Characteristics of pediatric Behçet's disease in Turkey and Israel: A cross-sectional cohort comparison

2020 ◽  
Vol 50 (3) ◽  
pp. 515-520
Author(s):  
Yonatan Butbul Aviel ◽  
Ezgi Deniz Batu ◽  
Betül Sözeri ◽  
Nuray Aktay Ayaz ◽  
Lemor Baba ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Cohort Comparison

Expression levels of miR-21, miR-146b and miR-326 as potential biomarkers in Behcet's disease

2019 ◽  
Vol 13 (16) ◽  
pp. 1339-1348
Author(s):  
Golamreza Jadideslam ◽  
Khalil Ansarin ◽  
Ebrahim Sakhinia ◽  
Zohreh Babaloo ◽  
Alireza Abhari ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Expression Rate ◽  
Eye Involvement

Aim: Behcet's disease (BD) is a vasculitis. Lines of evidence suggest miRNAs as diagnostic and prognostic markers in autoimmune diseases. This study was designed to investigate the potential role of miR-21, miR-146b and miR-326 as biomarkers for diagnosis, predicting organs involvement and measuring BD activity. Patients & methods: In this cross-sectional study, the study groups consisted of 46 BD patients and 70 age- and sex-matched healthy volunteers. The expression rates of three miRNAs were determined by quantitative real-time PCR. Results: Our results demonstrated significantly lower expression of miR-21 and miR-146b and higher expression of miR-326 in BD patients. MiR-21 expression rate in patients with severe eye involvement and miR-326 expression rate in patients with uveitis and severe eye involvement were increased. Conclusion: MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD.

scholarly journals A national cohort study on pediatric Behçet’s disease: cross-sectional data from an Italian registry

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Romina Gallizzi ◽  
Caterina Pidone ◽  
Luca Cantarini ◽  
Martina Finetti ◽  
Marco Cattalini ◽  
...  
Keyword(s):  
Cohort Study ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
National Cohort

scholarly journals Epidemiology and treatment of Behçet’s disease in the USA: insights from the Rheumatology Informatics System for Effectiveness (RISE) Registry with a comparison with other published cohorts from endemic regions

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Nevin Hammam ◽  
Jing Li ◽  
Michael Evans ◽  
Julia L. Kay ◽  
Zara Izadi ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Systemic Vasculitis ◽  
Patient Characteristics ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Endemic Areas ◽  
The U.S

Abstract Background Behçet’s disease (BD), a chronic systemic vasculitis, has distinct geographical and ethnic variation. Data regarding the epidemiology of patients with BD in the U.S. are limited; therefore, we sought to describe BD patient characteristics and medication use in the U.S., and compared them with data from patients from endemic regions. Methods We conducted a cross-sectional study using data from the RISE registry (2014–2018). Patients aged ≥ 18 years with BD were included. Sociodemographic and treatment information was extracted. We compared patients from the RISE registry to data from other published studies of patients with BD from endemic areas. Results One thousand three hundred twenty-three subjects with BD from the RISE registry were included. Mean age was 48.7 ± 16.3 years, female to male ratio was 3.8:1, and 66.7% were White. The most frequently used medications included glucocorticoids (67.6%) and colchicine (55.0%). Infliximab and adalimumab were the most used biologics (14.5% and 14.1%, respectively); 3.2% of patients used apremilast. The RISE registry had more women (79.3%), and patients were older compared to previously published BD studies from endemic areas. Methotrexate and TNFi were more commonly reported in RISE (21.8% and 29.4%) compared to studies from Egypt and Turkey. Colchicine, cyclosporine, and cyclophosphamide were more commonly used in cohorts from Egypt, Turkey, and Iran. Conclusions Findings from the largest BD dataset in the U.S. suggest that BD patients are predominantly female. Further research is needed to explore the reasons for the higher prevalence of BD among women in the U.S. and its possible impact on disease severity and management.

scholarly journals New Insight Into The Features of Behçet's Disease With Gastrointestinal Ulcer : A Cross-Sectional Observational Study

2021 ◽  
Author(s):  
Jing-Fen Ye ◽  
Cheng-Cheng Hou ◽  
Hua-fang Bao ◽  
Jian long Guan
Keyword(s):  
Gastrointestinal Tract ◽  
Observational Study ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Upper Gastrointestinal Tract ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Gastrointestinal Ulcer ◽  
Upper Gastrointestinal

Abstract Background Behcet’s disease (BD) can involve any site of the alimentary canal. There has been research concerning intestinal BD. Nevertheless, the entire digestive tract not yet been studied extensively. Therefore, the purpose of study was to describe the prevalence, location, clinical features and possible risk factors of BD with gastrointestinal tract ulcer.Methods This was a cross-sectional observational study that included 1232 consecutive BD patients who routinely underwent endoscopy upon their wishes. The clinical symptoms, endoscopic findings, and histologic features of BD with gastrointestinal ulcer and negative Helicobacter pylori (Hp) were identified.Result We found that 22.16% (273/1232) Hp-negative BD patients had ulcers of the alimentary tract. At presentation, 61.54% (168/273) patients were asymptomatic. The numbers of BD patients with gastrointestinal ulcers isolated to upper gastrointestinal tract, small bowel, ileocecal region, ascending colon, transverse colon, descending colon, sigmoid colon and rectum were 84, 4, 106, 2, 3, 1, 2 and 8, respectively. The rest involved at least two of these intestinal segments. Only one patient suffered from total gastrointestinal tract involvement. Inflammation was the most common histopathologic feature 77.60% (142/183). The 273 BD patients with gastrointestinal ulcer were at greater risk of having archenteric symptoms (OR = 0.108, P ＜ 0.001), fever (OR = 0.235, P = 0.001) and high CRP level (OR = 0.991, P = 0.019). Uveitis may be a protective factor for gastrointestinal ulcer in patients with BD (OR = 2.480, P = 0.002). Conclusion BD could affect the upper gastrointestinal tract independently. Endoscopy should be conducted in all patients in whom a diagnosis of BD is entertained, especially in patients with higher CRP and fever. While, BD patients with uveitis correlates negatively with gastrointestinal involvement.

scholarly journals The Effectiveness of Intraocular Methotrexate in the Treatment of Posterior Uveitis in Behçet’s Disease Patients Compared to Retrobulbar Steroids Injection

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Hossam El Din Mohamed Khalil ◽  
Heba A. El Gendy ◽  
Hala Ahmed Raafat Youssef ◽  
Hazem Effat Haroun ◽  
Tamer Atef Gheita ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Posterior Uveitis ◽  
Posterior Segment ◽  
Treatment Modalities ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Group A ◽  
Group B

Aim of Work. To evaluate the efficacy of intravitreal methotrexate (MTX) compared to retrobulbar triamcinolone acetonide (TAA), in controlling posterior segment involvement and inducing remissions among Behçet’s disease (BD) patients.Study Design. This is a cross-sectional nonrandomized comparative study.Patients and Methods. 31 adult BD male patients with a mean disease duration of 5.45 years who presented with bilateral posterior segment involvement were included. Each patient received intravitreal injection of 400 μg/0.1 mL (MTX) for the right eye (Group A) and 1 mL of retrobulbar 40 mg/mL TAA for the left eye (Group B).Results. 90% of eyes showed complete improvement of anterior chamber reaction, whereas an improvement in vitreous activity in 77% with no significant differences between both groups (p≤0.1). BCVA improved in 77.4% eyes (Group A) compared to 87.1% (Group B) (p≤0.4). Relapses were noted in 11 eyes (35.5%), in group A, with the mean duration of remission being 19.1 weeks ± 2.13 compared to7.35±2.8in 20 eyes (64.5%) in group B (p≤0.1).Conclusion. No statistical differences were found between both treatment modalities; however, based on clinical observations, intravitreal MTX may ensure better control of inflammatory reaction and may encourage longer remission as compared to retrobulbar TAA in BD patients.

Characteristics of uveitic glaucoma in Turkish patients

2020 ◽  
pp. 112067212095093
Author(s):  
Oya Tekeli ◽  
Ufuk Elgin ◽  
Tamer Takmaz ◽  
Ümit Ekşioğlu ◽  
Zeynep Baş ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Open Angle Glaucoma ◽  
Turkish Population ◽  
Posterior Uveitis ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Uveitic Glaucoma ◽  
Fuchs Heterochromic Cyclitis

Purpose: To evaluate the prevalence of uveitic glaucoma (UG) in the Turkish population and investigate the primary underlying diseases. Methods: This multicenter, cross-sectional, prospective study included patients who presented to the glaucoma units of 10 tertiary ophthalmology departments in Ankara, Turkey from 15th March to 16th May 2015 and fulfilled the criteria of UG. Patients were inspected for age, sex, medical history, best corrected visual acuity, biomicroscopic findings, intraocular pressure values, and visual field results. Results: During the study period, 4604 eyes of 2541 patients with glaucoma were screened and 145 eyes of 104 patients (4.1%) were identified as having UG. One hundred and thirty-four eyes (92.4%) had open-angle glaucoma and 11 eyes (7.6%) had closed-angle glaucoma. The mean patient age was 47 ± 16 (6–90) years. Idiopathic uveitis (54 eyes), Behçet’s disease (26 eyes), Fuchs heterochromic cyclitis (21 eyes), Herpes Simplex virus infectious uveitis (14 eyes), and ankylosing spondylitis (six eyes) were the leading types of uveitis associated with glaucoma. Acute anterior uveitis was the most common type of uveitis diagnosed in 72 patients (105 eyes), whereas 21 patients (27 eyes) had panuveitis, eight patients (nine eyes) had intermediate uveitis, and three patients (four eyes) had posterior uveitis. The need for surgical intervention was 37.2% among all cases and the most common surgery was trabeculectomy in 45 eyes. Conclusion: UG is a vision-threatening complication commonly seen in patients with uveitis. This study demonstrates the epidemiological features and underlying etiologies of UG in the Turkish population. The most common primary causes of UG were Behçet’s disease and Fuchs heterochromic cyclitis.

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