Investigations into a change of aryl group on the cytotoxicity and anti-leishmanial activity of a series of tris-aryl Sb(V) pentafluoropropionates

The straightforward synthesis and photophysical properties of a new series of heteroleptic Iridium (III) bis(2-arylimidazole) picolinate complexes is reported. Each complex has been characterized by NMR, UV-Vis, cyclic voltammetry, and the emissive properties of each is described. By systematically modifying first the cyclometallating aryl group on the arylimidazole ligand and then the picolinate ligand, the ramifications of ligand modification in these complexes was better understood through the construction of a structure-property relationship.

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Exploration of Bis(Arylimidazole) Iridium Picolinate Complexes

10.26434/chemrxiv.5331460 ◽

2017 ◽

Author(s):

Aron Huckaba ◽

sadig aghazada ◽

iwan zimmermann ◽

giulia grancini ◽

natalia gasilova ◽

...

Keyword(s):

Cyclic Voltammetry ◽

Photophysical Properties ◽

Structure Property ◽

Aryl Group ◽

Ligand Modification ◽

Property Relationship ◽

Structure Property Relationship

The straightforward synthesis and photophysical properties of a new series of heteroleptic Iridium (III) bis(2-arylimidazole) picolinate complexes is reported. Each complex has been characterized by NMR, UV-Vis, cyclic voltammetry, and the emissive properties of each is described. By systematically modifying first the cyclometallating aryl group on the arylimidazole ligand and then the picolinate ligand, the ramifications of ligand modification in these complexes was better understood through the construction of a structure-property relationship.

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Electronic or steric effects: Detailed DFT investigations of titanium amino based Kaminsky type olefin catalysts

10.26434/chemrxiv.7530854 ◽

2018 ◽

Author(s):

Jörg Saßmannshausen

Keyword(s):

Density Functional Theory ◽

Strong Correlation ◽

Density Functional ◽

Steric Effects ◽

Aryl Group ◽

Functional Theory

We report detailed Density Functional Theory (DFT) investigations of a series of structurally similar titanium (IV) chelating σ-aryl catalysts. Particular attention was paid to the electronic charges of the Ti, C ipso of the substituted aryl group and the benzylic CH2 and Cipso atoms. The Bader and NBO derived charges were compared with the recently reported polymerisation results by Chan. We found a strong correlation between the relative energies of one of the computed isomers and the activity of the catalyst. Neither NBO nor Bader charges could be convincingly correlated to the observed activity.

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Evaluation of Different Synthetic Routes to (2R,3R)-3-Hydroxymethyl-2-(4-hydroxy- 3-methoxyphenyl)-1,4-Benzodioxane-6-Carbaldehyde

Current Organic Chemistry ◽

10.2174/1385272823666191212113407 ◽

2020 ◽

Vol 23 (26) ◽

pp. 2960-2968

Author(s):

Renáta Kertiné Ferenczi ◽

Tünde-Zita Illyés ◽

Sándor Balázs Király ◽

Gyula Hoffka ◽

László Szilágyi ◽

...

Keyword(s):

Absolute Configuration ◽

Stereoselective Synthesis ◽

Cotton Effect ◽

Enantioselective Synthesis ◽

Aryl Group ◽

Target Molecule ◽

Synthetic Routes ◽

The Absolute

The reported enantioselective synthesis for the preparation of (+)-(2R,3R)-2-(4- hydroxy-3-methoxyphenyl)-3-hydroxymethyl-1,4-benzodioxane-6-carbaldehyde, precursor for the stereoselective synthesis of bioactive flavanolignans, could not be reproduced. Thus, the target molecule was prepared via the synthesis and separation of diastereomeric O-glucosides. TDDFT-ECD calculations and the 1,4-benzodioxane helicity rule were utilized to determine the absolute configuration. ECD calculations also confirmed that the 1Lb Cotton effect is governed by the helicity of the heteroring, while the higher-energy ECD transitions reflect mainly the orientation of the equatorial C-2 aryl group.

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Structural comparison of Acinetobacter baumannii β-ketoacyl-acyl carrier protein reductases in fatty acid and aryl polyene biosynthesis

Scientific Reports ◽

10.1038/s41598-021-86997-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Woo Cheol Lee ◽

Sungjae Choi ◽

Ahjin Jang ◽

Kkabi Son ◽

Yangmee Kim

Keyword(s):

Fatty Acid ◽

Acinetobacter Baumannii ◽

Gene Cluster ◽

Fatty Acid Synthase ◽

Acyl Carrier Protein ◽

Gene Clusters ◽

Carrier Protein ◽

Aryl Group ◽

Visible Absorption

AbstractSome Gram-negative bacteria harbor lipids with aryl polyene (APE) moieties. Biosynthesis gene clusters (BGCs) for APE biosynthesis exhibit striking similarities with fatty acid synthase (FAS) genes. Despite their broad distribution among pathogenic and symbiotic bacteria, the detailed roles of the metabolic products of APE gene clusters are unclear. Here, we determined the crystal structures of the β-ketoacyl-acyl carrier protein (ACP) reductase ApeQ produced by an APE gene cluster from clinically isolated virulent Acinetobacter baumannii in two states (bound and unbound to NADPH). An in vitro visible absorption spectrum assay of the APE polyene moiety revealed that the β-ketoacyl-ACP reductase FabG from the A. baumannii FAS gene cluster cannot be substituted for ApeQ in APE biosynthesis. Comparison with the FabG structure exhibited distinct surface electrostatic potential profiles for ApeQ, suggesting a positively charged arginine patch as the cognate ACP-binding site. Binding modeling for the aryl group predicted that Leu185 (Phe183 in FabG) in ApeQ is responsible for 4-benzoyl moiety recognition. Isothermal titration and arginine patch mutagenesis experiments corroborated these results. These structure–function insights of a unique reductase in the APE BGC in comparison with FAS provide new directions for elucidating host–pathogen interaction mechanisms and novel antibiotics discovery.

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Synthesis and Cytotoxic Activity of Several Novel N-Alkyl-Plinabulin Derivatives With Aryl Group Moieties

Natural Product Communications ◽

10.1177/1934578x211010040 ◽

2021 ◽

Vol 16 (4) ◽

pp. 1934578X2110100

Author(s):

Pham The Chinh ◽

Pham Thi Tham ◽

Duong Huong Quynh ◽

Nguyen Van Tuyen ◽

Dinh Thuy Van ◽

...

Keyword(s):

Cytotoxic Activity ◽

Cancer Cells ◽

Cell Lines ◽

Cancer Cell ◽

Aldol Condensation ◽

One Pot ◽

Aryl Group ◽

Vascular Disrupting Agents ◽

Benzaldehyde Derivatives ◽

Vascular Disrupting

Seven novel N-alkyl-plinabulin derivatives with aryl groups moieties (nitroquinoline, 1,4-dihydroquinoline, 4-methoxybenzene, and 4-chlorobenzene) have been synthesized via aldol condensation and alkylation in one-pot, and tested for their cytotoxicity against 4 cancer cell lines (KB, HepG2, Lu, and MCF7). Compounds ( Z)−3-((6,8-dimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)piperazine-2,5-dione (5a), ( Z)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)−3-((1,6,8-trimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)piperazine-2,5-dione (5b), and ( Z)−3-(( Z)−4-chlorobenzylidene)−1,4-dimethyl-6-((8-methyl-4-nitroquinolin-2-yl)methylene)piperazine-2,5-dione (8) showed strong cytotoxicity against 3 of the cancer cells lines (KB, HepG2 and Lu) with IC50 values ranging from 3.04 to 10.62 µM. The quinoline-derived compounds had higher cytotoxic activity than the benzaldehyde derivatives. The successful synthesis of these derivatives offers useful information for the development of more potent vascular disrupting agents based on plinabulin.

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The development of aryl-substituted 2-phenylimidazo[1,2-a]pyridines (PIP) with various colors of excited-state intramolecular proton transfer (ESIPT) luminescence in the solid state

Journal of Materials Chemistry C ◽

10.1039/c6tc00376a ◽

2016 ◽

Vol 4 (16) ◽

pp. 3599-3606 ◽

Cited By ~ 21

Author(s):

Toshiki Mutai ◽

Tatsuya Ohkawa ◽

Hideaki Shono ◽

Koji Araki

Keyword(s):

Excited State ◽

Solid State ◽

Proton Transfer ◽

Intramolecular Proton Transfer ◽

Aryl Group ◽

Red Emission ◽

Wide Range

The color of ESIPT luminescence of HPIP is tuned in a wide range by the introduction of aryl group(s), and thus a series of PIPs showing blue to red emission is realized.

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Total syntheses of (±)-musellarins A–C

Chemical Communications ◽

10.1039/c4cc05248j ◽

2014 ◽

Vol 50 (75) ◽

pp. 10990-10993 ◽

Cited By ~ 12

Author(s):

Zhilong Li ◽

Tsz-Fai Leung ◽

Rongbiao Tong

Keyword(s):

Heck Coupling ◽

Aryl Group ◽

Total Syntheses

The first, diastereoselective total syntheses of musellarins A–C were achieved concisely with 7.8–9.8% yields in 15–16 steps, featuring (i) Achmatowicz rearrangement, Kishi reduction, and Friedel–Crafts cyclization to construct the tricyclic framework and (ii) Heck coupling of aryldiazonium salts to introduce the aryl group into the dihydropyran in a 2,6-trans fashion.

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