scholarly journals Carborane confined nanoparticles for boron neutron capture therapy: Improved stability, blood circulation time and tumor accumulation

2011 ◽  
Vol 71 (7) ◽  
pp. 684-693 ◽  
Author(s):  
Shogo Sumitani ◽  
Motoi Oishi ◽  
Yukio Nagasaki
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Blood Circulation ◽  
Circulation Time ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Improved Stability ◽  
Tumor Accumulation

scholarly journals HGG-05. REGRESSION OF RECURRENT GLIOBLASTOMA AFTER BORON NEUTRON CAPTURE THERAPY AND CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY IN A CHILD

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii345-iii345
Author(s):  
Hsin-Hung Chen ◽  
Yi-Wei Chen
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chimeric Antigen Receptor ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Antigen Receptor ◽  
Neutron Capture Therapy ◽  
T Cell Therapy ◽  
Boron Neutron Capture ◽  
Car T

Abstract A 6 y/o girl with recurrent multifocal glioblastoma received 3 times of boron neutron capture therapy (BNCT) and chimeric antigen receptor (CAR)–engineered T cells targeting the tumor-associated antigen HER2. Multiple infusions of CAR T cells were administered over 30 days through intraventricular delivery routes. It was not associated with any toxic effects of grade 3 or higher. After BNCT and CAR T-cell treatment, regression of all existing intracranial lesions were observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid, but new lesions recurred soon after the treatment. This clinical response continued for 14 months after the initiation of first recurrence.

Study of the upper energy limit of useful epithermal neutrons for Boron Neutron Capture Therapy in different tissues

2021 ◽  
pp. 109490
Author(s):  
Pablo Torres-Sánchez ◽  
Ignacio Porras ◽  
Fernando Arias de Saavedra ◽  
Javier Praena
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Energy Limit ◽  
Boron Neutron Capture ◽  
Epithermal Neutrons ◽  
Different Tissues

scholarly journals Optimization of target, moderator, and collimator in the accelerator-based boron neutron capture therapy system: A Monte Carlo study

2020 ◽  
Author(s):  
Bo-Wi Cheon ◽  
Dohyeon Yoo ◽  
Hyojun Park ◽  
Hyun Cheol Lee ◽  
Wook-Geun Shin ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Monte Carlo Study ◽  
Neutron Capture Therapy ◽  
System A ◽  
Boron Neutron Capture

Nucleophilic radiosynthesis of boron neutron capture therapy-oriented PET probe [18F]FBPA using aryldiboron precursors

2021 ◽  
Author(s):  
Jing He ◽  
Heng Yan ◽  
Yanrong Du ◽  
Yan Ji ◽  
Fei Cai ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

A reliable copper-mediated nucleophilic radiosynthesis of the BNCT-oriented PET probe [18F]FBPA was developed using novel aryldiboron precursors.

scholarly journals Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pablo Torres-Sánchez ◽  
Ignacio Porras ◽  
Nataliya Ramos-Chernenko ◽  
Fernando Arias de Saavedra ◽  
Javier Praena
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Beam Shaping ◽  
Proton Accelerator ◽  
Neutron Capture Therapy ◽  
Beam Shape ◽  
New Era ◽  
Boron Neutron Capture ◽  
Optimal Beam ◽  
Beam Shaping Assembly

AbstractBoron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if a optimized epithermal neutron spectrum is obtained, for which the beam shape assembly is a key ingredient. In this paper we propose an optimal beam shaping assembly suited for an affordable low energy accelerator. The beam obtained with the device proposed accomplishes all the IAEA recommendations for proton energies between 2.0 and 2.1 MeV. In addition, there is an overall improvement of the figures of merit with respect to BNCT facilities and previous proposals of new accelerator-based facilities.

Intracellular distribution of various boron compounds for use in boron neutron capture therapy

1993 ◽  
Vol 45 (1) ◽  
pp. 147-155 ◽  
Author(s):  
Nguyen Tien ◽  
Gordon L. Brownell ◽  
Sylvia A. Holden ◽  
Beverly A. Teicher
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Intracellular Distribution ◽  
Neutron Capture Therapy ◽  
Boron Compounds ◽  
Boron Neutron Capture

Rat brain tumor models to assess the efficacy of boron neutron capture therapy: a critical evaluation

2003 ◽  
Vol 62 (1-2) ◽  
pp. 61-74 ◽  
Author(s):  
Rolf F. Barth ◽  
Weilian Yang ◽  
Jeffrey A. Coderre
Keyword(s):  
Brain Tumor ◽  
Rat Brain ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Critical Evaluation ◽  
Neutron Capture Therapy ◽  
Tumor Models ◽  
Boron Neutron Capture ◽  
Rat Brain Tumor

scholarly journals Pseudoprogression in boron neutron capture therapy for malignant gliomas and meningiomas

2009 ◽  
Vol 11 (4) ◽  
pp. 430-436 ◽  
Author(s):  
Shin-Ichi Miyatake ◽  
Shinji Kawabata ◽  
Naosuke Nonoguchi ◽  
Kunio Yokoyama ◽  
Toshihiko Kuroiwa ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Malignant Gliomas ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture
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