scholarly journals Serum levels of BDNF are associated with craving in opiate-dependent patients

2011 ◽  
Vol 25 (11) ◽  
pp. 1480-1484 ◽  
Author(s):  
Annemarie Heberlein ◽  
Kenneth M Dürsteler-MacFarland ◽  
Bernd Lenz ◽  
Helge Frieling ◽  
Michael Grösch ◽  
...  
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Positive Association ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Preclinical Study ◽  
Healthy Controls ◽  
Addictive Behaviour ◽  
Study Results

Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are involved in the modulation of addictive behaviour. We investigated alterations in serum levels of BDNF and GDNF in opiate-dependent patients (28 males) who received diacetylmorphine treatment within a structured opiate maintenance programme. BDNF ( T = 2.735, p = 0.009) serum levels were significantly increased in the opiate-dependent patients as compared with healthy controls (21 males), whereas GDNF serum levels ( T = 1.425, p = 0.162) did not differ significantly from GDNF serum levels of the healthy controls. BDNF serum levels were significantly associated with craving for heroin (measured by the Heroin Craving Questionnaire ( r = 0.420, p = 0.029) and by the General Craving Scale ( r = 0.457, p = 0.016), whereas GDNF serum levels were not associated with psychometric dimensions of heroin craving. In conclusion, our results show a positive association between BDNF serum levels and opiate craving in opiate-dependent patients.

Plasma glial cell line-derived neurotrophic factor in patients with major depressive disorder: a preliminary study

2015 ◽  
Vol 28 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Bun-Hee Lee ◽  
Jin-Pyo Hong ◽  
Jung-A Hwang ◽  
Kyoung-Sae Na ◽  
Won-Joong Kim ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Recurrent Episode ◽  
First Episode ◽  
Healthy Controls ◽  
Major Depressive ◽  
Before And After

BackgroundSome clinical studies have reported reduced peripheral glial cell line-derived neurotrophic factor (GDNF) level in elderly patients with major depressive disorder (MDD). We verified whether a reduction in plasma GDNF level was associated with MDD.MethodPlasma GDNF level was measured in 23 healthy control subjects and 23 MDD patients before and after 6 weeks of treatment.ResultsPlasma GDNF level in MDD patients at baseline did not differ from that in healthy controls. Plasma GDNF in MDD patients did not differ significantly from baseline to the end of treatment. GDNF level was significantly lower in recurrent-episode MDD patients than in first-episode patients before and after treatment.ConclusionsOur findings revealed significantly lower plasma GDNF level in recurrent-episode MDD patients, although plasma GDNF levels in MDD patients and healthy controls did not differ significantly. The discrepancy between our study and previous studies might arise from differences in the recurrence of depression or the ages of the MDD patients.

Hydrophobic dipeptide Leu-Ile protects against neuronal death by inducing brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis

2004 ◽  
Vol 78 (2) ◽  
pp. 250-258 ◽  
Author(s):  
Atsumi Nitta ◽  
Hirofumi Nishioka ◽  
Hidefumi Fukumitsu ◽  
Yoshiko Furukawa ◽  
Haruo Sugiura ◽  
...  
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Neuronal Death ◽  
Brain Derived Neurotrophic Factor

Electroconvulsive therapy increases glial cell-line derived neurotrophic factor (GDNF) serum levels in patients with drug-resistant depression

2009 ◽  
Vol 170 (2-3) ◽  
pp. 273-275 ◽  
Author(s):  
Xiaobin Zhang ◽  
Zhijun Zhang ◽  
Weiwei Sha ◽  
Chunming Xie ◽  
Guangjun Xi ◽  
...  
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Electroconvulsive Therapy ◽  
Neurotrophic Factor ◽  
Serum Levels ◽  
Drug Resistant ◽  
Resistant Depression

Association between serum levels of glial cell-line derived neurotrophic factor and attention deficits in schizophrenia

2014 ◽  
Vol 575 ◽  
pp. 37-41 ◽  
Author(s):  
Tomihisa Niitsu ◽  
Yukihiko Shirayama ◽  
Daisuke Matsuzawa ◽  
Eiji Shimizu ◽  
Kenji Hashimoto ◽  
...  
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Serum Levels ◽  
Attention Deficits

scholarly journals The roles of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor and nerve growth factor during the final stage of folliculogenesis: a focus on oocyte maturation

Reproduction ◽  
2013 ◽  
Vol 145 (2) ◽  
pp. R43-R54 ◽  
Author(s):  
Katja Linher-Melville ◽  
Julang Li
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Line ◽  
Glial Cell ◽  
Oocyte Maturation ◽  
Neurotrophic Factor ◽  
Final Stage ◽  
Brain Derived Neurotrophic Factor ◽  
Peripheral Tissues ◽  
Nerve Growth

Neurotrophic factors were first identified to promote the growth, survival or differentiation of neurons and have also been associated with the early stages of ovarian folliculogenesis. More recently, their effects on the final stage of follicular development, including oocyte maturation and early embryonic development, have been reported. Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are expressed in numerous peripheral tissues outside of the CNS, most notably the ovary, are now known to stimulate oocyte maturation in various species, also enhancing developmental competence. The mechanisms that underlie their actions in antral follicles, as well as the targets ultimately controlled by these factors, are beginning to emerge. GDNF, BDNF and NGF, alone or in combination, could be added to the media currently utilized forin vitrooocyte maturation, thereby potentially increasing the production and/or quality of early embryos.

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