Low plasma lactate concentration as a biomarker of an incompetent brain-pull: A risk factor for weight gain in type 2 diabetes patients

Abstract Background : Offspring of diabetes patients have an absolute risk of 20-40% of developing the condition. Diabetes patients should be encouraged to speak to their offspring regarding diabetes risk and prevention strategies. The Health Belief Model conceptualises that the higher the perceived risk, the more likely an individual will modify their behaviour. The objectives of this study were to i) determine the distribution of type 2 diabetes patients regarding their willingness to accept training to speak to their offspring, ii) determine the distribution of type 2 diabetes patients regarding their willingness to accept training based on the HBM and iii) to determine the factors associated with their willingness to accept training. Methods : This was a cross-sectional study amongst type 2 diabetes patients attending two primary care clinics in Malaysia. Sociodemographic data and knowledge of diabetes risk factors were collected. The adapted, translated and validated Diabetes Mellitus in the Offspring Questionnaire-Malay version (DMOQ-Malay) was self-administered. Statistical analysis included descriptive statistics, univariate and multiple logistic regression. Results : A total of 425 participants were recruited. Of these, 61.6% were willing to accept training. In MLogR, six variables were found to be significantly associated with willingness to accept training. These were i) positive family history [Adj. OR 2.06 (95% CI: 1.27, 3.35)], ii) having correct knowledge that being overweight is a risk factor [Adj. OR 1.49 (95%CI: 1.01, 2.29)], iii) correctly identifying age 40 years old as a risk factor [Adj. OR 1.88 (95%CI: 1.22, 2.90)], iv) agreeing that speaking to their offspring would help them to prevent type 2 diabetes [Adj. OR 4.34 (95%: 1.07, 17.73)], v) being neutral with the statement ‘I do not have much contact with my offspring’ [Adj. OR: 0.31 (95% CI: 0.12, 0.810] and vi) being neutral with the statement ‘my offspring are not open to advice from me’ [Adj. OR: 0.63 (95% CI: 0.31, 0.84]. Conclusion : The majority of type 2 diabetes patients were willing to accept training to speak to their offspring to prevent diabetes. A training module should be designed to enhance their knowledge, attitude and skills to become family health educators.

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The Effect Of Diet Composition On Weight Gain in Obese, Type 2 Diabetes Patients Receiving Intensive Insulin Therapy

American Journal of Health Sciences (AJHS) ◽

10.19030/ajhs.v6i2.9579 ◽

2015 ◽

Vol 6 (2) ◽

pp. 111-116

Author(s):

Roland Villareal

Keyword(s):

Type 2 Diabetes ◽

Weight Gain ◽

Insulin Therapy ◽

Intensive Insulin Therapy ◽

Diet Composition ◽

High Carbohydrate ◽

Total Calorie ◽

Mufa Diet ◽

Diabetes Patients

This study was conducted to contribute to the limiting existing body of literature about diet and prevention of weight gain when administering intensive insulin therapy. The effects of a high- monounsaturated fatty acid (MUFA) diet compared with a conventional diabetic diet have not been studied in insulin treated patients. A growing body of evidence assessed that diets rich in high-MUFA foods had similar glycemic results, as do low-fat, high carbohydrate diets. However, a high-MUFA diet did not raise triglycerides as suspected. Ros (2003) stated that high-MUFA energy controlled diets do not promote weight gain and are more acceptable for weight loss and/or maintenance. A MUFA diet can be used as an alternate to the conventional American Diabetic Association (ADA) diet when managing obese type 2 diabetes patients treated with intensive insulin therapy. Dietary restriction to 1600 calories in diabetes patients on intensive insulin therapy decreased the A1C value by 1.3 points in the ADA group and 1.5 points in the MUFA group without weight gain and without additional insulin required. In conclusion the total calorie count was more important for preventing weight gain and reducing the A1C in patients on intensive insulin therapy than was dietary composition.

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Factors Associated With Weight Gain and Hypoglycaemia and The Impact Upon Hospitalisation in Type 2 Diabetes Patients Managed With Metformin Plus Sulphonylurea

Value in Health ◽

10.1016/j.jval.2014.08.783 ◽

2014 ◽

Vol 17 (7) ◽

pp. A360

Author(s):

P. McEwan ◽

J. Gordon ◽

M. Evans ◽

J. Puelles

Keyword(s):

Type 2 Diabetes ◽

Weight Gain ◽

Factors Associated ◽

The Impact ◽

Diabetes Patients

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Less weight gain and hypoglycaemia with once-daily insulin detemir than NPH insulin in intensification of insulin therapy in overweight Type 2 diabetes patients-The PREDICTIVE™ BMI clinical trial1

Diabetic Medicine ◽

10.1111/j.1464-5491.2008.02483.x ◽

2008 ◽

Vol 25 (8) ◽

pp. 916-923 ◽

Cited By ~ 49

Author(s):

C. Fajardo Montañana ◽

C. Hernández Herrero ◽

M. Rivas Fernández

Keyword(s):

Type 2 Diabetes ◽

Weight Gain ◽

Insulin Therapy ◽

Insulin Detemir ◽

Nph Insulin ◽

Once Daily ◽

Daily Insulin ◽

Diabetes Patients

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Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes

Journal of Applied Physiology ◽

10.1152/japplphysiol.00660.2005 ◽

2005 ◽

Vol 99 (5) ◽

pp. 2008-2019 ◽

Cited By ~ 654

Author(s):

Karine Spiegel ◽

Kristen Knutson ◽

Rachel Leproult ◽

Esra Tasali ◽

Eve Van Cauter

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Risk Factor ◽

Weight Gain ◽

Glucose Metabolism ◽

Molecular Mechanisms ◽

Sleep Loss ◽

Obesity And Diabetes ◽

Chronic Sleep

Chronic sleep loss as a consequence of voluntary bedtime restriction is an endemic condition in modern society. Although sleep exerts marked modulatory effects on glucose metabolism, and molecular mechanisms for the interaction between sleeping and feeding have been documented, the potential impact of recurrent sleep curtailment on the risk for diabetes and obesity has only recently been investigated. In laboratory studies of healthy young adults submitted to recurrent partial sleep restriction, marked alterations in glucose metabolism including decreased glucose tolerance and insulin sensitivity have been demonstrated. The neuroendocrine regulation of appetite was also affected as the levels of the anorexigenic hormone leptin were decreased, whereas the levels of the orexigenic factor ghrelin were increased. Importantly, these neuroendocrine abnormalities were correlated with increased hunger and appetite, which may lead to overeating and weight gain. Consistent with these laboratory findings, a growing body of epidemiological evidence supports an association between short sleep duration and the risk for obesity and diabetes. Chronic sleep loss may also be the consequence of pathological conditions such as sleep-disordered breathing. In this increasingly prevalent syndrome, a feedforward cascade of negative events generated by sleep loss, sleep fragmentation, and hypoxia are likely to exacerbate the severity of metabolic disturbances. In conclusion, chronic sleep loss, behavioral or sleep disorder related, may represent a novel risk factor for weight gain, insulin resistance, and Type 2 diabetes.

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