γ-Aminobutyric acid (GABA) metabolism in CO2 treated tomatoes

2010 ◽  
Vol 57 (2) ◽  
pp. 97-105 ◽  
Author(s):  
Rujira Deewatthanawong ◽  
Peter Rowell ◽  
Christopher B. Watkins
Keyword(s):  
Aminobutyric Acid ◽  
Gaba Metabolism

scholarly journals THE METABOLISM OF GAMMA AMINOBUTYRIC ACID IN THE LOBSTER NERVOUS SYSTEM

1970 ◽  
Vol 46 (2) ◽  
pp. 290-299 ◽  
Author(s):  
Z. W. Hall ◽  
M. D. Bownds ◽  
E. A. Kravitz
Keyword(s):  
Aminobutyric Acid ◽  
Inhibitory Neurons ◽  
Decarboxylase Activity ◽  
Succinic Semialdehyde ◽  
Gamma Aminobutyric Acid ◽  
Succinic Semialdehyde Dehydrogenase ◽  
Gaba Metabolism ◽  
Semialdehyde Dehydrogenase ◽  
Electrophoretic Behavior ◽  
Inhibitory Transmitter

γ-aminobutyric acid (GABA) is the inhibitory transmitter compound at the lobster neuromuscular junction. This paper presents a comparison of the enzymes of GABA metabolism in single identified inhibitory and excitatory axons from lobster walking legs. Inhibitory axons contain more than 100 times as much glutamic decarboxylase activity as do excitatory axons. GABA-glutamic transaminase is found in both excitatory and inhibitory axons, but about 50% more enzyme is present in inhibitory axons. The kinetic and electrophoretic behavior of the transaminase activity in excitatory and inhibitory axons is similar. Succinic semialdehyde dehydrogenase is found in both axon types, as is an unknown enzyme which converts a contaminant in radioactive glutamic acid to GABA. In lobster inhibitory neurons, therefore, the ability to accumulate GABA ultimately rests on the ability of the neuron to accumulate the enzyme glutamic decarboxylase.

scholarly journals GABA Transaminase Deficiency With Survival Into Adulthood

2019 ◽  
Vol 34 (4) ◽  
pp. 216-220 ◽  
Author(s):  
Anaita U. Hegde ◽  
Purva K. Karnavat ◽  
R. Vyas ◽  
Melissa L. DiBacco ◽  
P. Ellen Grant ◽  
...  
Keyword(s):  
Early Childhood ◽  
Movement Disorder ◽  
Early Onset ◽  
Intractable Epilepsy ◽  
Epileptic Encephalopathy ◽  
Rare Disorder ◽  
Aminobutyric Acid ◽  
Gaba Transaminase ◽  
Gaba Metabolism ◽  
Developmental Impairment

γ-Aminobutyric acid (GABA)-transaminase deficiency is an ultra-rare disorder of GABA metabolism that was described for decades as an early-onset epileptic encephalopathy plus movement disorder and hypersomnolence with mortality in early childhood. We report 2 affected siblings in adolescence and adulthood, both with profound developmental impairment, intractable epilepsy, movement disorder, and behavioral fluctuations. This considerably expands the phenotype and longevity of this inherited neurotransmitter disease.

Gamma-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues

1995 ◽  
Vol 112 (2) ◽  
pp. 247-263 ◽  
Author(s):  
Niranjala J.K. Tillakaratne ◽  
Lali Medina-Kauwe ◽  
K.Michael Gibson
Keyword(s):  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Gaba Metabolism

scholarly journals Effect of “Jian-Pi-Zhi-Dong Decoction” on Gamma-Aminobutyric Acid in a Mouse Model of Tourette Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Wen Zhang ◽  
Wenjing Yu ◽  
Daohan Wang ◽  
Li Wei ◽  
Minkyoung Lee ◽  
...  
Keyword(s):  
Mouse Model ◽  
Mrna Expression ◽  
Tourette Syndrome ◽  
Real Time Pcr ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Mice Model ◽  
Positive Effects ◽  
Gaba Metabolism ◽  
Abnormal Behaviors

The purpose of this study was to explore the positive effects of Jian-Pi-Zhi-Dong Decoction (JPZDD) on Tourette syndrome (TS) by investigating the expression of gamma-aminobutyric acid (GABA) and its type A receptor (GABAAR) in the striatum of a TS mice model. The model was induced by 3,3′-iminodipropionitrile (IDPN) treatment; then mice were divided into 4 groups (n=22, each); control and IDPN groups were gavaged with saline and the remaining 2 groups were gavaged with tiapride and JPZDD. We recorded the stereotypic behaviors of TS mice and measured the content of GABA in striatum by HPLC and GABAAR expression by immunohistochemistry and real-time PCR. Our results showed that JPZDD inhibited the abnormal behaviors of TS model mice and decreased GABA levels and GABAAR protein and mRNA expression in the striatum of TS model mice. In brief, the mechanism by which JPZDD alleviates TS symptoms may be associated with GABAAR expression downregulation in striatum which may regulate GABA metabolism.

and effects on brain GABA metabolism of (S)-4-amino-5-fluoropentanoic acid, a mechanism-based inactivator of γ-aminobutyric acid transaminase

Life Sciences ◽  
1983 ◽  
Vol 32 (24) ◽  
pp. 2717-2723 ◽  
Author(s):  
Richard B. Silverman ◽  
A. Jabbar Muztar ◽  
Mark A. Levy ◽  
James D. Hirsch
Keyword(s):  
Aminobutyric Acid ◽  
Gaba Metabolism ◽  
Brain Gaba
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