The silence of sleep disorders. High prevalence of insomnia and obstructive sleep apnea symptoms in chronic hepatitis C infection

This chapter covers the relationship between sleep-related headaches and sleep disorders such as obstructive sleep apnea (OSA). Sleep apnea headache (SAH), a type of sleep-related headache that is classified in the International Classification of Headache Disorders, is a distinct subset of headache that is caused by OSA and occurs distinctly on awakening. Once recognized, treatment of OSA is associated with significant improvement in, and often resolution of, SAH. Given the high prevalence of headaches in the general population, sleep disorders must be considered in the evaluation of patients with headaches. A comprehensive sleep evaluation should be an integral part of the assessment of headache disorders. Sleep apnea headache and other types of headaches associated with sleep are reviewed in this chapter.

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The relationship of obstructive sleep apnea and cardiovascular diseases from the perspective of evidence-based medicine. Part 1

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2020-2405 ◽

2020 ◽

Vol 19 (3) ◽

pp. 2405

Author(s):

М. V. Agaltsov ◽

O. M. Drapkina

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Cardiovascular Diseases ◽

Sleep Disorders ◽

Developed Countries ◽

Obstructive Sleep ◽

Number Of Patients ◽

High Prevalence ◽

Relationship Of ◽

The Relationship

The results of prospective studies, meta-analyzes and systematic reviews on the associations of obstructive sleep apnea (OSA) with various cardiovascular diseases (CVD) were analyzed. Currently, the mechanisms related to high prevalence of breathing-related sleep disorders among population of economically developed countries are clear, and an increase in the number of OSA patients has been shown. The relationship between OSA and CVD has been widely confirmed in large cohort studies. The first review part discusses the relationship of hypertension (HTN) and various heart arrhythmias (atrial fibrillation (AF), bradyarrhythmias, premature ventricular contraction, sudden death during sleep) with breathing-related sleep disorders. These groups of cardiovascular disorders currently show the most proven relationship with sleep apnea. In addition to cross-sectional studies indicating the high prevalence of OSA in patients with HTN and AF, some observational studies indicate an increase in the number of patients with HTN and paroxysmal AF with history of untreated sleep apnea. An analysis of the current issues of OSA phenotypes (in particular, REM-related OSA in hypertensive patients) as the most unfavorable cardiovascular factors is carried out.

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Treatment and primary prevention in people who inject drugs for chronic hepatitis C infection: is elimination possible in a high-prevalence setting?

Addiction ◽

10.1111/add.13764 ◽

2017 ◽

Vol 112 (7) ◽

pp. 1290-1299 ◽

Cited By ~ 27

Author(s):

Ilias Gountas ◽

Vana Sypsa ◽

Olga Anagnostou ◽

Natasha Martin ◽

Peter Vickerman ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Primary Prevention ◽

Chronic Hepatitis C ◽

People Who Inject Drugs ◽

Hepatitis C Infection ◽

High Prevalence

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Fatigue in chronic hepatitis C infection a mixed method study

10.32920/ryerson.14645043.v1 ◽

2021 ◽

Author(s):

Dora Marta Zalai

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Sleep Disorders ◽

Chronic Hepatitis C ◽

Hcv Infection ◽

Hepatitis C Infection ◽

Cross Sectional ◽

Severe Fatigue ◽

Patient Reported ◽

Clinically Significant

Fatigue is a main patient reported outcome of chronic hepatitis C (HCV) infection; yet its contributors are unknown. Objectives: The study (1) evaluated fatigue predictors, (2) tested the mediating role of fatigue cognitions, (3) screened for sleep disorders, and (4) explored fatigue from patients’ perspectives. Participants: Both sexes (age>18 years, N = 115) with chronic HCV infection. Design: Cross-sectional. Results: Sixty percent reported severe fatigue (FSS≥4). Fatigue perceptions were the main predictors of fatigue (ß=.58, bias corrected CI = .070-.163). Fatigue perceptions mediated the relationship between comorbidities and fatigue. Half of the sample reported clinically significant symptoms of insomnia and/or sleep apnea. Eight main fatigue themes were endorsed by the participants. Conclusions: Fatigue and sleep disorders were clinically significant issues. Fatigue cognitions may contribute to severe fatigue outcomes. Significance: Integrating the findings into existing sleep and fatigue treatments could improve clinical outcomes.

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Fatigue in chronic hepatitis C infection a mixed method study

10.32920/ryerson.14645043 ◽

2021 ◽

Author(s):

Dora Marta Zalai

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Sleep Disorders ◽

Chronic Hepatitis C ◽

Hcv Infection ◽

Hepatitis C Infection ◽

Cross Sectional ◽

Severe Fatigue ◽

Patient Reported ◽

Clinically Significant

Fatigue is a main patient reported outcome of chronic hepatitis C (HCV) infection; yet its contributors are unknown. Objectives: The study (1) evaluated fatigue predictors, (2) tested the mediating role of fatigue cognitions, (3) screened for sleep disorders, and (4) explored fatigue from patients’ perspectives. Participants: Both sexes (age>18 years, N = 115) with chronic HCV infection. Design: Cross-sectional. Results: Sixty percent reported severe fatigue (FSS≥4). Fatigue perceptions were the main predictors of fatigue (ß=.58, bias corrected CI = .070-.163). Fatigue perceptions mediated the relationship between comorbidities and fatigue. Half of the sample reported clinically significant symptoms of insomnia and/or sleep apnea. Eight main fatigue themes were endorsed by the participants. Conclusions: Fatigue and sleep disorders were clinically significant issues. Fatigue cognitions may contribute to severe fatigue outcomes. Significance: Integrating the findings into existing sleep and fatigue treatments could improve clinical outcomes.

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Seizures, Stimulators, and Sleep, Oh My!

Sleep Disorders ◽

10.1093/med/9780190671099.003.0036 ◽

2019 ◽

pp. 629-641

Author(s):

Thapanee Somboon ◽

Nancy Foldvary-Schaefer

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Sleep Disorders ◽

Sleep Disorder ◽

Vagus Nerve Stimulation ◽

Sleep Complaints ◽

Obstructive Sleep ◽

High Prevalence ◽

The Impact

This chapter discusses the relationships between epilepsy and sleep disorders, and the impact of vagus nerve stimulation (VNS) on breathing in sleep. The prevalence of sleep disorders in people with epilepsy is twofold to threefold greater than estimates in the general population. Obstructive sleep apnea (OSA) is the most common sleep disorder investigated in epilepsy populations. Treatment of OSA has been shown to reduce seizures in some patients. In contrast, VNS therapy for epilepsy is associated with stimulation-induced respiratory changes in sleep, and in some cases it produces a clinical OSA syndrome. Given the high prevalence of sleep complaints among people with epilepsy, further research is warranted to confirm the role of sleep disorder therapies in epilepsy.

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