Serum levels of glial cell line-derived neurotrophic factor as a biomarker for mood disorders and lithium response

AbstractGlial cell line-derived neurotrophic factor (GDNF) is widely recognized as a survival factor for dopaminergic neurons, but GDNF has also been shown to promote development, differentiation, and protection of other central nervous system neurons and was thought to play an important role in various neuropsychiatric disorders. Severe mood disorders, such as primarily major depressive disorder and bipolar affective disorder, attract particular attention. These psychopathologies are characterized by structural alterations accompanied by the dysregulation of neuroprotective and neurotrophic signaling mechanisms required for the maturation, growth, and survival of neurons and glia. The main objective of this review is to summarize the recent findings and evaluate the potential role of GDNF in the pathogenesis and treatment of mood disorders. Specifically, it describes (1) the implication of GDNF in the mechanism of depression and in the effect of antidepressant drugs and mood stabilizers and (2) the interrelation between GDNF and brain neurotransmitters, playing a key role in the pathogenesis of depression. This review provides converging lines of evidence that (1) brain GDNF contributes to the mechanism underlying depressive disorders and the effect of antidepressants and mood stabilizers and (2) there is a cross-talk between GDNF and neurotransmitters representing a feedback system: GDNF-neurotransmitters and neurotransmitters-GDNF.

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Association between serum levels of glial cell line-derived neurotrophic factor and inattention in adult patients with attention deficits/hyperactivity disorder

Psychiatry Research ◽

10.1016/j.psychres.2020.113674 ◽

2021 ◽

Vol 296 ◽

pp. 113674

Author(s):

Tomihisa Niitsu ◽

Yasunori Oda ◽

Keita Idemoto ◽

Kiyomitsu Ota ◽

Jing Liu ◽

...

Keyword(s):

Cell Line ◽

Glial Cell ◽

Neurotrophic Factor ◽

Serum Levels ◽

Adult Patients ◽

Attention Deficits ◽

Hyperactivity Disorder

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Serum levels of glial cell line‐derived neurotrophic factor and multiple neurotransmitters: In relation to cognitive performance in Parkinson's disease with mild cognitive impairment

International Journal of Geriatric Psychiatry ◽

10.1002/gps.5222 ◽

2019 ◽

Vol 35 (2) ◽

pp. 153-162 ◽

Cited By ~ 3

Author(s):

Yi Liu ◽

Shuyan Tong ◽

Li Ding ◽

Na Liu ◽

Dianshuai Gao

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cell Line ◽

Glial Cell ◽

Cognitive Performance ◽

Neurotrophic Factor ◽

Serum Levels

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Serum levels of BDNF are associated with craving in opiate-dependent patients

Journal of Psychopharmacology ◽

10.1177/0269881111411332 ◽

2011 ◽

Vol 25 (11) ◽

pp. 1480-1484 ◽

Cited By ~ 37

Author(s):

Annemarie Heberlein ◽

Kenneth M Dürsteler-MacFarland ◽

Bernd Lenz ◽

Helge Frieling ◽

Michael Grösch ◽

...

Keyword(s):

Cell Line ◽

Glial Cell ◽

Neurotrophic Factor ◽

Positive Association ◽

Serum Levels ◽

Brain Derived Neurotrophic Factor ◽

Preclinical Study ◽

Healthy Controls ◽

Addictive Behaviour ◽

Study Results

Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are involved in the modulation of addictive behaviour. We investigated alterations in serum levels of BDNF and GDNF in opiate-dependent patients (28 males) who received diacetylmorphine treatment within a structured opiate maintenance programme. BDNF ( T = 2.735, p = 0.009) serum levels were significantly increased in the opiate-dependent patients as compared with healthy controls (21 males), whereas GDNF serum levels ( T = 1.425, p = 0.162) did not differ significantly from GDNF serum levels of the healthy controls. BDNF serum levels were significantly associated with craving for heroin (measured by the Heroin Craving Questionnaire ( r = 0.420, p = 0.029) and by the General Craving Scale ( r = 0.457, p = 0.016), whereas GDNF serum levels were not associated with psychometric dimensions of heroin craving. In conclusion, our results show a positive association between BDNF serum levels and opiate craving in opiate-dependent patients.

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