scholarly journals Potential role of hydrogen sulfide in diabetes-impaired angiogenesis and ischemic tissue repair

Redox Biology ◽  
2020 ◽  
Vol 37 ◽  
pp. 101704
Author(s):  
Zhongjian Cheng ◽  
Raj Kishore
Keyword(s):  
Hydrogen Sulfide ◽  
Tissue Repair ◽  
Potential Role ◽  
Ischemic Tissue ◽  
Impaired Angiogenesis

scholarly journals Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases

2020 ◽  
Vol 21 (4) ◽  
pp. 1180 ◽  
Author(s):  
Flavia Sunzini ◽  
Susanna De Stefano ◽  
Maria Sole Chimenti ◽  
Sonia Melino
Keyword(s):  
Hydrogen Sulfide ◽  
Tissue Repair ◽  
Potential Role ◽  
Therapeutic Agent ◽  
Inflammatory Diseases ◽  
Biological Effects ◽  
Tissue Repair And Regeneration ◽  
Immune Mediated ◽  
The Social ◽  
Innate Immunity Cells

The social and economic impact of chronic inflammatory diseases, such as arthritis, explains the growing interest of the research in this field. The antioxidant and anti-inflammatory properties of the endogenous gasotransmitter hydrogen sulfide (H2S) were recently demonstrated in the context of different inflammatory diseases. In particular, H2S is able to suppress the production of pro-inflammatory mediations by lymphocytes and innate immunity cells. Considering these biological effects of H2S, a potential role in the treatment of inflammatory arthritis, such as rheumatoid arthritis (RA), can be postulated. However, despite the growing interest in H2S, more evidence is needed to understand the pathophysiology and the potential of H2S as a therapeutic agent. Within this review, we provide an overview on H2S biological effects, on its role in immune-mediated inflammatory diseases, on H2S releasing drugs, and on systems of tissue repair and regeneration that are currently under investigation for potential therapeutic applications in arthritic diseases.

scholarly journals Phosphodiesterase-5 inhibition and cardioprotection: potential role of hydrogen sulfide

2009 ◽  
Vol 9 (S1) ◽  
Author(s):  
Rakesh C Kukreja ◽  
Vinh Q Chau ◽  
Nicholas N Hoke ◽  
Antonio Abbate ◽  
Amit Varma ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Potential Role ◽  
Phosphodiesterase 5

scholarly journals The Hedgehog Signaling Pathway in Ischemic Tissues

2019 ◽  
Vol 20 (21) ◽  
pp. 5270 ◽  
Author(s):  
Igor Giarretta ◽  
Eleonora Gaetani ◽  
Margherita Bigossi ◽  
Paolo Tondi ◽  
Takayuki Asahara ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Tissue Regeneration ◽  
Hedgehog Signaling ◽  
Potential Role ◽  
Hedgehog Signaling Pathway ◽  
Pathological Conditions ◽  
Ischemic Tissue ◽  
Hh Signaling ◽  
The Brain

Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the involvement of Hh signaling in ischemic tissue regeneration and angiogenesis, with particular attention to the heart, the brain, and the skeletal muscle. Updated information on the potential role of the Hh pathway as a therapeutic target in the ischemic condition is also presented.

scholarly journals The Potential Role of Hydrogen Sulfide in the Regulation of Cerebrovascular Tone

Biomolecules ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1685
Author(s):  
Eleni Dongó ◽  
Levente Kiss
Keyword(s):  
Hydrogen Sulfide ◽  
Potential Role ◽  
Great Majority ◽  
Cerebrovascular Circulation ◽  
Vascular Wall ◽  
Systemic Circulation ◽  
Pleiotropic Effect ◽  
Cerebrovascular Diseases ◽  
Experimental Findings

A better understanding of the regulation of cerebrovascular circulation is of great importance because stroke and other cerebrovascular diseases represent a major concern in healthcare leading to millions of deaths yearly. The circulation of the central nervous system is regulated in a highly complex manner involving many local factors and hydrogen sulfide (H2S) is emerging as one such possible factor. Several lines of evidence support that H2S takes part in the regulation of vascular tone. Examinations using either exogenous treatment with H2S donor molecules or alterations to the enzymes that are endogenously producing this molecule revealed numerous important findings about its physiological and pathophysiological role. The great majority of these studies were performed on vessel segments derived from the systemic circulation but there are important observations made using cerebral vessels as well. The findings of these experimental works indicate that H2S is having a complex, pleiotropic effect on the vascular wall not only in the systemic circulation but in the cerebrovascular region as well. In this review, we summarize the most important experimental findings related to the potential role of H2S in the cerebral circulation.

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