Characteristics of the upper respiratory tract in patients with acromegaly and correlations with obstructive sleep apnoea/hypopnea syndrome

2018 ◽  
Vol 48 ◽  
pp. 27-34 ◽  
Author(s):  
Xiaopeng Guo ◽  
Lu Gao ◽  
Ya'nan Zhao ◽  
Man Wang ◽  
Bo Jiang ◽  
...  
Author(s):  
S. P. Rubnikovich ◽  
I. S. Abelskaya ◽  
Yu. L. Denisova ◽  
S. V. Sirak ◽  
V. G. Shishov

The goal of the study was to analyze the upper respiratory tract condition indicators obtained by means of сone beam computed tomography (CBCT) for patients with dentition system diseases and obstructive sleep apnoea syndrome. Patients were divided into 3 study groups. The control group (the 1st study group) included the CBCT data obtained for 33 healthy patients. The 2nd study group included the CBCT data obtained for 136 patients with dentition system diseases (partial secondary edentia combined with chronic generalized periodontitis) without sleep disorder signs. The 3rd study group included the CBCT data obtained for 70 patients with partial secondary edentia combined with deep distal occlusion and obstructive sleep apnoea syndrome (OSAS). The CBCT method using the proposed diagnosis criteria made it possible to identify not only dentition system diseases, but also the dysfunction of the upper respiratory tract, in particular the OSAS causes. It was found with confidence that the reduction of the upper respiratory tract diagnostic indicators by 40 % or more, as compared to the regulatory indicators of healthy patients, led to the dysfunction of the respiratory tract and the apnoea development. Deep distal occlusion and secondary edentia conditioned the presence of the upper respiratory tract concave configuration and the localization of the minimum cross-sectional area below the occlusion plane, which increases the probability of development and progression of the obstructive sleep apnoea syndrome.


2019 ◽  
Vol 133 (2) ◽  
pp. 119-124
Author(s):  
R Y Hei ◽  
J Qin ◽  
S H Li

AbstractObjectiveTo examine the diagnostic value of hyoid cephalometrics in predicting retroglossal obstruction severity in patients with obstructive sleep apnoea hypopnea syndrome.MethodsNinety-six obstructive sleep apnoea hypopnea syndrome patients diagnosed by polysomnography were recruited. Polysomnography was repeated with a nasopharyngeal tube after eliminating rhinal and palatopharyngeal obstruction. Cervical vertebra lateral films and hyoid cephalometric measurements were obtained, including the distances of the hyoid to the: mental tubercle, prevertebral plane, mental tubercle coronal plane and mental tubercle horizontal plane.ResultsThe apnoea-hypopnoea index for nasopharyngeal tube polysomnography was significantly correlated with distances from the hyoid to: prevertebral plane (r = 0.350), coronal plane (r = 0.477), horizontal plane (r = 0.529) and mental tubercle (r = 0.560). It was strongly correlated with the hyoid to mental tubercle distance/hyoid to prevertebral plane distance value (r = 0.683), and (hyoid to coronal plane distance plus hyoid to horizontal plane distance)/hyoid to prevertebral plane distance value (r = 0.675).ConclusionObstructive sleep apnoea hypopnea syndrome patients with longer hyoid to mental tubercle distances, and/or more inferior and posterior hyoid bone position, are more prone to retroglossal stenosis and obstruction. Hyoid cephalometrics are valuable for predicting retroglossal obstruction severity.


World Science ◽  
2019 ◽  
Vol 2 (1(41)) ◽  
pp. 11-14
Author(s):  
Івчина Н. А.

The syndrome of obstructive sleep apnea/hypopnea is a common disease which is caused by obstruction of the upper respiratory tract. This condition is characterized by repeated pauses in breathing during sleep. It is usually associated with a decrease in blood oxygen saturation. Primary risk factors of obstructive sleep apnea/hypopnoea syndrome — age, being a male and the family anamnesis. To the minor factors contributing to development of obstructive sleep apnea/hypopnoea syndrome, adiposity, abusing alcohol, the smoking, a habitual snore, day drowsiness.The researchers are interested in this problem due to the fact that obstructive sleep apnea/hypopnea syndrome is an adverse consequence of cardiovascular diseases and sudden death. Objective. Determine the prevalence of this disease in the outpatient medical practiceMaterial and methods. Out-patient cardio-respiratory monitoring. Results and discussion. High incidence of disease in outpatient patients.


2019 ◽  
Vol 133 (05) ◽  
pp. 376-379 ◽  
Author(s):  
A Yenigun ◽  
N Degirmenci ◽  
S S Goktas ◽  
R Dogan ◽  
O Ozturan

AbstractObjectiveThis study investigated the relationship between disease severity and taste and smell functions in patients with obstructive sleep apnoea syndrome.MethodsA total of 65 patients with recurrent upper airway obstruction during sleep were included. Participants were divided into four groups according to apnoea-hypopnoea index, obtained on polysomnography. Smell and taste tests were performed on these patients.ResultsA significant difference was observed between the smell thresholds of the groups for the identification test (p = 0.016). In the taste test, significant differences were observed between the groups in terms of sweet, sour, salty and bitter taste test thresholds (p = 0.029, p = 0.0005, p = 0.001 and p = 0.017, respectively).ConclusionAs sleep apnoea severity increased (according to the apnoea-hypopnoea index) in obstructive sleep apnoea syndrome patients, the taste and smell thresholds decreased due to the effect of neuropathy and inflammation in the upper respiratory tract.


2005 ◽  
Vol 119 (4) ◽  
pp. 272-276 ◽  
Author(s):  
Kenny P Pang

A collapsible airway is often the common denominator in sleep-disordered breathing (SDB). The upper respiratory tract includes the nasal passage, nasopharynx, oral cavity, oropharynx, base-of-tongue region and the hypopharynx. It is believed that the highest amount of resistance in the upper respiratory tract is in the nasal cavities, and particularly the nasal valve. Most authors believe that when considering surgical options for patients with obstructive sleep apnoea (OSA) it is imperative to correct nasal pathology together with the other sites of airway obstruction. In this retrospective study, I sought to investigate the safety and efficacy of one-stage nasal and multi-level pharyngeal surgery. I compared two groups of patients: group 1, receiving one-stage nasal and multi-level pharyngeal surgery; and group 2, receiving only multi-level pharyngeal surgery. In group 1, nine out of 12 patients (75 per cent) met the criteria for surgical success, with a mean pre-operative apnoea-hypopnoea index (AHI) decreasing from 36.3 to 8.9 post-operatively (p<0.0002), while in group 2, 25 out of 40 patients met the surgical success criteria (62.5 per cent), with their mean AHI decreasing from 52.6 to 10.2 (p<0.0000). When comparing the surgical success rates between the two groups, it was not statistically significant, at p>0.106. There were no postoperative respiratory-related complications despite having bilateral nasal Merocel (tampon) packing in place (in group 1), and none of the patients in either group had any desaturation, hypoxaemia, apnoea or OSA-related complications. This series suggests that, with adequate post-operative monitoring, it is both safe and efficacious to perform both nasal and multi-level pharyngeal surgery in the one surgical session.


BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e030866 ◽  
Author(s):  
Fang Hua ◽  
Tingting Zhao ◽  
Tanya Walsh ◽  
Qiao Sun ◽  
Xiong Chen ◽  
...  

IntroductionObstructive sleep apnoea-hypopnea syndrome (OSAHS) is characterised by recurring episodes of complete or partial upper airway collapse during sleep. Persistent OSAHS is associated with long-term consequences, such as growth failure, cardiovascular and neurocognitive problems in children. Different from the aetiology of OSAHS in adults, the most common cause of paediatric OSAHS is adenotonsillar hypertrophy. Adenotonsillectomy (AT) has been recommended as the first-line treatment of paediatric OSAHS. Several studies have suggested that retarded growth caused by OSAHS can improve after AT during the prepubertal period. This review will systematically search and summarise the available evidence on the effects of AT on children’s growth.Methods and analysisWe will conduct electronic searches in MEDLINE (via PubMed), Embase, Google Scholar and the Cochrane Central Register of Controlled Trials for randomised controlled trials (RCTs) or cohort studies that included a control group. Additional records will be searched by checking the references included in the selected studies and relevant reviews. At least two authors will undertake selection of studies and data extraction independently and in duplicate. The Cochrane Risk of Bias tool and Risk Of Bias In Non-randomised Studies—of Interventions will be used to assess the risk of bias of RCT and cohort studies, respectively. A random-effects model will be used for meta-analyses. Data synthesis and other analyses will be carried out using the RevMan V.5.3 software. The Grades of Recommendation, Assessment, Development and Evaluation will be used to assess the quality of the supporting evidence behind each main comparison.Ethics and disseminationThere is no ethical issue in this systematic review given that we will only include published studies. The results will be disseminated via peer-reviewed publications and social networks.PROSPERO registration numberCRD42019125882


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