Vitamin D deficiency and lung function decline in healthy individuals: A large longitudinal observation study

2021 ◽  
Vol 182 ◽  
pp. 106395
Author(s):  
Kyung-Min Ahn ◽  
Sun-Sin Kim ◽  
Suh-Young Lee ◽  
So-Hee Lee ◽  
Heung-Woo Park
Keyword(s):  
Vitamin D ◽  
Lung Function ◽  
Vitamin D Deficiency ◽  
Healthy Individuals ◽  
Lung Function Decline ◽  
Observation Study ◽  
Longitudinal Observation

scholarly journals Association of Serum Level of 25-Hydroxy Vitamin D Deficiency and Pulmonary Function in Healthy Individuals

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Maryam Moghaddassi ◽  
Marzieh Pazoki ◽  
Ahmad Salimzadeh ◽  
Tayeb Ramim ◽  
Zahra Alipour
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Pulmonary Function ◽  
Vitamin D Deficiency ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Serum Levels ◽  
Forced Expiratory Volume ◽  
Healthy Individuals ◽  
25 Hydroxy Vitamin D

Background. Besides the extensive regulatory role in growing number of biologic processes, vitamin D has been recently considered essential for lungs function as well as protective against exacerbation of chronic obstructive pulmonary diseases. We assessed the correlation between vitamin D serum levels with pulmonary function in healthy individuals. Methods. In a cross-sectional study, healthy volunteer (n=92) participants underwent the following laboratory procedures: a blood test, a 24-hour urine collection test, and the serum level of 25-hydroxy vitamin D before undergoing spirometry. Linear correlation coefficient was calculated to detect the association between serum level of 25-hydroxy vitamin D and pulmonary volumes. Results. The mean age of participants was 39.95±9.98 years. 48% of participants showed different levels of 25-hydroxy vitamin D deficiency. We recognized a consistent direct positive correlation between serum levels of 25-hydroxy vitamin D and lung function volumes. The coefficient for forced vital capacity, forced expiratory volume in 1 second, forced expiratory flow 25–75%, and forced expiratory volume in 1 second/forced vital capacity ratio were 0.610, 0.509, 0.454, and 0.551, respectively. Conclusions. Our findings suggest correlation between higher serum levels of 25-hydroxy vitamin D and improved pulmonary function. Accordingly, supplemental vitamin D might significantly improve treatment response.

Association Between Severe Vitamin D Deficiency, Lung Function and Asthma Control

2017 ◽  
Vol 53 (4) ◽  
pp. 186-191 ◽  
Author(s):  
Seda Beyhan-Sagmen ◽  
Ozgur Baykan ◽  
Baran Balcan ◽  
Berrin Ceyhan
Keyword(s):  
Vitamin D ◽  
Lung Function ◽  
Vitamin D Deficiency ◽  
Asthma Control ◽  
Severe Vitamin

scholarly journals Vitamin D Deficiency Enhances Non-typeable Haemophilus Influenzae Clearance During Repeated Infections but Worsens Lung Function, Irrespective of Cigarette Smoke Exposure

2021 ◽  
Author(s):  
Jef Serré ◽  
Ajime Tom Tanjeko ◽  
Carolien Mathyssen ◽  
Tobias Heigl ◽  
Dana Paulina Cook ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lung Function ◽  
Vitamin D Deficiency ◽  
Cigarette Smoke ◽  
Vitamin D3 ◽  
Inflammatory Cells ◽  
Cigarette Smoke Exposure ◽  
Copd Patients ◽  
Repeated Infections ◽  
The Impact

Abstract Background: In chronic obstructive pulmonary disease (COPD), exacerbations cause acute inflammatory flare-ups and increase the risk for hospitalization and mortality. Exacerbations are common in all disease stages and are often caused by bacterial infections e.g., non-typeable Heamophilus influenzae (NTHi). Accumulating evidence also associates vitamin D deficiency with the severity of COPD and exacerbation frequency. However, it is still unclear whether vitamin D deficiency when combined with cigarette smoking would worsen and prolong exacerbations caused by repeated infections with the same bacterial strain. Methods: vitamin D sufficient (VDS) and deficient (VDD) mice were exposed to nose-only cigarette smoke (CS) for 14 weeks and oropharyngeally instilled with NTHi at week 6, 10 and 14. Three days after the last instillation, mice were assessed for lung function, remodeling, inflammation and immunity. The impact of VDD and CS on inflammatory cells and immunoglobulin (Ig) production was also assessed in non-infected animals while serum Ig production against NTHi and dsDNA was measured in COPD patients before and 1 year after supplementation with Vitamin D3. Results: VDD enhanced NTHi eradication, independently of CS and complete eradiation was reflected by decreased anti-NTHi Ig’s within the lung. In addition, VDD led to an increase in total lung capacity (TLC), lung compliance (Cchord), MMP12/TIMP1 ratio with a rise in serum Ig titers and anti-dsDNA Ig’s. Interestingly, in non-infected animals, VDD exacerbated the CS-induced anti-NTHi Ig’s, anti-dsDNA Ig’s and inflammatory cells within the lung. In COPD patients, serum Ig production was not affected by vitamin D status but anti-NTHi IgG increased after vitamin D3 supplementation in Vitamin D insufficient patients before treatment. Conclusion: During repeated infections, VDD facilitated NTHi eradication and resolution of local lung inflammation through production of anti-NTHi Ig, independently of CS but it also produced autoantibodies. In COPD patients, vitamin D supplementation might be protective against NTHi infections in vitamin D insufficient patient. Future research is needed to decipher the protective or self-destructive effects of VDD on adaptive immunity.Trail registration: ClinicalTrails, NCT00666367. Registered 23 April 2008, https://www.clinicaltrials.gov/ct2/show/study/NCT00666367

scholarly journals STUDY OF THE SERUM LEVELS OF VITAMIN D AND CALCIUM IONIZED IN THYROID DISORDERS

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Abdulrahman Hefdhallah Amer ◽  
Kaushik Chaudhari ◽  
Riyaben Trivedi ◽  
Riddhi Patel
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Thyroid Function ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Vitamin D Insufficiency ◽  
Thyroid Disorders ◽  
Main Role ◽  
Healthy Individuals

Background Vitamin D deficiency is a global health problem, and its role as an immune modulator has been recently tightened. The main role of vitamin D is to maintain calcium and phosphorus homeostasis, thus maintaining bone health. Recent evidence has shown that vitamin D may play a role in a variety disorders such as endocrine diseases, adrenal diseases, polycystic ovary syndrome and particular type 1 diabetes, type 2 diabetes. We evaluated the association between thyroid disorders (subclinical or overt hypothyroidism and subclinical or overt hyperthyroidism) and serum vitamin D3 level in the Indian population and its association with ionized calcium. Methods The cross-sectional study, included patients who visited Shree Krishna Hospital, Karamsad for thyroid evaluation or follow-up. We conducted this study involving a total of 84 individuals with normal thyroid function, were recorded as control. The cases group included 75 patients with hypothyroidism (overt or subclinical) and 10 patients with hyperthyroidism (overt or subclinical). Serum levels of vitamin D3, thyroid function and calcium ionized were measured in all adult subjects. Deficiency of vitamin D is defined as the level of vitamin D3 in the serum less than 50 nmol/L. Vitamin D insufficiency is defined as serum vitamin D3 level between 50 - 75 nmol/L. Vitamin D sufficiency is defined as serum Vit D3 level >75 nmol/L. Result The prevalence of vitamin D deficiency in subclinical and clinical hypothyroidism cases (36 of 40, 90%) was significantly higher than that observed in healthy individuals (0 of 40, 0%). The prevalence of vitamin D deficiency in subclinical and clinical hyperthyroidism cases (4 of 40, 10%). The prevalence of vitamin D insufficiency in subclinical and clinical hypothyroidism cases (24 of 62, 38.7%) was significantly lower than that observed in healthy individuals (controls) (35 of 62, 56.5%).The prevalence of vitamin D insufficiency in subclinical and clinical hyperthyroidism cases (3 of 62, 4.8%).  The prevalence of vitamin D sufficiency in subclinical and clinical hypothyroidism cases (15 of 67, 22.4%) was significantly lower than that observed in healthy individuals (controls) (49 of 67, 73.1 %). The prevalence of vitamin D sufficiency in subclinical and clinical hyperthyroidism cases (3 of 67, 4.5%). Conclusion Vitamin D deficiency was associated with hypothyroidism especially clinical hypothyroidism. Low serum levels of vitamin D3 were associated with high serum TSH levels. Keyword: Vitamin D3, calcium ionized, hypothyroidism and hyperthyroidism.

scholarly journals Vitamin D Deficiency in Children With Vasovagal Syncope Is Associated With Impaired Circadian Rhythm of Blood Pressure

2021 ◽  
Vol 15 ◽  
Author(s):  
Runmei Zou ◽  
Shuo Wang ◽  
Hong Cai ◽  
Fang Li ◽  
Ping Lin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Circadian Rhythm ◽  
Vitamin D Deficiency ◽  
Pediatric Patients ◽  
Vasovagal Syncope ◽  
Serum Vitamin ◽  
Healthy Individuals ◽  
Serum Vitamin D ◽  
Vitamin D Levels

BackgroundVitamin D deficiency is associated with the risk of cardiovascular diseases. We aimed to investigate the serum vitamin D levels in children with vasovagal syncope (VVS) and explore the correlation of vitamin D status and circadian rhythm of blood pressure in VVS pediatric patients.MethodsThis was a retrospective study. 130 syncopal children diagnosed with VVS were included in the study. 110 age and gender matched healthy individuals were enrolled as control. According to serum 25(OH)D levels, VVS patients were divided into vitamin D sufficient group and vitamin D deficient group. Detailed information of VVS children with vitamin D deficiency and sufficiency on demographic data, baseline laboratory testing, echocardiogram, ambulatory blood pressure monitoring, and Holter ECG recording were extracted and analyzed.ResultsVVS children had a higher prevalence of vitamin D deficiency compared with healthy individuals (33.8% vs. 20.0%, P = 0.017). VVS patients with vitamin D deficiency had a higher rate of non-dipper blood pressure (79.5% vs. 59.3%, P = 0.021) and a lower value of square root of mean squared differences of successive normal to normal intervals (rMSSD) (median 107.8 vs. 141.0 ms, P = 0.035) compared with those with vitamin D sufficiency. Logistic regression analysis showed that non-dipper blood pressure was associated with serum 25(OH)D level [OR = 0.979, 95% CI (0.960, 0.999), P = 0.036].ConclusionVVS pediatric patients had a higher prevalence of vitamin D deficiency. VVS children with vitamin D deficiency showed a higher rate of non-dipper blood pressure, suggesting that vitamin D deficiency is correlated with impaired circadian rhythm of blood pressure.

scholarly journals Vitamin D level, lipid profile, and vitamin D receptor and transporter gene variants in sickle cell disease patients from Kurdistan of Iraq

2021 ◽  
Author(s):  
Abdalla Hussein Hama ◽  
Ebrahim Shakiba ◽  
Zohreh Rahimi ◽  
Mehran Karimi ◽  
Hadi Mozafari ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sickle Cell Disease ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Vitamin D Deficiency ◽  
Sickle Cell ◽  
Healthy Individuals ◽  
Cell Disease ◽  
Mineral Density ◽  
Significant Difference

Abstract Background. Sickle cell disease patients are susceptible to the development of vitamin D deficiency. Vitamin D through binding to vitamin receptor (VDR) exerts its function and affects gene transcription in target tissues. Also, VDR variants could affect bone mineral density. Methods. In a case-control study 101 sickle cell disease patients including 61 SS, 39 S/β-thalassemia, and 1 SD along with 110 healthy individuals from Kurdistan of Iraq were studied. The lipid profile, vitamin D level, FokI, and TaqI variants of VDR and group-specific component (GC) were detected using the standard enzymatic method, the immunodiagnostic systems limited EIA kit and PCR-RFLP methods, respectively. Results. Around 93 and 82% SS and S/β thalassemia patients, respectively had vitamin D deficiency compared to 83% healthy individuals. Severe vitamin D deficiency (<10 ng/ml) was detected in 78.7% of SS patients. Plasma levels of total cholesterol, HDL-C, and LDL-C in SCD patients were significantly lower compared to controls. Vitamin D levels were negatively correlated to TG and positively correlated to total cholesterol and HDL-C. The frequencies of the C allele of FokI were 81.7 (p=0.003), 80.2 (p=0.034), and 84.6% (p=0.011) in all SCD, SS, and SS/βthal patients, respectively compared to 69.1% in controls. However, no significant difference was detected by comparing the frequencies of VDR TaqI and GC polymorphisms between SCD patients and controls.Conclusion. In the present study we found hypocholesterolemia, high prevalence of VDR FokI C allele, and low vitamin D level among children and adults with SCD patients from Kurdistan of Iraq.

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