Omega-3 fatty acids and cytochrome P450-derived eicosanoids in cardiovascular diseases: Which actions and interactions modulate hemodynamics?

In the last years, Mexico has experimented changes in the epidemiological and nutritional transition. There is a decrease of communicable diseases and an increase of chronic diseases, becoming the main causes of death, mainly cardiovascular diseases. Experimental, epidemiological and interventional studies have demonstrated the beneficial cardiovascular effects of eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA), which have antiatherosclerotic, antithrombotic, antiarrhythmic and anti-inflammatory effects. The American Dietetic Association recommend an ingestion of 250 to 1000 mg/day of omega 3. This paper mentions the functional characteristics, biosynthesis and mechanisms of omega-3 fatty acids. This paper also reviews the clinical evidence that support their role as a cardioprotective factor. Derived from the analysis of the reviewed studies, it is concluded that taking into account the benefits of omega-3 fatty acids in the prevention and treatment of cardiovascular diseases, it is necessary to increase the consumption of foods rich in these fatty acids.

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Faculty Opinions recommendation of Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727733757.793533488 ◽

2017 ◽

Author(s):

J David Spence

Keyword(s):

Fatty Acids ◽

Cardiovascular Diseases ◽

Controlled Trial ◽

B Vitamins ◽

Omega 3 Fatty Acids ◽

Omega 3

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The Possible Effect of Omega 3 Fatty Acids Against Cardiovascular Diseases in Rats: Biochemical and Histopathological Studies

Alexandria Journal of Veterinary Sciences ◽

10.5455/ajvs.55680 ◽

2019 ◽

Vol 62 (1) ◽

pp. 130

Author(s):

Nada Sallai ◽

Mohamed Adl ◽

Gehad Sayed

Keyword(s):

Fatty Acids ◽

Cardiovascular Diseases ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Histopathological Studies

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The Mediterranean-style diet for the prevention of cardiovascular diseases

Public Health Nutrition ◽

10.1079/phn2005933 ◽

2006 ◽

Vol 9 (1a) ◽

pp. 118-123 ◽

Cited By ~ 90

Author(s):

Michel de Lorgeril ◽

Patricia Salen

Keyword(s):

Fatty Acids ◽

Cardiovascular Diseases ◽

Mediterranean Diet ◽

Cardiac Death ◽

Current Knowledge ◽

Epidemiological Studies ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Omega 6 ◽

Traditional Mediterranean Diet

AbstractObjectivesTo discuss present knowledge about Mediterranean diet and cardiovascular diseases.DesignReview of existing literature.Setting and ResultsEpidemiological studies as well as randomised dietary trials suggest that Mediterranean diet may be important in relation to the pathogenesis (and prevention) of CHD. For instance, a striking protective effect of an ALA-rich Mediterranean diet was reported in the Lyon Diet Heart Study with a 50 to 70% reduction of the risk of recurrence after 4 years of follow-up in CHD patients. According to our current knowledge, dietary ALA should represent about 0.6 to 1% of total daily energy or about 2 g per day in patients following a Mediterranean diet, whereas the average intake in linoleic acid should not exceed 7 g per day. Supplementation with very-long-chain omega-3 fatty acids (about 1 g per day) in patients following a Mediterranean type of diet was shown to decrease the risk of cardiac death by 30% and of sudden cardiac death by 45% in the GISSI trial.ConclusionsIn the context of a diet rich in oleic acid, poor in saturated fats and low in omega-6 fatty acids (a dietary pattern characterising the traditional Mediterranean diet), even small doses of omega-3 fatty acids (about 1 g EPA + DHA the form of fish oil capsules or 2 g α-linolenic acid in canola oil and margarine) might be very protective. These data underline the importance of the accompanying diet in any dietary strategy using fatty acid complements.

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