The relationship between carbon monoxide breathing, tumour oxygenation and local tumour control in the C3H mammary carcinoma in vivo

Background: Rectal cancer (RC) is one of the most commonly diagnosed and particularly challenging tumours to treat due to its location in the pelvis and close proximity to critical genitourinary organs. Radiotherapy (RT) is recognised as a key component of therapeutic strategy to treat RC, promoting the downsizing and downstaging of large RCs in neoadjuvant settings, although its therapeutic effect is limited due to radioresistance. Evidence from experimental and clinical studies indicates that the likelihood of achieving local tumour control by RT depends on the complete eradication of cancer stem cells (CSC), a minority subset of tumour cells with stemness properties. Methods: A systematic literature review was conducted by querying two scientific databases (Pubmed and Scopus). The search was restricted to papers published from 2009 to 2021. Results: After assessing the quality and the risk of bias, a total of 11 studies were selected as they mainly focused on biomarkers predictive of RT-response in CSCs isolated from patients affected by RC. Specifically these studies showed that elevated levels of CD133, CD44, ALDH1, Lgr5 and G9a are associated with RT-resistance and poor prognosis. Conclusions: This review aimed to provide an overview of the current scenario of in vitro and in vivo studies evaluating the biomarkers predictive of RT-response in CSCs derived from RC patients.

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Nuklearmedizin trifft Strahlentherapie

Nuklearmedizin ◽

10.1055/s-0038-1626533 ◽

2010 ◽

Vol 49 (S 01) ◽

pp. S11-S15

Author(s):

C. Schütze ◽

M. Krause ◽

A. Yaromina ◽

D. Zips ◽

M. Baumann

Keyword(s):

Nuclear Medicine ◽

Radiation Oncology ◽

External Beam Radiotherapy ◽

Biological Knowledge ◽

Important Research ◽

Tumour Control ◽

Research Areas ◽

Normal Tissue Damage ◽

Local Tumour Control ◽

Local Tumour

SummaryRadiobiological and cell biological knowledge is increasingly used to further improve local tumour control or to reduce normal tissue damage after radiotherapy. Important research areas are evolving which need to be addressed jointly by nuclear medicine and radiation oncology. For this differences of the biological distribution of diagnostic and therapeutic nuclides compared with the more homogenous dose-distribution of external beam radiotherapy have to be taken into consideration. Examples for interdisciplinary biology-based cancer research in radiation oncology and nuclear medicine include bioimaging of radiobiological parameters characterizing radioresistance, bioimage-guided adaptive radiotherapy, and the combination of radiotherapy with molecular targeted drugs.

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PO-1926 Enhanced local tumour control by combining proton radiation and immunotherapy

Radiotherapy and Oncology ◽

10.1016/s0167-8140(21)08377-8 ◽

2021 ◽

Vol 161 ◽

pp. S1642

Author(s):

M. Horsman ◽

S. Nielsen ◽

M. Sitarz ◽

M. Høyer ◽

B. Sørensen

Keyword(s):

Proton Radiation ◽

Tumour Control ◽

Local Tumour Control ◽

Local Tumour

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Comparing plaque brachytherapy and proton therapy for choroidal melanoma: a review of the literature

Journal of Radiotherapy in Practice ◽

10.1017/s1460396909990197 ◽

2010 ◽

Vol 9 (1) ◽

pp. 53-61

Author(s):

Jeremy P. Appleton ◽

Peter Bridge

Keyword(s):

Conservative Treatment ◽

Proton Therapy ◽

Normal Tissue ◽

Treatment Options ◽

Choroidal Melanoma ◽

Review Of The Literature ◽

Tumour Control ◽

Local Tumour Control ◽

Local Tumour ◽

Plaque Brachytherapy

AbstractThe aims of conservative treatment in patients with ocular melanoma are globe retention, good visual acuity (VA) and local control. Two well-established radiation conservative treatment options are proton beam radiotherapy and episcleral plaque brachytherapy (EPB). Patients who receive treatment with either of these options will experience some degree of radiation-related ocular complications and poor VA. The purpose of this review of the literature is to establish whether there is a significant clinical difference in normal tissue morbidity and local tumour control between proton therapy and EPB, and whether this difference can justify the purchase and implementation of additional proton therapy facilities. Based on this review, evidence suggested that both treatment options are comparable, and that neither proton therapy nor EPB is clinically superior than the other regarding normal tissue morbidity and local tumour control. This review highlighted the need for further research on a larger scale in order to bridge the gap that is apparent within the literature.

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Extensive systemic metastases from primary central nervous system haemangiopericytoma

BJR|case reports ◽

10.1259/bjrcr.20190081 ◽

2020 ◽

Vol 6 (2) ◽

pp. 20190081

Author(s):

Chi Long Ho ◽

Jeremy JH Lam ◽

Robert Chun Chen

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Fatal Outcome ◽

Imaging Features ◽

Tumour Control ◽

Local Tumour Control ◽

Meningeal Tumour ◽

Local Tumour ◽

The Central Nervous System ◽

Extracranial Metastases

Primary intracranial tumours rarely metastasise outside of the central nervous system (CNS). This report describes a rare case of recurrent meningeal haemangiopericytoma with extensive systemic metastases, which eventually resulted in a fatal outcome. We discuss some prevailing theories as to the rarity of extracranial metastases from primary CNS haemangiopericytoma, and elucidate the epidemiology, imaging features, differential diagnosis, treatment, and prognosis of this unusual but surprisingly aggressive meningeal tumour. Besides aggressive treatment for local tumour control, patients with primary CNS haemangiopericytoma require long-term post-treatment surveillance to detect systemic metastases.

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Residual γH2AX foci predict local tumour control after radiotherapy

Radiotherapy and Oncology ◽

10.1016/j.radonc.2013.06.022 ◽

2013 ◽

Vol 108 (3) ◽

pp. 434-439 ◽

Cited By ~ 27

Author(s):

Ulrike Koch ◽

Katharina Höhne ◽

Cläre von Neubeck ◽

Howard D. Thames ◽

Ala Yaromina ◽

...

Keyword(s):

Tumour Control ◽

Γh2ax Foci ◽

Local Tumour Control ◽

Local Tumour

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Nd:YAG laser in penile diseases. Indications and limits

Urologia Journal ◽

10.1177/039156039606300115 ◽

1996 ◽

Vol 63 (1) ◽

pp. 86-90

Author(s):

E. Dotti ◽

F. Gaboardi ◽

A. Bozzola ◽

T. Zago ◽

L. Galli

Keyword(s):

Nd:Yag Laser ◽

Local Anaesthesia ◽

Penile Cancer ◽

Early Stage ◽

Western World ◽

Tumour Control ◽

Local Tumour Control ◽

Good Cosmetic ◽

Local Tumour ◽

Penile Diseases

— Penile cancer is an uncommon malignancy in the western world (1–2% of all malignancies in males). Traditionally it is treated by penis amputation. Today with laser therapy a new opportunity is offered. 16 patients referred to our Dept. for early stage penile cancer. 2 TIS, 7 T1, 1 T2 penile cancer and 6 with Erythroplasia of Queyrat. Before treatment the patients underwent cold biopsy in order to establish the tumour grading and staging of malignancy. A laser irradiation was performed under local anaesthesia using 25–35 Watt/3 sec in the penile cancer and 15–20 Watt/2 sec in the Erytroplasia of Queyrat. There were no complications after treatment. All patients were observed during follow-up every month after the irradiation until the sixth month and then every 3 months. No-one developed local recurrence or metastatic disease: Nd:YAG laser seems to offer a safe, easy treatment compared to traditional surgery. It can be performed under local, anaesthesia without bleeding, permits good local tumour control, a good cosmetic aspect and, finally full functionality of the penis.

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