scholarly journals Peroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape

Redox Biology ◽  
2021 ◽  
pp. 102212
Author(s):  
Barbora Salovska ◽  
Alexandra Kondelova ◽  
Kristyna Pimkova ◽  
Zuzana Liblova ◽  
Miroslav Pribyl ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peroxiredoxin 6

scholarly journals Peroxiredoxin 6 is required for blood vessel integrity in wounded skin

2007 ◽  
Vol 179 (4) ◽  
pp. 747-760 ◽  
Author(s):  
Angelika Kümin ◽  
Matthias Schäfer ◽  
Nikolas Epp ◽  
Philippe Bugnon ◽  
Christiane Born-Berclaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Endothelial Cells ◽  
Ultrastructural Level ◽  
Peroxiredoxin 6 ◽  
Severe Hemorrhage ◽  
Vessel Integrity ◽  
Knockout Animals

Peroxiredoxin 6 (Prdx6) is a cytoprotective enzyme with largely unknown in vivo functions. Here, we use Prdx6 knockout mice to determine its role in UV protection and wound healing. UV-mediated keratinocyte apoptosis is enhanced in Prdx6-deficient mice. Upon skin injury, we observe a severe hemorrhage in the granulation tissue of knockout animals, which correlates with the extent of oxidative stress. At the ultrastructural level endothelial cells appear highly damaged, and their rate of apoptosis is enhanced. Knock-down of Prdx6 in cultured endothelial cells also increases their susceptibility to oxidative stress, thus confirming the sensitivity of this cell type to loss of Prdx6. Wound healing studies in bone marrow chimeric mice demonstrate that Prdx6-deficient inflammatory and endothelial cells contribute to the hemorrhage phenotype. These results provide insight into the cross-talk between hematopoietic and resident cells at the wound site and the role of reactive oxygen species in this interplay.

Peroxiredoxin 6 Gene-Targeted Mice Show Increased Lung Injury with Paraquat-Induced Oxidative Stress

2006 ◽  
Vol 8 (1-2) ◽  
pp. 229-237 ◽  
Author(s):  
Yan Wang ◽  
Sheldon I. Feinstein ◽  
Yefim Manevich ◽  
Ye-Shih Ho ◽  
Aron B. Fisher
Keyword(s):  
Oxidative Stress ◽  
Lung Injury ◽  
Peroxiredoxin 6

scholarly journals Mice with Targeted Mutation of Peroxiredoxin 6 Develop Normally but Are Susceptible to Oxidative Stress

2003 ◽  
Vol 278 (27) ◽  
pp. 25179-25190 ◽  
Author(s):  
Xiaosong Wang ◽  
Shelley A. Phelan ◽  
Kristina Forsman-Semb ◽  
Eric F. Taylor ◽  
Christina Petros ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peroxiredoxin 6 ◽  
Targeted Mutation
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