scholarly journals Hepatoprotective and antioxidant activity of aerial parts of Moringa oleifera in prevention of non-alcoholic fatty liver disease in Wistar rats

2020 ◽  
Vol 129 ◽  
pp. 82-90 ◽  
Author(s):  
A. Asgari-Kafrani ◽  
M. Fazilati ◽  
H. Nazem
Keyword(s):  
Antioxidant Activity ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Wistar Rats ◽  
Moringa Oleifera ◽  
Alcoholic Fatty Liver ◽  
Aerial Parts ◽  
Alcoholic Fatty Liver Disease

scholarly journals The Effect of Rat Strain, Diet Composition and Feeding Period on the Development of a Nutritional Model of Non-Alcoholic Fatty Liver Disease in Rats

2011 ◽  
pp. 317-328 ◽  
Author(s):  
O. KUČERA ◽  
T. GARNOL ◽  
H. LOTKOVÁ ◽  
P. STAŇKOVÁ ◽  
Y. MAZUROVÁ ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Wistar Rats ◽  
Male Rats ◽  
Standard Diet ◽  
Sprague Dawley ◽  
Alcoholic Fatty Liver ◽  
Sprague Dawley Rats ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is an important cause of liver-related morbidity and mortality. The aim of this work was to establish and characterize a nutritional model of NAFLD in rats. Wistar or Sprague-Dawley male rats were fed ad libitum a standard diet (ST-1, 10 % kcal fat), a medium-fat gelled diet (MFGD, 35 % kcal fat) and a high-fat gelled diet (HFGD, 71 % kcal fat) for 3 or 6 weeks. We examined the serum biochemistry, the hepatic malondialdehyde, reduced glutathione (GSH) and cytokine concentration, the respiration of liver mitochondria, the expression of uncoupling protein-2 (UCP-2) mRNA in the liver and histopathological samples. Feeding with MFGD and HFGD in Wistar rats or HFGD in Sprague-Dawley rats induced small-droplet or mixed steatosis without focal inflammation or necrosis. Compared to the standard diet, there were no significant differences in serum biochemical parameters, except lower concentrations of triacylglycerols in HFGD and MFGD groups. Liver GSH was decreased in rats fed HFGD for 3 weeks in comparison with ST-1. Higher hepatic malondialdehyde was found in both strains of rats fed HFGD for 6 weeks and in Sprague-Dawley groups using MFGD or HFGD for 3 weeks vs. the standard diet. Expression of UCP-2 mRNA was increased in Wistar rats fed MFGD and HFGD for 6 weeks and in Sprague-Dawley rats using HFGD for 6 weeks compared to ST-1. The present study showed that male Wistar and Sprague-Dawley rats fed by HFGD developed comparable simple steatosis without signs of progression to non-alcoholic steatohepatitis under our experimental conditions.

Histological Effects of Aqueous Extract of Moringa oleifera on the Liver Tissues of Wistar rats fed with High Fat Diet

2017 ◽  
Vol 2 (2) ◽  
pp. 1
Author(s):  
Obayuwana E, Obayuwana E, Ubehenin A.E, Innih S.O, Iwee R, Eidaghese E.C
Keyword(s):  
Body Weight ◽  
Liver Disease ◽  
Fatty Liver ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Moringa Oleifera ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Moringa oleifera belongs to family of moringaceae and is considered as one of the world’s most useful trees, as almost every part of the plant can be used for either as food, or therapeutic purposes. Fatty diet is a significant factor in the pathogenesis of non-alcoholic fatty Liver disease (NAFLD). The study was designed to examine histological effects of aqueous extract of Moringa oleifera on the liver tissues of wistar rat fed with high fat diet. Twenty five adult rats were divided into five groups of five animals each .While group A received distilled water daily only, groups Band C received aqueous extract of Moringa oleifera at doses of 200 mg/kg body weight and fat high diet (30% w/w of the total mash feed) respectively for a duration of seventy days. Others (groups D and E) received aqueous extract of Moringa oleifera at doses of 200 mg/kg body weight and fat high diet for a duration of seventy days. Histology of the liver of the rats fed with high fat diet exhibited significant changes in the architecture of liver tissue. The changes include micro and macro vascular steatosis, increased fatty infiltration, inflammation, sinusoidal dilation, degeneration of veins and vacuolization as compared to normal liver histology. Treatment with 200 mg/kg extract of Moringa oleifera significantly attenuated these effects imposed by high fat diet as compared to the control group. Therefore demonstrated that daily administration of Moringa oleifera leaves extract to rats for a period of 70 days may reverse the formation of hepatic steatosis in non-alcoholic fatty liver disease.

scholarly journals Therapeutic potential of policosanol in the concurrent management of dyslipidemia and non-alcoholic fatty liver disease

2022 ◽  
Vol 8 (1) ◽  
Author(s):  
Mandeep K. Arora ◽  
Sudhanshu Pandey ◽  
Ritu Tomar ◽  
Jagannath Sahoo ◽  
Dinesh Kumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Wistar Rats ◽  
Therapeutic Potential ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Alcoholic Fatty Liver ◽  
Hepatic Oxidative Stress ◽  
Alcoholic Fatty Liver Disease

Abstract Background High-fat diet (HFD) possesses a major cause of cardiovascular disease, and hepatosteatosis. Unfortunately, long-term use of statins has a theoretical possibility of worsening of hepatic histology in the patients with non-alcoholic fatty liver disease (NAFLD). The objective of the study was to explore hepatoprotective potential of policosanol as an alternative to statins in experimental NAFLD. For the same, young male Wistar rats were fed with HFD for 8 weeks to induce NAFLD. 48 adult Wistar rats were distributed into six investigational groups: normal control, HFD control, and four treatment groups, receiving policosanol (50 and 100 mg/kg/day), atorvastatin (30 mg/kg/day), and silymarin (100 mg/kg/day) for 8 weeks along with HFD. Result HFD consumption caused profound hepatotoxicity evident by hepatic oxidative stress, increased Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), Alkaline phosphatase (ALP), and bilirubin content. Treatment with policosanol (100 mg/kg) markedly reduced the elevated SGOT, SGPT, and ALP levels in HFD-fed rats. Moreover, policosanol significantly reduced hepatic oxidative stress manifest by reduced malondialdehyde (MDA) and increased glutathione (GSH) level. The treatment with policosanol (100 mg/kg) was found to be more active in attenuating the HFD-induced hepatotoxicity as compared to policosanol (50 mg/kg) and atorvastatin (30 mg/kg). Moreover, we observed that the hepatoprotective potential of policosanol was comparable to the silymarin. Conclusions The results of the study clearly indicated that the policosanol could be considered an intriguing approach for the treatment of NAFLD.

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