The role of combined modifiable lifestyle behaviors in the association between exposure to stressors and allostatic load: a systematic review of observational studies.

The recent discovery of microRNAs (miRNAs) in human reproductive tissues and cells indicates a possible functional role in reproductive function. However, the studies published to date in female reproductive tissues/cells and embryos are inconclusive and sometimes controversial. In order to update the knowledge of this field, the present study aimed to discuss, through a systematic review, the role of miRNAs in female human reproduction and early embryogenesis. We conducted a systematic review of the published literature in MEDLINE and EMBASE databases through June 2018 (plus a complementary search until July 2019), in accordance with the PRISMA guidelines. We have included descriptive and observational studies, in which fertile/infertile women were well-defined. The primary outcome was the miRNA expression in ovaries, oocytes, extracellular vesicles, and embryos. We identified 25,204 articles, of which 28 were selected for qualitative analysis: 18 in ovaries and extracellular vesicles, three in oocytes, and seven in embryos. The present systematic review of descriptive and observational studies demonstrates that aberrant miRNA expression in female reproductive tissues/cells and embryos is related with infertility and embryogenesis errors. The expression of specific miRNAs, particularly in extracellular vesicles, may be used in the future as biomarkers of infertility and prognostic tools of embryo development.

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Role of observational studies in supporting extrapolation of efficacy data from adults to children with epilepsy — A systematic review of the literature using lacosamide as an example

European Journal of Paediatric Neurology ◽

10.1016/j.ejpn.2019.05.002 ◽

2019 ◽

Vol 23 (4) ◽

pp. 589-603 ◽

Cited By ~ 1

Author(s):

A. Arzimanoglou ◽

L. Kalilani ◽

M.A. Anamoo ◽

M. Cooney ◽

A. Golembesky ◽

...

Keyword(s):

Systematic Review ◽

Observational Studies ◽

Review Of The Literature ◽

Efficacy Data

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Obesity and dental caries: systematic review

Revista de Saúde Pública ◽

10.1590/s0034-8910.2013047004608 ◽

2013 ◽

Vol 47 (4) ◽

pp. 799-812 ◽

Cited By ~ 29

Author(s):

Alexandre Emidio Ribeiro Silva ◽

Ana Maria Baptista Menezes ◽

Flavio Fernando Demarco ◽

Fabiana Vargas-Ferreira ◽

Marco Aurelio Peres

Keyword(s):

Systematic Review ◽

Dental Caries ◽

Observational Studies ◽

Web Of Science ◽

Scientific Evidence ◽

Positive Association ◽

Sufficient Evidence ◽

Inverse Association

OBJECTIVE Identifying, through a systematic literature review, evidence of a possible association between obesity and dental caries. METHODS A search of articles published between 2005 and January 2012 was performed in the Medline/PubMed, LILACS and Web of Science databases. The quality of scientific evidence of the selected articles was assessed by the items proposed for observational studies in the Downs & Black instrument. RESULTS Initially, 537 references were found; after checking the titles and abstracts by two independent researchers, twenty-eight articles were selected for complete reading. Ten of them that assessed the primary and/or permanent dentition observed a positive association between obesity and dental caries and one study found an inverse association. According to the Downs & Black classification, thirteen articles with good scientific evidence were found. CONCLUSIONS The present review did not find sufficient evidence regarding the association between obesity and dental caries, and it did not clarify the possible role of diet and other possible effect modifiers on this association.

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The role of neoadjuvant chemotherapy followed by interval debulking surgery in advanced ovarian cancer: a systematic review and meta-analysis of randomized controlled trials and observational studies

Oncotarget ◽

10.18632/oncotarget.23808 ◽

2017 ◽

Vol 9 (9) ◽

pp. 8614-8628 ◽

Cited By ~ 12

Author(s):

Meng Qin ◽

Ying Jin ◽

Li Ma ◽

Yan-Yan Zhang ◽

Ling-Ya Pan

Keyword(s):

Systematic Review ◽

Ovarian Cancer ◽

Observational Studies ◽

Meta Analysis ◽

Advanced Ovarian Cancer ◽

Controlled Trials ◽

Debulking Surgery ◽

Randomized Controlled ◽

Interval Debulking Surgery

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The Role of NT-proBNP as Prognostic Biomarker for Preeclampsia Complications: A Systematic Review Protocol

10.21203/rs.3.rs-388263/v1 ◽

2021 ◽

Author(s):

Aiman Hilmi Asaduddin ◽

Shafira Yasmine Anshari ◽

Agni Shalha Ali ◽

Ardhia Fefrine Indarta ◽

Muhammad Adrianes Bachnas ◽

...

Keyword(s):

Systematic Review ◽

Cardiovascular Disease ◽

Cardiovascular System ◽

Full Text ◽

Plasma Levels ◽

Observational Studies ◽

Cochrane Library ◽

Test Accuracy ◽

Fetal Complications

Abstract Background There are two central dogmas between the pathophysiology of preeclampsia, the placental origin and the extra-placental origin. Recent findings found that women with a history of preeclampsia are at higher risk of cardiovascular disease and death because of cardiovascular disease. This finding leads to the extra-placental origin. During normal pregnancy, the maternal cardiovascular system undergoes modification. However, hemodynamic and vascular modification are disrupted in women who develop preeclampsia. NT-proBNP is a biomarker that indicates the disruption of the cardiovascular system and can predict the complication of preeclampsia. Based on that information, we would like to investigate the roles of NT-proBNP plasma levels in predicting maternal and fetal complications of preeclampsia women. Besides, we also investigate the roles of NT-proBNP plasma levels in predicting the severity and onset of preeclampsia women and the sensitivity and specificity of NT-proBNP plasma levels in preeclamptic women.MethodsWe designed and registered a study protocol for a systematic review. This study aims to investigate the roles of NT-proBNP plasma levels in predicting maternal and fetal complications of preeclampsia women. The Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy was used to structure our methodological approach and the Preferred Reporting Items for a Systematic Review and Meta-Analysis Protocols guidelines in reporting the findings of this review. We will search literature in Hinari, Cochrane Library, ScienceDirect, and Scopus database. Then, we will search the grey literature in OCLC’s OAISTER. Randomized controlled trials and observational studies will be included in the analysis. Three reviewers will independently screen articles, extract data, and evaluate for quality and bias using Newcastle-Ottawa Scale. Studies were included according to the following procedures: (1) Identification, Duplication of articles and non-original research articles will be excluded; (2) Title and Abstract Screening, RCT and observational studies and focused on NT-proBNP levels in preeclampsia; (3) Full-text availability; and (4) Full-text screening based on PICO criteria. Each outcome is synthesized by a qualitative or narrative approach. The results will be divided into certain points, namely (a) Selection of the studies, (b) Characteristics of the Eligible Studies, (c) Data Extraction of the Eligible Studies, and (d) Risk of Bias Analysis Results.Discussion A systematic review of the role of NT-proBNP as predicting biomarkers for preeclampsia complications will be conducted. This study can help predict the severity, onset, and complication of a pregnant woman with preeclampsia.

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Prevalence and Risk Factors for Spasticity After Stroke: A Systematic Review and Meta-Analysis

Frontiers in Neurology ◽

10.3389/fneur.2020.616097 ◽

2021 ◽

Vol 11 ◽

Author(s):

Huangling Zeng ◽

Jian Chen ◽

Yang Guo ◽

Sheng Tan

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Observational Studies ◽

Hemorrhagic Stroke ◽

Meta Analysis ◽

Cochrane Library ◽

Stroke Patients ◽

Pooled Prevalence ◽

Severe Spasticity

Background: Spasticity is a common sequela of stroke. The incidence of poststroke spasticity (PSS) has not been systematically reviewed in recent years, and some risk factors remain debated. This systematic review and meta-analysis was conducted to determine the prevalence and risk factors for PSS.Methods: We searched electronic databases (PubMed, Embase, Cochrane Library, CNKI, WANFANG and CBM) inception to May 12, 2020. Observational studies summarizing the incidence or risk factors for PSS were included. Only cohort studies were enrolled in meta-analysis. For risk factors examined in at least three different studies, we combined effects into odds ratios (OR) and 95% confidence intervals (CI).Results: One thousand four hundred sixty-seven studies were retrieved and 23 were involved in meta-analysis. The pooled prevalence of spasticity after stroke was 25.3% and that after the first-ever stroke was 26.7%. The incidence of spasticity after the first-ever stroke with paresis was 39.5%. The prevalence of disabling or severe spasticity (MAS ≥ 3) in stroke patients with paresis was 9.4% (95% CI 0.056–0.133), and severe spasticity was 10.3% (95% CI 0.058–0.149). Moderate to severe paresis (OR = 6.573, 95% CI 2.579–16.755, I2 = 0.0%), hemorrhagic stroke (OR = 1.879, 95% CI 1.418–2.490, I2 = 27.3%) and sensory disorder were risk factors for PSS.Conclusions: The incidence of PSS was significantly higher in stroke patients with paresis. Patients with moderate to severe paresis and sensory disorder should be closely followed up. The role of hemorrhagic stroke in predicting PSS remains to be further explored.

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