Identification of SARS-CoV-2 inhibitors from extracts of Houttuynia cordata Thunb

Anthracnose and blight were recorded on Houttuynia cordata Thunb. during April 2013 to December 2013. The isolated fungi from the symptomatic plants were identified as Alterneria alternata (Fr.) Keissler and Colletotrichum gloeosporoides (Penz.) Sacc. Ethanol leaf extracts of five plants viz.,Azadirachta indica L., Citrus limon L., Datura metel L., Sennaalata L. and Tagetes erecta L.were evaluated against the pathogenic fungi A. alternata and C. gloeosporoides at 5%, 10% and 20% concentrations in vitro. A. indica recorded as good inhibitor against the test fungi followed by C. limon, S. alata, D. metel and T.erecta. In vivo treatment also showed that A.indica is the most effective in controlling diseases at 10% concentration. The plants treated with A. indica were fresh and healthy up to one month of observation.J. Asiat. Soc. Bangladesh, Sci. 42(1): 41-48, June 2016

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Antioxidant Properties in Water and 70% Ethanol Extracts of Houttuynia Cordata Thunb

Journal of the Korea Academia-Industrial cooperation Society ◽

10.5762/kais.2013.14.10.5091 ◽

2013 ◽

Vol 14 (10) ◽

pp. 5091-5096 ◽

Cited By ~ 1

Author(s):

Hyung Soo Kim ◽

Mi-Ja Kim ◽

Chul Cheong ◽

Soon Ah Kang

Keyword(s):

Antioxidant Properties ◽

Houttuynia Cordata ◽

Ethanol Extracts ◽

Houttuynia Cordata Thunb

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Effects of Fermented Houttuynia cordata Thunb. on Diabetic Rats Induced by a High-Fat Diet with Streptozotocin and on Insulin Resistance in 3T3-L1 Adipocytes

Journal of Nutrition and Metabolism ◽

10.1155/2021/6936025 ◽

2021 ◽

Vol 2021 ◽

pp. 1-15

Author(s):

Wannachai Sakuludomkan ◽

Ranchana Yeewa ◽

Subhawat Subhawa ◽

Chakkrit Khanaree ◽

Arisa Imsumran Bonness ◽

...

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Cell Function ◽

Pancreatic Beta Cell ◽

Biological Properties ◽

Diabetic Rats ◽

Human Consumption ◽

High Fat ◽

Houttuynia Cordata ◽

Houttuynia Cordata Thunb

Houttuynia cordata Thunb. (plukaow in Thai language) exhibits several biological properties, and many products of H. cordata are therefore commercially available for human consumption, such as fermented juice or tablets as food supplements. This study aimed to investigate the antidiabetic effects of fermented H. cordata (HC) in high-fat diets and streptozotocin-induced diabetic rats. Oral administration of HC at a dose of 100 mg/kg.bw not only maintained bodyweight, food intake, and water consumption but also reduced blood glucose levels and improved glucose tolerance ability in the diabetic rats. Moreover, HC also decreased oxidative stress markers in serum and inflammatory-related mediators in pancreas tissues, indicating the improvement of pancreatic beta-cell function in the diabetic rats. In order to clarify the mechanism of HC, the effects of ethanolic extract of HC (HCE) on insulin resistance were determined in 3T3-L1 adipocytes. FHE could recover glucose uptake and decrease lipolysis in palmitate-treated 3T3-L1 adipocytes. Taken together, these results demonstrate that HC can improve diabetic symptoms by enhancing insulin sensitivity, reducing oxidative stress, and suppressing inflammation.

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Preliminary phytochemical screening and determination of total polyphenols and flavonoids content in the leaves of Houttuynia cordata Thunb

IOP Conference Series Materials Science and Engineering ◽

10.1088/1757-899x/736/6/062013 ◽

2020 ◽

Vol 736 ◽

pp. 062013

Author(s):

V T Nguyen ◽

V M Le ◽

T S Vo ◽

L M Bui ◽

H L T Anh ◽

...

Keyword(s):

Phytochemical Screening ◽

Total Polyphenols ◽

Houttuynia Cordata ◽

Houttuynia Cordata Thunb

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The Effects of Houttuynia cordata Thunb and Piper ribesioides Wall Extracts on Breast Carcinoma Cell Proliferation, Migration, Invasion and Apoptosis

Molecules ◽

10.3390/molecules25051196 ◽

2020 ◽

Vol 25 (5) ◽

pp. 1196 ◽

Cited By ~ 1

Author(s):

Subhawat Subhawa ◽

Teera Chewonarin ◽

Ratana Banjerdpongchai

Keyword(s):

Breast Cancer ◽

Cell Proliferation ◽

Cancer Cells ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Breast Cancer Cells ◽

Migration And Invasion ◽

Breast Cancer Cell Lines ◽

Houttuynia Cordata ◽

Houttuynia Cordata Thunb

Houttuynia cordata Thunb. (HCT) and Piper ribesioides Wall. (PR) are common herbs that are widely distributed throughout East Asia and possess various biological properties including anti-cancer effects. However, in breast cancer, their mechanisms responsible for anti-carcinogenic effects have not been clarified yet. In this study, the inhibitory effects of HCT and PR ethanolic extracts on breast cancer cell proliferation, migration, invasion and apoptosis were examined. In MCF-7 and MDA-MB-231 cells, HCT and PR extracts at low concentrations can inhibit colony formation and induce G1 cell cycle arrest by downregulating cyclinD1 and CDK4 expression. Additionally, HCT and PR extracts also decreased the migration and invasion of both breast cancer cell lines through inhibition of MMP-2 and MMP-9 secretion. Moreover, the induction of apoptosis was observed in breast cancer cells treated with high concentrations of HCT and PR extracts. Not only stimulated caspases activity, but HCT and PR extracts also upregulated the expression of caspases and pro-apoptotic Bcl-2 family proteins in breast cancer cells. Altogether, these findings provide the rationale to further investigate the potential actions of HCT and PR extracts against breast cancer in vivo.

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