Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice

2020 ◽  
Vol 96 ◽  
pp. 175-184
Author(s):  
Pavla Dostalova ◽  
Eva Zatecka ◽  
Lukas Ded ◽  
Fatima Elzeinova ◽  
Eliska Valaskova ◽  
...  
Keyword(s):  
Low Dose ◽  
Sperm Quality ◽  
Adult Mice ◽  
Ethylhexyl Phthalate

Toxicokinetics of mono-(2-ethylhexyl) phthalate with low-dose exposure applying fluorescence tracing technique

2021 ◽  
pp. 115814
Author(s):  
Yi-Zhen Yuan ◽  
Chong Ye ◽  
Jia-Hui Sun ◽  
Meng-Yuan Hu ◽  
Shao-Jie Huo ◽  
...  
Keyword(s):  
Low Dose ◽  
Ethylhexyl Phthalate

scholarly journals A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood

2020 ◽  
Vol 319 (3) ◽  
pp. G361-G374 ◽  
Author(s):  
Eloisa Salvo ◽  
Patricia Stokes ◽  
Ciara E. Keogh ◽  
Ingrid Brust-Mascher ◽  
Carly Hennessey ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Early Life ◽  
Low Dose ◽  
Behavioral Deficits ◽  
Colonic Inflammation ◽  
Gut Dysbiosis ◽  
Pediatric Inflammatory Bowel Disease ◽  
Adult Mice ◽  
Inflammatory Bowel

Here we describe long-lasting impacts on the microbiota-gut-brain (MGB) axis following administration of low-dose dextran sodium sulfate (DSS) to weaning mice (P21), including gut dysbiosis, colonic inflammation, and brain/behavioral deficits in adulthood (P56). Early-life DSS leads to acute colonic inflammation, similar to adult mice; however, it results in long-lasting deficits in the MGB axis in adulthood (P56), in contrast to the transient deficits seen in adult DSS. This model highlights the unique features of pediatric inflammatory bowel disease.

Altered behaviour in adult mice exposed to a single low dose of DDT and its fatty acid conjugate as neonates

1990 ◽  
Vol 514 (1) ◽  
pp. 141-142 ◽  
Author(s):  
Per Eriksson ◽  
Trevor Archer ◽  
Anders Fredriksson
Keyword(s):  
Fatty Acid ◽  
Low Dose ◽  
Adult Mice ◽  
Acid Conjugate

scholarly journals Low dose bitter leaf improves sperm quality disrupted in immunosuppressed Wistar rats: An experimental study

2020 ◽  
Author(s):  
Risikat Eniola Kadir ◽  
Abdulmumin Ibrahim ◽  
Balkis Abimbola Ibrahim ◽  
Sadiya Musa Gwadabe ◽  
Rukayat Jaji-Sulaimon ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Sperm Quality ◽  
Hematological Parameters ◽  
Immunosuppressive Agents ◽  
Sperm Parameters ◽  
Male Adult ◽  
Sperm Counts ◽  
Group A ◽  
Group B

Background: Synthetic prednisolone (PRED) is a widely used over-the-counter glucocorticoid. Glucocorticoids have inhibitory effects on the immune system and are often used as immunosuppressive agents. Suppressed immunity may impact fertility via the hypothalamic-pituitary-adrenal axis. Bitter leaf (BL) has been shown to improve sperm parameters, but its effects on immunosuppression-associated infertility have not yet been documented. Objective: To determine the fertility effects of bitter leaf on immunosuppressed Wistar rats. Materials and Methods: A total of 30 male adult Wistar rats were randomly assigned to 6 groups (n = 5/each). Group A served as a control and were given distilled water in addition to normal feeds, group B received 2 mg/kg PRED for 14 days and served as the standard immunosuppressed group, and groups C-F were immunosuppressed as in B but in addition received 50 mg/kg levamisole, low-dose (250 mg/kg) BL, highdose (375 mg/kg) BL, and low-dose BL + levamisole, respectively. The CD4 counts, hematological parameters, and sperm parameters were analyzed and compared. Results: There were significant decreases in sperm motility, progressive motility, morphology, and life/death ratio in the animals given PRED only compared to the controls (p = 0.002, 0.001, 0.001, and 0.01, respectively). These were significantly increased in the treated groups, and animals given levamisole and 250 mg/kg BL showed significantly increased sperm counts compared to the controls (p = 0.04 and p = 0.04, respectively). Conclusion: Low-dose BL (250 mg/kg) restored the sperm parameters altered by prednisolone administration. Key words: Bitter leaf, Immunosuppression, Infertility, Prednisolone, Rats.

scholarly journals Evaluating the protective effects of melatonin on di(2-ethylhexyl) phthalate-induced testicular injury in adult mice

2018 ◽  
Vol 108 ◽  
pp. 515-523 ◽  
Author(s):  
Nosrat Bahrami ◽  
Mehdi Goudarzi ◽  
Azam Hosseinzadeh ◽  
Susan Sabbagh ◽  
Russel J. Reiter ◽  
...  
Keyword(s):  
Protective Effects ◽  
Adult Mice ◽  
Testicular Injury ◽  
Ethylhexyl Phthalate

scholarly journals Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells

2020 ◽  
Vol 11 ◽  
Author(s):  
Jau-Ling Suen ◽  
Tai-Ting Wu ◽  
Yue-Hyuan Li ◽  
Chin-Lai Lee ◽  
Fu-Chen Kuo ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Low Dose ◽  
Epigenetic Modification ◽  
Allergic Diseases ◽  
Underlying Mechanism ◽  
Allergic Response ◽  
Consequent Reduction ◽  
Ifn Γ ◽  
Ligand Stimulation ◽  
Ethylhexyl Phthalate

The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its underlying mechanism remain unknown. This study explored the transgenerational mechanism of DEHP on allergic asthma and dendritic cell (DC) homeostasis through epigenetic modification. In a murine model, ancestral exposure of C57BL/6 mice to low-dose DEHP led to trans-generational promoter hypomethylation of the insulin-like growth factor 2 receptor (Igf2r), concomitant with enhanced Igf2r expression and increased apoptosis prominently in CD8α+ DCs upon ligand stimulation, with consequent reduction in their IL-12 secretion and subsequent T cell-derived IFN-γ, thereby promoting a default Th2-associated pulmonary allergic response. Increased apoptosis was also noted in circulating IGF2Rhigh human DCs. Further, in human placenta, the methylation level at the orthologous IGF2R promoter region was shown to be inversely correlated with the level of maternal DEHP intake. These results support the importance of ancestral phthalate exposure in conferring the trans-generational risk of allergic phenotypes, featuring hypo-methylation of the IGF2R gene and dysregulated DC homeostasis.

scholarly journals Exposure to atrazine during puberty reduces sperm viability, increases weight gain and alters the expression of key metabolic genes in the liver of male mice

2019 ◽  
Vol 31 (5) ◽  
pp. 920 ◽  
Author(s):  
Laura E. Cook ◽  
Bethany J. Finger ◽  
Mark P. Green ◽  
Andrew J. Pask
Keyword(s):  
Drinking Water ◽  
Weight Gain ◽  
Low Dose ◽  
Sperm Quality ◽  
Reproductive Capacity ◽  
Negative Consequences ◽  
Male Mice ◽  
Effect Level ◽  
Liver Gene ◽  
Male Reproductive Health

Atrazine (ATZ) is one of the most widely used herbicides worldwide and is a common contaminant in human drinking water. It disrupts metabolic pathways in plants, and has metabolic and reproductive effects in vertebrates, including humans. Few studies have investigated the effects of exposure to low doses of ATZ, especially during sexual development in males. In this study, we exposed C57BL/6J male mice from weaning for 8 weeks to drinking water containing 0.5mgkg−1 bodyweight (BW) day−1 ATZ, the ‘no observed effect’ level used by the Australian government, or a 10-fold higher dose (5mgkg−1 BW day−1). Mice treated with the low dose of ATZ showed increased total and cumulative weight gain. At 12 weeks of age, there was a significant increase in the percentage of dead spermatozoa in both ATZ-exposed groups, as well as decreased epididymal sperm motility in the low-dose ATZ group. Significant changes in testis and liver gene expression were also observed following ATZ exposure. These data demonstrate that a low dose of ATZ can perturb metabolic and reproductive characteristics in male mice. A chronic reduction in sperm quality and increased weight gain could have negative consequences on the reproductive capacity of males, and further studies should consider the effects of long-term ATZ exposure on male reproductive health.

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