A 3-Tesla MRI Study

2009 ◽  
Vol 31 (2) ◽  
pp. 82-87 ◽  
Author(s):  
Vijay Danivas ◽  
Sunil Kalmady ◽  
Rashmi Arasappa ◽  
Rishikesh V. Behere ◽  
Naren P. Rao ◽  
...  
Keyword(s):  
3 Tesla ◽  
Inferior Parietal Lobule ◽  
3 Tesla Mri ◽  
Parietal Lobule ◽  
Mri Study ◽  
First Rank Symptoms

Reduced cortical thickness in subjects at clinical high risk for psychosis and clinical attributes

2018 ◽  
Vol 53 (3) ◽  
pp. 219-227 ◽  
Author(s):  
Yoo Bin Kwak ◽  
Minah Kim ◽  
Kang Ik Kevin Cho ◽  
Junhee Lee ◽  
Tae Yong Lee ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
High Risk ◽  
Cortical Thickness ◽  
Clinical Symptoms ◽  
Inferior Parietal Lobule ◽  
Clinical High Risk ◽  
Prodromal Symptoms ◽  
Youth Clinic ◽  
Parietal Lobule ◽  
The Right

Objectives: Although neuroanatomical abnormalities in subjects at clinical high risk for psychosis have been considered a putative biomarker of psychosis, relevance of cortical thickness alterations remains contested due to discrepant findings. Inconsistencies persist in Asian clinical high risk studies, despite their advantageous settings well-controlled for confounds. Attributes of cortical thickness alterations in clinical high risk subjects warrant further examination. Methods: We examined cortical thickness at the whole-brain level in 74 clinical high risk subjects and 34 demographically matched healthy controls recruited from Seoul Youth Clinic, South Korea. Clinical symptoms were assessed using the Scale of Prodromal Symptoms, and their associations with cortical thickness were explored using partial correlation analysis. Results: Compared to healthy control, clinical high risk exhibited significant cortical thinning in bilateral prefrontal cortex and inferior parietal lobule clusters. Reduced thickness in the left prefrontal cortex cluster was associated with more severe Scale of Prodromal Symptoms general symptoms scores and the right inferior parietal lobule cluster with Scale of Prodromal Symptoms disorganization symptoms. Conclusions: Thickness deficits found in the present clinical high risk sample demonstrated a degree of consistency with those reported in the previous Seoul Youth Clinic study. While inconsistencies reported between the present and previous Seoul Youth Clinic samples may reflect markedly decreased rate of converters, consistencies may be relevant to clinical attributes beyond transition, such as the prevalence of comorbidities. Particular recruitment strategies employed for sample selections should also be considered for findings in Asian clinical high risk samples. Our results suggest potential utility of cortical thickness alterations in clinical high risk subjects beyond the frame of transition.

scholarly journals Organization of the macaque monkey inferior parietal lobule based on multimodal receptor architectonics

NeuroImage ◽  
2021 ◽  
Vol 231 ◽  
pp. 117843 ◽  
Author(s):  
Meiqi Niu ◽  
Lucija Rapan ◽  
Thomas Funck ◽  
Seán Froudist-Walsh ◽  
Ling Zhao ◽  
...  
Keyword(s):  
Macaque Monkey ◽  
Inferior Parietal Lobule ◽  
Parietal Lobule

Neuroimaging correlates of insight in obsessive compulsive disorder: A fMRI study

2017 ◽  
Vol 41 (S1) ◽  
pp. S409-S409
Author(s):  
A. Gadad ◽  
D.Y.C.J. Reddy ◽  
D.G. Venkatasubramanian ◽  
D.J. C.N
Keyword(s):  
Mental Rotation ◽  
Negative Correlation ◽  
Mental Rotation Task ◽  
Healthy Controls ◽  
Inferior Parietal Lobule ◽  
Good Insight ◽  
Compulsive Disorder ◽  
Accuracy Ratio ◽  
Parietal Lobule ◽  
Medial Frontal Gyrus

Aim of the studyTo study the neural substrates of insight in OCD by comparing patients with good insight, patients with poor insight and matched healthy controls using functional MRI.MethodologySubjects were recruited from among patients attending OCD clinic, adult psychiatry services and psychiatry ward inpatients of National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore. They were further divided into ‘good insight’ (n = 30) and ‘poor insight’ (n = 14) using Brown's assessment of belief's scale. Control subjects (n = 30) were recruited from consenting volunteers. 3 T MRI was used mental rotation task was paradigm used for fMRI and analysis was done by SPM 8.ResultsPoor insight patients and good insight patients comparison revealed differential activation in left superior/medial frontal gyrus (corresponding to the DLPFC). A negative correlation between BABS score and activation of right inferior parietal lobule. Mental rotation task behavioural data results: OCD patients as a group had significantly lower accuracy compared to healthy controls. Poor insight group had significantly decreased accuracy ratio compared to good insight group and healthy controls. A negative correlation was noted between BABS score and accuracy ratio, indicating that poorer the insight, greater the errors during the active task.ConclusionInsight has been important prognostic factor in OCD. Poor insight patients had specific deficits in left medial frontal gyrus and right inferior parietal lobule as compared to good insight patients and healthy controls. Together, these indicate that insight has a strong neurobiological underpinning in OCD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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