Optimization of chlorogenic acid extraction from Elm tree, Ulmus minor Mill., fruits, using response surface methodology

2021 ◽  
Vol 256 ◽  
pp. 117773
Author(s):  
Mohammad Kazem Rofouei ◽  
Seyed Momen Hejazi Kojoori ◽  
Roudabeh Sadat Moazeni-Pourasil
Keyword(s):  
Response Surface Methodology ◽  
Chlorogenic Acid ◽  
Response Surface ◽  
Acid Extraction ◽  
Ulmus Minor

scholarly journals Optimization of Chlorogenic Acid Extraction from Green Coffee Beans Using Response Surface Methodology

2019 ◽  
Vol 2 (1) ◽  
pp. 332-342
Author(s):  
Ha Thi Ngoc Lai ◽  
Phuong Viet Nguyen ◽  
Hoai Thi Tran ◽  
Viet Ha Thi Dao ◽  
Ha Hai Hoang
Keyword(s):  
Response Surface Methodology ◽  
Chlorogenic Acid ◽  
Response Surface ◽  
Biological Properties ◽  
Acid Extraction ◽  
Green Coffee ◽  
Solid Ratio ◽  
Green Coffee Beans ◽  
Coffee Beans ◽  
Experimental Values

Chlorogenic acid is a natural antioxidant that is widespread in the plant kingdom and can be found at a high content level in green coffee beans. This secondary metabolite in green coffee beans has potent biological properties including antioxidant, anti-inflammatory, anti-cancer, anti-obesity, anti-hypertension, and anticonvulsant. In this study, the extraction of chlorogenic acid from Vietnamese green coffee beans was optimized using the response surface methodology. A second-order polynomial model with three important variables (liquid-to-solid ratio, temperature, and extraction time) was used. A rotatable central composite design consisting of 21 experimental runs with three replicates at the center point was applied to describe the experimental data. The experimental results properly conformed to the constructed model (R2 = 0.8549). The optimized conditions were as follows: 40% ethanol (v/v), a liquid-to-solid ratio of 11.77, at 85oC for 64 min. Four extractions were performed in parallel using the optimal conditions to validate the model. The experimental values highly agreed with the predicted value (P <0.05).

A Thermomechanical Preprocessing for Pectin Isolation from Orange Peel with Optimisation by Response Surface Methodology

2008 ◽  
Vol 4 (1) ◽  
Author(s):  
Sid-Ahmed Rezzoug ◽  
Zoulikha Maache-Rezzoug ◽  
Frédéric Sannier ◽  
Karim Allaf
Keyword(s):  
Response Surface Methodology ◽  
Moisture Content ◽  
Response Surface ◽  
Processing Time ◽  
Initial Moisture Content ◽  
Control Sample ◽  
Orange Peel ◽  
Response Surfaces ◽  
Acid Extraction ◽  
Pre Treatment

The instantaneous controlled pressure drop process (or D.I.C process: ``Détente Instantanée Contrôlée") was used as a pre-treatment prior to pectin acid extraction from orange peel. This process involves subjecting the orange peel for a short time to steam pressure varying from 100 to 700 kPa, followed by an instantaneous decompression to vacuum at 5 kPa. Effects of processing pressure, moisture content of peels before the thermomechanical treatment and processing time were examined with response surface methodology. The optimal conditions were determined and the response surfaces were plotted from the mathematical models. The Fisher test and p-value indicated that both processing pressure and moisture content of peels before the pre-treatment had a highly significant effect on the pectin yield. The quadratic effect of processing pressure as well as the interaction effects of the initial moisture content and processing time also had a significant effect on the response. Moreover, the kinetics of pectin extraction showed that after few minutes of hydrolysis, the yields of pectin were systematically higher than that of the control sample and this is important from industrial point of view because the hydrolysis of pectin is generally performed in 10-15 minutes.

Optimisation of pectin acid extraction from passion fruit peel (Passiflora edulisflavicarpa) using response surface methodology

2009 ◽  
Vol 44 (3) ◽  
pp. 476-483 ◽  
Author(s):  
Erika Kliemann ◽  
Karina Nunes de Simas ◽  
Edna R. Amante ◽  
Elane Schwinden Prudêncio ◽  
Reinaldo F. Teófilo ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Passion Fruit ◽  
Acid Extraction ◽  
Fruit Peel

scholarly journals Optimization of Baicalin, Wogonoside, and Chlorogenic Acid Water Extraction Process from the Roots of Scutellariae Radix and Lonicerae japonicae Flos Using Response Surface Methodology (RSM)

Processes ◽  
2019 ◽  
Vol 7 (11) ◽  
pp. 854
Author(s):  
Jichang Li ◽  
Rui Wang ◽  
Zunlai Sheng ◽  
Zhiyong Wu ◽  
Chunli Chen ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Chlorogenic Acid ◽  
Response Surface ◽  
Extraction Process ◽  
Extraction Time ◽  
Extraction Temperature ◽  
Single Factor ◽  
Solid Ratio ◽  
Scutellariae Radix ◽  
Optimized Conditions

In this study, a simultaneous water extraction process for baicalin, wogonoside, and chlorogenic acid has been optimized. The effect of extraction temperature, extraction time, and liquid–solid ratio was scrutinized by single factor experiments and further analyzed by Box–Behnken design (BBD) approach using response surface methodology (RSM). The extraction yield of investigated compounds was determined by high performance liquid chromatography (HPLC). Single-factor experiments and response surface analysis results revealed that the optimized conditions are: Liquid to solid ratio 25:1 (mL/g), extraction temperature 93 °C, extraction time 2.4 h, and the extraction cycle two. Importantly, it has been noted that under the above conditions, concentrations of baicalin, wogonoside, and chlorogenic were 0.078, 0.031, and 0.013 mg/mL, respectively, and the overall desirability (OD) value was 0.76 which was higher than the non-optimized conditions and the deviation from the predicted OD value was only 2.44%. Conclusively, it has been suggested that the model was stable and feasible, and fit for extraction of baicalin, wogonoside, and chlorogenic acid from Scutellariae Radix and Lonicerae (L.) japonicae Flos.

scholarly journals Reactive extraction of propionic acid using trioctylamine in 1–decanol by response surface methodology optimization technique

2020 ◽  
Vol 15 (2) ◽  
pp. 171-179 ◽  
Author(s):  
Victoria M Inyang ◽  
David Lokhat
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Propionic Acid ◽  
Acid Concentration ◽  
Optimization Technique ◽  
Statistical Design ◽  
Reactive Extraction ◽  
Acid Extraction ◽  
Process Variables ◽  
Optimum Conditions

Abstract Reactive extraction, a novel technique, was experimentally investigated for the removal of propionic acid, which is usually present in low concentrations in aqueous solutions. The experiments were conducted according to statistical design to develop an appropriate regression model. This was aimed at analyzing and optimizing the process variables and extraction efficiency for propionic acid reactive extraction from dilute aqueous streams using trioctylamine as extractant and 1-decanol as organic diluent. Response surface methodology in combination with Box–Behnken design involving 17 experimental runs was utilized for the propionic acid reactive extraction in this study. Three independent process variables were chosen as temperature (T), initial propionic acid concentration (CPAO) in the aqueous phase and trioctylamine composition (CTOA) in the organic phase. The statistical design analysis demonstrated that the propionic acid concentration and TOA composition had a significant effect while temperature had an insignificant effect on the response value as well as an interactive and quadratic effect on the response. The optimum conditions for propionic acid extraction were established as T  =  300.752 K, CTOA  =  18.252 %v/v, CPAO  =  0.408 kmol/m3. Under these optimum conditions, the propionic acid experimental extraction yield was 89.788 %, which was in close conformity with the predicted yield value of 91.939 %.

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