scholarly journals FRI0350 Investigating the link between ischemic heart disease and behcet's disease: a cross-sectional analysis

2017 ◽  
Author(s):  
Y Yavne ◽  
S Tiosano ◽  
A Watad ◽  
D Comaneshter ◽  
AD Cohen ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Ischemic Heart ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

scholarly journals Cardiac Manifestations in Iranian Patients with Behçet’s Disease

2022 ◽  
Author(s):  
Soraya Shadmanfar ◽  
Maryam Masoumi ◽  
Fereydoun Davatchi ◽  
Massoomeh Akhlaghi ◽  
Seyedeh Tahereh Faezi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Cardiac Involvement ◽  
Behçet's Disease ◽  
Ischemic Heart ◽  
Behcet's Disease ◽  
Cardiac Manifestations

Background: Behcet’s disease (BD) is a vasculitis with multisystem and multiorgan involvement. Cardiac involvement in BD is a rare complication with a poor outcome that manifests itself in different forms. In this study, we aimed to investigate cardiac involvement in BD.  Methods: This is a retrospective study based on cardiac manifestations in BD according to the data of the Behçet’s Disease Unit, the Rheumatology Research Center, Tehran University of Medical Sciences, from registered patients from 1975 until June 2017. Cardiac manifestations consisted of pericarditis, myocardiopathy, myocardial infarction, stable ischemic heart disease, endomyocardial fibrosis, thrombosis, and valvular and coronary involvement. All the patients’ baseline and demographic data were recorded in a designed questionnaire. The laboratory workups, imaging, and pathological tests were also performed.      Results: We studied 7650 patients with BD, of whom 51% were male. In the entire study population, 47 patients manifested cardiac involvement: valvular involvement in 6.1%, myocardial infarction in 23.4%, stable ischemic heart disease in 20%, pericarditis in 21.3%, intracardiac thrombosis in 2.1%, coronary aneurysm in 2.1%, heart failure in 12.8%, and dilated cardiomyopathy in 4.3%. Conclusion: The prevalence of cardiac involvement in our patients with BD was 0.6%. A multidisciplinary approach can reduce mortality and morbidity rates. Consequently, we suggest that echocardiography and other cardiac diagnostic tests be routinely considered for early diagnosis and subsequent treatment.

Expression levels of miR-21, miR-146b and miR-326 as potential biomarkers in Behcet's disease

2019 ◽  
Vol 13 (16) ◽  
pp. 1339-1348
Author(s):  
Golamreza Jadideslam ◽  
Khalil Ansarin ◽  
Ebrahim Sakhinia ◽  
Zohreh Babaloo ◽  
Alireza Abhari ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Expression Rate ◽  
Eye Involvement

Aim: Behcet's disease (BD) is a vasculitis. Lines of evidence suggest miRNAs as diagnostic and prognostic markers in autoimmune diseases. This study was designed to investigate the potential role of miR-21, miR-146b and miR-326 as biomarkers for diagnosis, predicting organs involvement and measuring BD activity. Patients & methods: In this cross-sectional study, the study groups consisted of 46 BD patients and 70 age- and sex-matched healthy volunteers. The expression rates of three miRNAs were determined by quantitative real-time PCR. Results: Our results demonstrated significantly lower expression of miR-21 and miR-146b and higher expression of miR-326 in BD patients. MiR-21 expression rate in patients with severe eye involvement and miR-326 expression rate in patients with uveitis and severe eye involvement were increased. Conclusion: MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD.

Characteristics of pediatric Behçet's disease in Turkey and Israel: A cross-sectional cohort comparison

2020 ◽  
Vol 50 (3) ◽  
pp. 515-520
Author(s):  
Yonatan Butbul Aviel ◽  
Ezgi Deniz Batu ◽  
Betül Sözeri ◽  
Nuray Aktay Ayaz ◽  
Lemor Baba ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Cohort Comparison

scholarly journals A national cohort study on pediatric Behçet’s disease: cross-sectional data from an Italian registry

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Romina Gallizzi ◽  
Caterina Pidone ◽  
Luca Cantarini ◽  
Martina Finetti ◽  
Marco Cattalini ◽  
...  
Keyword(s):  
Cohort Study ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
National Cohort

scholarly journals Epidemiology and treatment of Behçet’s disease in the USA: insights from the Rheumatology Informatics System for Effectiveness (RISE) Registry with a comparison with other published cohorts from endemic regions

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Nevin Hammam ◽  
Jing Li ◽  
Michael Evans ◽  
Julia L. Kay ◽  
Zara Izadi ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Systemic Vasculitis ◽  
Patient Characteristics ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Endemic Areas ◽  
The U.S

Abstract Background Behçet’s disease (BD), a chronic systemic vasculitis, has distinct geographical and ethnic variation. Data regarding the epidemiology of patients with BD in the U.S. are limited; therefore, we sought to describe BD patient characteristics and medication use in the U.S., and compared them with data from patients from endemic regions. Methods We conducted a cross-sectional study using data from the RISE registry (2014–2018). Patients aged ≥ 18 years with BD were included. Sociodemographic and treatment information was extracted. We compared patients from the RISE registry to data from other published studies of patients with BD from endemic areas. Results One thousand three hundred twenty-three subjects with BD from the RISE registry were included. Mean age was 48.7 ± 16.3 years, female to male ratio was 3.8:1, and 66.7% were White. The most frequently used medications included glucocorticoids (67.6%) and colchicine (55.0%). Infliximab and adalimumab were the most used biologics (14.5% and 14.1%, respectively); 3.2% of patients used apremilast. The RISE registry had more women (79.3%), and patients were older compared to previously published BD studies from endemic areas. Methotrexate and TNFi were more commonly reported in RISE (21.8% and 29.4%) compared to studies from Egypt and Turkey. Colchicine, cyclosporine, and cyclophosphamide were more commonly used in cohorts from Egypt, Turkey, and Iran. Conclusions Findings from the largest BD dataset in the U.S. suggest that BD patients are predominantly female. Further research is needed to explore the reasons for the higher prevalence of BD among women in the U.S. and its possible impact on disease severity and management.

scholarly journals New Insight Into The Features of Behçet's Disease With Gastrointestinal Ulcer : A Cross-Sectional Observational Study

2021 ◽  
Author(s):  
Jing-Fen Ye ◽  
Cheng-Cheng Hou ◽  
Hua-fang Bao ◽  
Jian long Guan
Keyword(s):  
Gastrointestinal Tract ◽  
Observational Study ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Upper Gastrointestinal Tract ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Gastrointestinal Ulcer ◽  
Upper Gastrointestinal

Abstract Background Behcet’s disease (BD) can involve any site of the alimentary canal. There has been research concerning intestinal BD. Nevertheless, the entire digestive tract not yet been studied extensively. Therefore, the purpose of study was to describe the prevalence, location, clinical features and possible risk factors of BD with gastrointestinal tract ulcer.Methods This was a cross-sectional observational study that included 1232 consecutive BD patients who routinely underwent endoscopy upon their wishes. The clinical symptoms, endoscopic findings, and histologic features of BD with gastrointestinal ulcer and negative Helicobacter pylori (Hp) were identified.Result We found that 22.16% (273/1232) Hp-negative BD patients had ulcers of the alimentary tract. At presentation, 61.54% (168/273) patients were asymptomatic. The numbers of BD patients with gastrointestinal ulcers isolated to upper gastrointestinal tract, small bowel, ileocecal region, ascending colon, transverse colon, descending colon, sigmoid colon and rectum were 84, 4, 106, 2, 3, 1, 2 and 8, respectively. The rest involved at least two of these intestinal segments. Only one patient suffered from total gastrointestinal tract involvement. Inflammation was the most common histopathologic feature 77.60% (142/183). The 273 BD patients with gastrointestinal ulcer were at greater risk of having archenteric symptoms (OR = 0.108, P ＜ 0.001), fever (OR = 0.235, P = 0.001) and high CRP level (OR = 0.991, P = 0.019). Uveitis may be a protective factor for gastrointestinal ulcer in patients with BD (OR = 2.480, P = 0.002). Conclusion BD could affect the upper gastrointestinal tract independently. Endoscopy should be conducted in all patients in whom a diagnosis of BD is entertained, especially in patients with higher CRP and fever. While, BD patients with uveitis correlates negatively with gastrointestinal involvement.

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