Protective effects of Carica papaya leaf against skin photodamage by blocking production of matrix metalloproteinases and collagen degradation in UVB-irradiated normal human dermal fibroblasts

Inonotus obliquus, which is parasitic on birch and other trees, is a fungus in the family Hymenochaetaceae. In this study, we investigated whether Inonotus obliquus extracts used in traditional medicine were decreased in the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts. As shown in our results, extracts of Inonotus obliquus decreased MMP1 expression in oxidative stress-exposed normal human dermal fibroblasts. Additionally, Inonotus obliquus extracts decreased AP-1 transcriptional activity and phospho-JNK in oxidative stress-exposed normal human dermal fibroblasts. Oxidative stress mediated the elevation of MMP1 mRNA expression and was well regulated by the JNK-AP-1 axis. Therefore, the results suggest that Inonotus obliquus extracts decreased MMP1 mRNA expression by regulating JNK-AP-1 axis. Additionally, Inonotus obliquus extracts have the potential to reduce collagen destruction and the formation of wrinkles and to be used as a cosmetic ingredient.

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Protective Effects of Indole 3-Acetonitrile-4-Methoxy-2-S-β-d-Glucopyranoside From Nasturtium officinale R. Br. Against Ultraviolet B-Induced Photodamage in Normal Human Dermal Fibroblasts

Natural Product Communications ◽

10.1177/1934578x19872425 ◽

2019 ◽

Vol 14 (8) ◽

pp. 1934578X1987242

Author(s):

Yumin Kim ◽

Kyung Suk Bae

Keyword(s):

Dermal Fibroblasts ◽

Ultraviolet B ◽

Type I ◽

Protective Effects ◽

Human Dermal Fibroblasts ◽

Nasturtium Officinale ◽

Type I Procollagen ◽

Matrix Metalloproteinase 1 ◽

Normal Human ◽

Normal Human Dermal Fibroblasts

Ultraviolet radiation induces skin photoaging, which is associated with the elevation of matrix metalloproteinase-1 (MMP-1) and the decrease of procollagen. Nasturtium officinale plays a well-known role in the treatment of sulfur-containing compounds and their important role in protecting human health. However, their skin protective activity toward UVB-induced photodamage remains unclear. In the present study, we investigated the protective effect of indole 3-acetonitrile-4-methoxy-2- S-β-d-glucopyranoside (IAMG) from N. officinale on UVB-irradiated normal human dermal fibroblasts (NHDF). Our results show that IAMG enhanced NHDF cell migration. The UVB-induced increases in MMP-1 and decrease in type I procollagen were ameliorated by IAMG treatment. Taken together, our data strongly suggest that IAMG from N. officinale could reduce UVB-induced photodamage.

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Altered miRNA expression profiles are involved in the protective effects of troxerutin against ultraviolet B radiation in normal human dermal fibroblasts

International Journal of Molecular Medicine ◽

10.3892/ijmm.2014.1647 ◽

2014 ◽

Vol 33 (4) ◽

pp. 957-963 ◽

Cited By ~ 9

Author(s):

HWA JUN CHA ◽

KWANG SIK LEE ◽

GHANG TAI LEE ◽

KUN KOOK LEE ◽

JIN TAE HONG ◽

...

Keyword(s):

Mirna Expression ◽

Expression Profiles ◽

Dermal Fibroblasts ◽

Ultraviolet B ◽

Protective Effects ◽

Human Dermal Fibroblasts ◽

Ultraviolet B Radiation ◽

Mirna Expression Profiles ◽

Normal Human ◽

Normal Human Dermal Fibroblasts

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Inonotus Obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis

10.20944/preprints202002.0137.v1 ◽

2020 ◽

Author(s):

Young Joo Kim ◽

Hwa Jun Cha

Keyword(s):

Oxidative Stress ◽

Matrix Metalloproteinases ◽

Traditional Medicine ◽

Transcriptional Activity ◽

Dermal Fibroblasts ◽

Human Dermal Fibroblasts ◽

Inonotus Obliquus ◽

Normal Human ◽

Normal Human Dermal Fibroblasts

In present study, the effect of Inonotus Obliquus extracts used in traditional medicine was investigated on the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts. As shown our results, extracts of Inonotus Obliquus decreased MMP1 expression in oxidative stress-exposed normal human dermal fibroblasts. Additionally, Inonotus Obliquus extracts decreased AP-1 transcriptional activity and phospho-JNK in oxidative stress exposed normal human dermal fibroblasts. The results suggest that Inonotus Obliquus extracts decreased MMP1 expression using decreasing AP-1 transcriptional activity and phospho-JNK. Therefore, Inonotus Obliquus extracts has potential to reduce formation of wrinkle and to use as a cosmetic ingredient.

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Protective Effects of C24 Ceramide From the Seeds of Brassica napus L. Against Ultraviolet B-Induced Photoaging in Normal Human Dermal Fibroblasts

Natural Product Communications ◽

10.1177/1934578x19860644 ◽

2019 ◽

Vol 14 (6) ◽

pp. 1934578X1986064

Author(s):

Yu M. Kim ◽

Kyung S. Bae

Keyword(s):

Brassica Napus ◽

Dermal Fibroblasts ◽

Ultraviolet B ◽

Type I ◽

Protective Effects ◽

Human Dermal Fibroblasts ◽

Brassica Napus L ◽

Matrix Metalloproteinase 1 ◽

Normal Human ◽

Normal Human Dermal Fibroblasts

Ultraviolet (UV) radiation induces skin photoaging, which is associated with the elevation of matrix metalloproteinase-1 (MMP-1) and the decrease of collagen. Brassica napus plays a well-known role in the treatment of canola oil through their anti-oxidative and DNA protective properties. However, their skin protective activity toward UVB-induced damage remains unclear. In the present study, we investigated the protective effect of C24 ceramide from B. napus on UVB-irradiated normal human dermal fibroblasts. Our results show that C24 ceramide enhanced NHDFs cell migration. The UVB-induced increase in MMP-1 and decrease in type I procollagen were ameliorated by C24 ceramide treatment. Taken together, our data strongly suggest that C24 ceramide from B. napus could reduce UVB-induced photoaging.

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