scholarly journals Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases

2020 ◽  
Vol 21 (4) ◽  
pp. 1180 ◽  
Author(s):  
Flavia Sunzini ◽  
Susanna De Stefano ◽  
Maria Sole Chimenti ◽  
Sonia Melino
Keyword(s):  
Hydrogen Sulfide ◽  
Tissue Repair ◽  
Potential Role ◽  
Therapeutic Agent ◽  
Inflammatory Diseases ◽  
Biological Effects ◽  
Tissue Repair And Regeneration ◽  
Immune Mediated ◽  
The Social ◽  
Innate Immunity Cells

The social and economic impact of chronic inflammatory diseases, such as arthritis, explains the growing interest of the research in this field. The antioxidant and anti-inflammatory properties of the endogenous gasotransmitter hydrogen sulfide (H2S) were recently demonstrated in the context of different inflammatory diseases. In particular, H2S is able to suppress the production of pro-inflammatory mediations by lymphocytes and innate immunity cells. Considering these biological effects of H2S, a potential role in the treatment of inflammatory arthritis, such as rheumatoid arthritis (RA), can be postulated. However, despite the growing interest in H2S, more evidence is needed to understand the pathophysiology and the potential of H2S as a therapeutic agent. Within this review, we provide an overview on H2S biological effects, on its role in immune-mediated inflammatory diseases, on H2S releasing drugs, and on systems of tissue repair and regeneration that are currently under investigation for potential therapeutic applications in arthritic diseases.

scholarly journals Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Craig R. Wright ◽  
Alister C. Ward ◽  
Aaron P. Russell
Keyword(s):  
Skeletal Muscle ◽  
Tissue Repair ◽  
Therapeutic Agent ◽  
Strenuous Exercise ◽  
Muscle Repair ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Disease States ◽  
Tissue Repair And Regeneration ◽  
Stimulating Factor

Granulocyte colony-stimulating factor (G-CSF) was originally discovered in the context of hematopoiesis. However, the identification of the G-CSF receptor (G-CSFR) being expressed outside the hematopoietic system has revealed wider roles for G-CSF, particularly in tissue repair and regeneration. Skeletal muscle damage, including that following strenuous exercise, induces an elevation in plasma G-CSF, implicating it as a potential mediator of skeletal muscle repair. This has been supported by preclinical studies and clinical trials investigating G-CSF as a potential therapeutic agent in relevant disease states. This review focuses on the growing literature associated with G-CSF and G-CSFR in skeletal muscle under healthy and disease conditions and highlights the current controversies.

scholarly journals The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

Research ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-31
Author(s):  
Rani Mata ◽  
Yuejun Yao ◽  
Wangbei Cao ◽  
Jie Ding ◽  
Tong Zhou ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Tissue Repair ◽  
Cellular Response ◽  
Inflammatory Diseases ◽  
Inflammatory Microenvironment ◽  
Tissue Microenvironment ◽  
Tissue Repair And Regeneration ◽  
Disease Therapy ◽  
Anti Inflammation ◽  
Inflammatory Tissue

Tissue regeneration is an active multiplex process involving the dynamic inflammatory microenvironment. Under a normal physiological framework, inflammation is necessary for the systematic immunity including tissue repair and regeneration as well as returning to homeostasis. Inflammatory cellular response and metabolic mechanisms play key roles in the well-orchestrated tissue regeneration. If this response is dysregulated, it becomes chronic, which in turn causes progressive fibrosis, improper repair, and autoimmune disorders, ultimately leading to organ failure and death. Therefore, understanding of the complex inflammatory multiple player responses and their cellular metabolisms facilitates the latest insights and brings novel therapeutic methods for early diseases and modern health challenges. This review discusses the recent advances in molecular interactions of immune cells, controlled shift of pro- to anti-inflammation, reparative inflammatory metabolisms in tissue regeneration, controlling of an unfavorable microenvironment, dysregulated inflammatory diseases, and emerging therapeutic strategies including the use of biomaterials, which expand therapeutic views and briefly denote important gaps that are still prevailing.

scholarly journals Drug delivery strategies to control macrophages for tissue repair and regeneration

2016 ◽  
Vol 241 (10) ◽  
pp. 1054-1063 ◽  
Author(s):  
Reham Garash ◽  
Anamika Bajpai ◽  
Brandon M Marcinkiewicz ◽  
Kara L Spiller
Keyword(s):  
Drug Delivery ◽  
Tissue Repair ◽  
Chronic Wounds ◽  
Cellular Therapy ◽  
Inflammatory Diseases ◽  
Macrophage Phenotype ◽  
Tissue Repair And Regeneration ◽  
Complex Process ◽  
Tissue Healing ◽  
Delivery Strategies

Tissue repair and regeneration is a complex process. Our bodies have an excellent capacity to regenerate damaged tissues in many situations. However, tissue healing is impaired in injuries that exceed a critical size or are exacerbated by chronic inflammatory diseases like diabetes. In these instances, biomaterials and drug delivery strategies are often required to facilitate tissue regeneration by providing physical and biochemical cues. Inflammation is the body’s response to injury. It is critical for wound healing and biomaterial integration and vascularization, as long as the timing is well controlled. For example, chronic inflammation is well known to impair healing in chronic wounds. In this review, we highlight the importance of a well-controlled inflammatory response, primarily mediated by macrophages in tissue repair and regeneration and discuss various strategies designed to promote regeneration by controlling macrophage behavior. These strategies include temporally controlled delivery of anti-inflammatory drugs, delivery of macrophages as cellular therapy, controlled release of cytokines that modulate macrophage phenotype, and the design of nanoparticles that exploit the inherent phagocytic behavior of macrophages. A clear outcome of this review is that a deeper understanding of the role and timing of complex macrophage phenotypes or activation states is required to fully harness their abilities with drug delivery strategies.

scholarly journals 4CPS-329 Do patients with immune mediated inflammatory diseases think they know their medication?

2021 ◽  
Author(s):  
A Melgarejo-Ortuño ◽  
RM Romero Jiménez ◽  
E Chamorro De Vega ◽  
A Ais Larisgoitia ◽  
ME Lobato Matilla ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Immune Mediated
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