Joint and entheseal inflammation in the knee region in spondyloarthritis- reliability and responsiveness of two OMERACT whole-body MRI scores

The aim of the study is to evaluate the effectiveness of short whole-body magnetic resonance imaging (WBMRI) protocols for the overall assessment of bone marrow involvement in patients with multiple myeloma (MM), in comparison with standard whole-body MRI protocol. Patients with biopsy-proven MM, who underwent a WBMRI with full-body coverage (from vertex to feet) were retrospectively enrolled. WBMRI images were independently evaluated by two expert radiologists, in terms of infiltration patterns (normal, focal, diffuse, and combined), according to location (the whole skeleton was divided into six anatomic districts: skull, spine, sternum and ribs, upper limbs, pelvis and proximal two-thirds of the femur, remaining parts of lower limbs) and lytic lesions number (<5, 5–20, and >20). The majority of patients showed focal and combined infiltration patterns with bone lesions predominantly distributed in the spine and pelvis. As skull and lower limbs are less frequently involved by focal bone lesions, excluding them from the standard MRI protocol allows to obtain a shorter protocol, maintaining a good diagnostic value.

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Comparison of contrast-enhanced CT, dual-layer detector spectral CT, and whole-body MRI in suspected metastatic breast cancer: a prospective diagnostic accuracy study

European Radiology ◽

10.1007/s00330-021-08041-2 ◽

2021 ◽

Author(s):

Thomas Winther Buus ◽

Finn Rasmussen ◽

Hanne Marie Nellemann ◽

Vibeke Løgager ◽

Anders Bonde Jensen ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast ◽

Whole Body ◽

Diagnostic Accuracy Study ◽

Spectral Ct ◽

Whole Body Mri ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Enhanced Ct ◽

Accuracy Study

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Incidental whole-body MRI evidence of COVID-19 in an asymptomatic patient in a high prevalence region

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-020-00288-x ◽

2020 ◽

Vol 51 (1) ◽

Cited By ~ 1

Author(s):

Valentina Angelini ◽

Alberta Villanacci ◽

Angelo Belotti ◽

Francesca Castagnoli ◽

Barbara Frittoli ◽

...

Keyword(s):

Asymptomatic Patient ◽

Whole Body ◽

Diagnostic Tools ◽

Historical Period ◽

Case Presentation ◽

Whole Body Mri ◽

High Prevalence ◽

Chest X Ray ◽

Full Knowledge ◽

Polymerase Chain

Abstract Background The purpose of this case report is to emphasize the importance of curing any clinical radiological elements in this historical period, especially in the area of endemic to coronavirus disease 19 (COVID-19) such as Lombardy and to stress the importance of the management of the asymptomatic patient, their crucial role in the spread of contagion. Case presentation We reported the case of incidental diagnosis of interstitial pneumonia by first finding on whole-body MR (WB-MR) in the patient affected by multiple myeloma (MM), with a negative respiratory symptoms at the time and with previous (1 month before) negative chest X-ray. The patient was promptly subjected to chest CT, which confirmed the suspicion of interstitial COVID-19 pneumonia and, in hospitalization, performed nasopharyngeal swabs for real-time polymerase chain reaction (RNA-PCR), with a doubtful outcome. Once the bacterial nature of the alterations was serologically and radiologically excluded, the patient was definitively diagnosed with COVID-19 and appropriately treated in hospitalization. Conclusion The clinical choices must, therefore, to make use of all the diagnostic tools available and full knowledge of the limitation of each of them.

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A Family With a Carotid Body Paraganglioma and Thyroid Neoplasias With a New SDHAF2 Germline Variant

Journal of the Endocrine Society ◽

10.1210/js.2018-00353 ◽

2019 ◽

Vol 3 (11) ◽

pp. 2151-2157

Author(s):

Katherine I Wolf ◽

Michelle F Jacobs ◽

Rohit Mehra ◽

Priya Begani ◽

Matthew S Davenport ◽

...

Keyword(s):

Succinate Dehydrogenase ◽

Carotid Body ◽

Follicular Adenoma ◽

Needle Aspiration ◽

Neck Mass ◽

Whole Body ◽

Whole Body Mri ◽

Pathogenic Variants ◽

Assembly Factor ◽

Associated Tumors

Abstract At least 30% of all pheochromocytomas (PCCs)/paragangliomas (PGLs) arise in patients with a germline predisposition syndrome. Variants in succinate dehydrogenase subunits A, B, C, and D (SDHA, SDHB, SDHC, and SDHD) are the most common pathogenic germline alterations. Few pathogenic variants have been reported in succinate dehydrogenase assembly factor 2 (SDHAF2). Here, we describe a 30-year-old female patient who presented with a left-sided neck mass, which was later characterized as a carotid body PGL. Genetic testing revealed a likely pathogenic SDHAF2 variant (c.347G>A;p.W116X). Two sisters carried the same pathologic variant, and screening protocols were recommended. Whole-body MRI revealed thyroid nodules; this testing was followed by fine-needle aspiration, which confirmed papillary thyroid carcinoma in one sister and a follicular adenoma in the other. The two sisters then underwent hemithyroidectomy and total thyroidectomy, respectively. Because evidence for pathogenic variants in SDHAF2 causing predisposition to PCC/PGL is limited, we discuss the challenges in mutational variant interpretation and decision making regarding screening for associated tumors.

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