Prognostic analysis for short - and long-term outcomes of newly diagnosed epilepsy

AbstractIn the ENESTnd study, with ≥10 years follow-up in patients with newly diagnosed chronic myeloid leukemia (CML) in chronic phase, nilotinib demonstrated higher cumulative molecular response rates, lower rates of disease progression and CML-related death, and increased eligibility for treatment-free remission (TFR). Cumulative 10-year rates of MMR and MR4.5 were higher with nilotinib (300 mg twice daily [BID], 77.7% and 61.0%, respectively; 400 mg BID, 79.7% and 61.2%, respectively) than with imatinib (400 mg once daily [QD], 62.5% and 39.2%, respectively). Cumulative rates of TFR eligibility at 10 years were higher with nilotinib (300 mg BID, 48.6%; 400 mg BID, 47.3%) vs imatinib (29.7%). Estimated 10-year overall survival rates in nilotinib and imatinib arms were 87.6%, 90.3%, and 88.3%, respectively. Overall frequency of adverse events was similar with nilotinib and imatinib. By 10 years, higher cumulative rates of cardiovascular events were reported with nilotinib (300 mg BID, 16.5%; 400 mg BID, 23.5%) vs imatinib (3.6%), including in Framingham low-risk patients. Overall efficacy and safety results support the use of nilotinib 300 mg BID as frontline therapy for optimal long-term outcomes, especially in patients aiming for TFR. The benefit-risk profile in context of individual treatment goals should be carefully assessed.

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Short- and long-term outcomes of a self-expandable metallic stent versus a transanal decompression tube for pathological stage II and III left-sided obstructive colorectal cancer: a retrospective observational study

Surgery Today ◽

10.1007/s00595-021-02341-2 ◽

2021 ◽

Author(s):

Kentaro Sato ◽

Ken Imaizumi ◽

Hiroyuki Kasajima ◽

Michihiro Kurushima ◽

Minoru Umehara ◽

...

Keyword(s):

Colorectal Cancer ◽

Observational Study ◽

Metallic Stent ◽

Pathological Stage ◽

Long Term Outcomes ◽

Expandable Metallic Stent ◽

Transanal Decompression Tube ◽

Short And Long Term ◽

Decompression Tube

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Delayed surgical resection of primary left‐sided obstructing colon cancer is associated with improved short‐ and long‐term outcomes

Journal of Surgical Oncology ◽

10.1002/jso.26632 ◽

2021 ◽

Author(s):

Marnix A. J. de Roos ◽

Niek Hugen ◽

Eric J. Hazebroek ◽

Ernst J. Spillenaar Bilgen

Keyword(s):

Colon Cancer ◽

Surgical Resection ◽

Long Term Outcomes ◽

Short And Long Term

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An update on vessel preparation in lower limb arterial intervention

CVIR Endovascular ◽

10.1186/s42155-020-00175-6 ◽

2020 ◽

Vol 3 (1) ◽

Author(s):

William Ormiston ◽

Shelagh Dyer-Hartnett ◽

Rukshan Fernando ◽

Andrew Holden

Keyword(s):

Lower Limb ◽

Vessel Wall ◽

Arterial Intervention ◽

Arterial Disease ◽

Long Term Outcomes ◽

Pulsatile Pressure ◽

Short And Long Term ◽

Late Restenosis ◽

Vessel Preparation

Abstract Background Plain balloon angioplasty has traditionally been used to treat lower limb arterial disease but can be limited by significant residual stenosis, vessel recoil, dissection, and by late restenosis. Appropriate vessel preparation may significantly improve short and long-term outcomes. We aim to give an overview of some of the devices currently available, or under investigation, for vessel preparation in the lower limb. Main text Vessel preparation devices include those that remove plaque (atherectomy devices) and those that modify plaque. The four groups of plaque removing atherectomy devices are defined by their plaque removal method: Directional, rotational orbital and excimer laser are categories of devices investigated for plaque modification. Intravascular lithotripsy devices generate sonic pulsatile pressure waves that pass into the vessel wall cracking calcified plaques whilst sparing soft tissue. This enables dilatation of calcified lesions at low pressure by conventional balloons and enables full stent expansion. Other balloon based vessel preparation devices were designed to modify plaque and produce more controlled, lower pressure luminal expansion without major dissections and potentially with less recoil than conventional angioplasty balloons. Scoring balloons have a helical nitinol element attached to the balloon that scores plaque facilitating uniform luminal enlargement. Further specialty balloons have been developed in recent years, including the Chocolate, Phoenix and Serranator balloons. Finally, the temporary Spur self-expanding retrievable nitinol stent has a series of radially aligned spurs that are driven into the vessel wall by post-dilatation, potentially improving drug delivery. Conclusion Lesion specific vessel preparation aims to improve both short and long term outcomes through improved penetration of anti-proliferative drug, maximising luminal gain, reducing the need for stent placement and minimising intimal injury. Some forms of vessel preparation appear to improve short term outcomes; long-term outcomes remain uncertain. An overview of some of the multiple devices available for vessel preparation is presented.

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