scholarly journals Bis-tridentate chelates of an asymmetric ligand: X-ray structures and solution NMR characterization of divalent zinc triad metal ion complexes of N-(2-pyridylmethyl)-N-(2-(methylthio)ethyl)amine

Polyhedron ◽  
2008 ◽  
Vol 27 (6) ◽  
pp. 1591-1600 ◽  
Author(s):  
Deborah C. Bebout ◽  
Wei Lai ◽  
Sarah M. Stamps ◽  
Steven M. Berry ◽  
Raymond J. Butcher
Keyword(s):  
Metal Ion ◽  
Solution Nmr ◽  
Metal Ion Complexes ◽  
X Ray ◽  
Nmr Characterization ◽  
Ethyl Amine

Zinc triad metal ion complexes ofNN′S ligandN-(2-pyridylmethyl)-N-(2-(methylthio)ethyl)amine

2007 ◽  
Vol 6 (3-4) ◽  
pp. 155-168 ◽  
Author(s):  
Deborah C. Bebout ◽  
Wei Lai ◽  
Sarah M. Stamps ◽  
Steven M. Berry ◽  
Raymond J. Butcher
Keyword(s):  
Metal Ion ◽  
Metal Ion Complexes ◽  
Ethyl Amine

scholarly journals Evidence that the TRPV1 S1-S4 Membrane Domain Contributes to Thermosensing

2019 ◽  
Author(s):  
Minjoo Kim ◽  
Nicholas J. Sisco ◽  
Jacob K. Hilton ◽  
Camila M. Montano ◽  
Manuel A. Castro ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Solution Nmr ◽  
Membrane Domain ◽  
Temperature Dependent ◽  
Nmr Characterization ◽  
Significant Interest ◽  
Pore Domain ◽  
Coupling Mechanisms

AbstractSensing and responding to temperature is crucial in biology. The TRPV1 ion channel is a well-studied heat-sensing receptor that is also activated by vanilloid compounds including capsaicin. Despite significant interest, the molecular underpinnings of thermosensing have remained elusive. The TRPV1 S1-S4 membrane domain couples chemical ligand binding to the pore domain during channel gating. However, the role of the S1-S4 domain in thermosensing is unclear. Evaluation of the isolated human TRPV1 S1-S4 domain by solution NMR, Far-UV CD, and intrinsic fluorescence shows that this domain undergoes a non-denaturing temperature-dependent transition with a high thermosensitivity. Further NMR characterization of the temperature-dependent conformational changes suggests the contribution of the S1-S4 domain to thermosensing shares features with known coupling mechanisms between this domain with ligand and pH activation. Taken together, this study shows that the TRPV1 S1-S4 domain contributes to TRPV1 temperature-dependent activation.

Preparation and characterization of Tl(1,2-C2H4Cl2)B(OTeF5)4: a metal complex of a least coordinating solvent and a least coordinating anion

1992 ◽  
Vol 70 (3) ◽  
pp. 726-731 ◽  
Author(s):  
Paul K. Hurlburt ◽  
Oren P. Anderson ◽  
Steven H. Strauss
Keyword(s):  
Metal Ion ◽  
Chelate Ring ◽  
Ion Solvation ◽  
Crystalline Compound ◽  
Triclinic Space Group ◽  
X Ray ◽  
X Ray Crystallography ◽  
Solid Salt ◽  
Solvent Metal

Addition of B(OTeF5)3 to TIOTeF5 in the weakly coordinating solvents dichloromethane, 1,2-dichloroethane, and 1,1,2-trichlorotrifluoroethane produces solutions of M(solv)x+B(OTeF5)4−. When the solvent was 1,2-dichloroethane, the crystalline compound Tl(1,2-C2H4Cl2)B(OTeF5)4 was isolated and studied by X-ray crystallography: triclinic, space group [Formula: see text], a = 9.221 (4), b = 11.396(5), c = 12.538 (4) Å, α = 110.75 (3)°, β = 101.72(3)°, γ = 99.74 (3)°, Z = 2, T = −116 °C. The Tl(1,2-C2H4Cl2)+ cation contains a five-membered chelate ring with Tl—Cl distances of 3.138 (4) and 3.179 (3) Å. The metal ion is weakly bonded to four B(OTeF5)4− counterions, with nine Tl—F interactions that range from 2.950 (5) to 3.981 (8) Å. When the solvent is dichloromethane or 1,1,2-trichlorotrifluoroethane, only the unsolvated solid salt TlB(OTeF5)4 can be isolated by crystallization. This salt is thermally unstable, slowly forming TlOTeF5 and volatile B(OTeF5)3. Keywords: noncoordinating anion, noncoordinating solvent, metal ion solvation.

Hexa Schiff-base cryptands: solution thermodynamic and X-ray crystallographic studies of main group, transition and heavy metal ion complexes

1996 ◽  
pp. 2747-2755 ◽  
Author(s):  
Rym Abidi ◽  
Françoise Arnaud-Neu ◽  
Michael G. B. Drew ◽  
Sarah Lahély ◽  
Debbie Marrs ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Schiff Base ◽  
Metal Ion ◽  
Main Group ◽  
Heavy Metal Ion ◽  
Metal Ion Complexes ◽  
X Ray

Approaches to the Solution NMR Characterization of Active Sites for 65 kDa Tetrameric Hemoglobins in the Paramagnetic Cyanomet State

1997 ◽  
Vol 119 (51) ◽  
pp. 12643-12654 ◽  
Author(s):  
Urszula Kolczak ◽  
Chang Han ◽  
L. A. Sylvia ◽  
Gerd N. La Mar
Keyword(s):  
Active Sites ◽  
Solution Nmr ◽  
Nmr Characterization

A Calix[6]arene Receptor Rigidified by a Self-assembled Triammonium Cap: X-ray and NMR Characterization of the Binding of Polar Neutral Guests

2005 ◽  
Vol 17 (3) ◽  
pp. 243-250 ◽  
Author(s):  
Ulrich Darbost ◽  
Michel Giorgi ◽  
Nicolas Hucher ◽  
Ivan Jabin * ◽  
Olivia Reinaud *
Keyword(s):  
X Ray ◽  
Nmr Characterization ◽  
Self Assembled

scholarly journals Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

2015 ◽  
Vol 472 (1) ◽  
pp. 121-133 ◽  
Author(s):  
Prem Raj B. Joseph ◽  
Philip D. Mosier ◽  
Umesh R. Desai ◽  
Krishna Rajarathnam
Keyword(s):  
Structural Plasticity ◽  
Neutrophil Function ◽  
Solution Nmr ◽  
Binding Interactions ◽  
High Affinity ◽  
Nmr Characterization ◽  
Differential Binding

Structural plasticity plays a major role in determining differential binding of CXCL8 monomer and dimer to glycosaminoglycans (GAGs) and that dimer is the high-affinity GAG ligand. We propose that these properties play important roles in orchestrating in vivo chemokine-mediated neutrophil function.

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