CHILDHOOD AND ADOLESCENCE PREDICTORS OF PSYCHOSIS IN THE GENERAL POPULATION -BASED NORTHERN FINLAND 1986 BIRTH COHORT

BackgroundThe association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial.AimsTo examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other potential confounders.MethodThe sample (n = 6534) was composed of the prospective general population-based Northern Finland Birth Cohort of 1986. Information on prodromal symptoms of psychosis and cannabis use was collected using questionnaires at age 15–16 years. Participants were followed up for ICD-10 psychotic disorders until age 30 years using nationwide registers.ResultsThe risk of psychosis was elevated in individuals who had tried cannabis five times or more (hazard ratio, (HR) = 6.5, 95% CI 3.0–13.9). The association remained statistically significant even when adjusted for prodromal symptoms, other substance use and parental psychosis (HR = 3.0, 95% CI 1.1–8.0).ConclusionsAdolescent cannabis use is associated with increased risk of psychosis even after adjustment for baseline prodromal symptoms, parental psychosis and other substance use.Declaration of interestNone.

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Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study

The Lancet Respiratory Medicine ◽

10.1016/s2213-2600(15)00426-9 ◽

2015 ◽

Vol 3 (12) ◽

pp. 933-942 ◽

Cited By ~ 99

Author(s):

Ulrike Gehring ◽

Alet H Wijga ◽

Gerard Hoek ◽

Tom Bellander ◽

Dietrich Berdel ◽

...

Keyword(s):

Air Pollution ◽

Cohort Study ◽

Birth Cohort ◽

Population Based ◽

Birth Cohort Study ◽

Childhood And Adolescence

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Difficulty in making contact with others and social withdrawal as early signs of psychosis in adolescents – the Northern Finland Birth Cohort 1986

European Psychiatry ◽

10.1016/j.eurpsy.2013.11.003 ◽

2014 ◽

Vol 29 (6) ◽

pp. 345-351 ◽

Cited By ~ 8

Author(s):

P. Mäki ◽

S. Koskela ◽

G.K. Murray ◽

T. Nordström ◽

J. Miettunen ◽

...

Keyword(s):

General Population ◽

Mental Disorder ◽

Birth Cohort ◽

Psychotic Disorders ◽

Social Withdrawal ◽

Population Based ◽

Clinical Samples ◽

First Episode ◽

Control Group ◽

Episode Psychosis

AbstractAimSocial withdrawal is among the first signs of the prodromal state of psychosis seen in clinical samples. The aim of this prospective study was to find out whether difficulty in making contact with others and social withdrawal precede first episode psychosis in the young general population.MethodsThe members of the Northern Finland Birth Cohort 1986 (n = 6274) completed the PROD-screen questionnaire in 2001–2002. The Finnish Hospital Discharge Register was used to detect both new psychotic and non-psychotic disorders requiring hospitalisation during 2003–2008.ResultsTwenty-three subjects developed psychosis and 89 developed a non-psychotic mental disorder requiring hospitalisation during the follow-up. Of those who developed psychosis, 35% had reported difficulty or uncertainty in making contact with others and 30% social withdrawal in adolescence. In hospitalised non-psychotic disorder, the corresponding precentages were 10 and 13% and in the control group without hospital-treated mental disorder 9 and 11%. The differences between psychotic and non-psychotic hospitalised subjects (P < 0.01) as well as controls (P < 0.001) were statistically significant regarding difficulty or uncertainty in making contact with others.ConclusionsIn this general population-based sample self-reported difficulty or uncertainty in making contact with others in adolescence preceded psychosis specifically compared to hospitalised non-psychotic mental disorders and controls.

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Schizotypal and affective traits in the offspring of antenatally depressed mothers – Relationship to family history of psychosis in the Northern Finland 1966 Birth Cohort

European Psychiatry ◽

10.1016/j.eurpsy.2016.12.006 ◽

2017 ◽

Vol 42 ◽

pp. 36-43 ◽

Cited By ~ 3

Author(s):

T. Taka-Eilola (née Riekki) ◽

J. Miettunen ◽

P. Mäki

Keyword(s):

General Population ◽

Birth Cohort ◽

Depressed Mood ◽

Familial Risk ◽

Population Based ◽

Adult Offspring ◽

Parental History ◽

Affective Traits ◽

History Of ◽

Depressed Mothers

AbstractBackgroundMaternal depression is relatively common during pregnancy. However, follow-ups of the adult offspring of antenatally depressed mothers are scarce. Previously we found the risk of schizophrenia to be higher in the adult offspring with antenatally depressed mothers and parents with psychosis than in subjects with only one or neither of these risk factors. The aim was to study whether the risk of schizotypal or affective traits differ among adult offspring with antenatally depressed mothers with or without a parental history of psychosis when compared with offspring without antenatally depressed mothers and without parental psychosis.MethodsIn the general population-based Northern Finland 1966 Birth Cohort (NFBC 1966), the mothers of the cohort members were asked at mid-gestation whether they felt depressed. Parental psychosis (Familial Risk, FR) was detected using the Finnish Care Register for Health Care. In the 31-year field study, seven psychometric questionnaires surveyed schizotypal and affective traits in the offspring. The final sample included 4928 individuals (2203 males).ResultsThere were no statistically significant differences in mean scores on the schizotypal and affective scales between offspring with and without antenatally depressed mothers, or between subjects with and without parental psychosis. The scores were not highest in the subjects with both maternal antenatal depressed mood and FR.ConclusionSurprisingly, maternal depressed mood during pregnancy was unlikely to increase the risk of schizotypy or affective traits in adult offspring, and not even with parental psychosis (FR) in this general population-based birth cohort with about 5000 subjects.

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30.3 ASSOCIATION BETWEEN SERUM C-REACTIVE PROTEIN, POSITIVE AND NEGATIVE SYMPTOMS OF PSYCHOSIS IN A GENERAL POPULATION-BASED BIRTH COHORT

Schizophrenia Bulletin ◽

10.1093/schbul/sby014.124 ◽

2018 ◽

Vol 44 (suppl_1) ◽

pp. S48-S49

Author(s):

Golam Khandaker ◽

Jan Stochl ◽

Stanley Zammit ◽

Robert Dantzer ◽

Glyn Lewis ◽

...

Keyword(s):

General Population ◽

Birth Cohort ◽

Negative Symptoms ◽

Population Based ◽

C Reactive Protein ◽

Reactive Protein ◽

Positive And Negative Symptoms

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Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort

BMJ Open ◽

10.1136/bmjopen-2017-019164 ◽

2018 ◽

Vol 8 (1) ◽

pp. e019164

Author(s):

Romina Buffarini ◽

María Clara Restrepo-Méndez ◽

Vera Maria Silveira ◽

Helen D Gonçalves ◽

Isabel O Oliveira ◽

...

Keyword(s):

Cardiovascular Risk ◽

Weight Gain ◽

Birth Cohort ◽

Hdl Cholesterol ◽

Population Based ◽

Childhood And Adolescence ◽

Rapid Weight Gain ◽

Reactive Protein ◽

Height Gain ◽

First Year Of Life

ObjectiveTo evaluate the association between growth trajectories from birth to adolescence and cardiovascular risk marker levels at age 18 years in a population-based cohort. In order to disentangle the effect of weight gain from that of height gain, growth was analysed using conditional weight relative to linear growth (CWh) and conditional length/height (CH).DesignProspective study.Setting1993 Pelotas birth cohort, Southern Brazil.ParticipantsIndividuals who have been followed up from birth to adolescence (at birth, 1, 4, 11, 15 and 18 years).Primary outcome measuresC-reactive protein (CRP), total cholesterol (TC), LDL cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TGL), systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI) and waist circumference (WC).ResultsIn both sexes, greater CWh at 1 year was positively associated with BMI and WC, whereas greater CWh at most age periods in childhood and adolescence predicted higher CRP, TC, LDL-C, TGL, SBP, DBP, BMI and WC levels, as well as lower HDL-C level. Higher CH during infancy and childhood was positively related with SBP in boys and girls, and with BMI and WC only in boys.ConclusionOur study shows that rapid weight gain from 1 year onwards is positively associated with several markers of cardiovascular risk at 18 years. Overall, our results for the first year of life add evidence to the ‘first 1000 days initiative’ suggesting that prevention of excessive weight gain in childhood might be important in reducing subsequent cardiovascular risk.

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