A facile, portable surface-enhanced Raman spectroscopy sensing platform for on-site chemometrics of toxic chemicals

2021 ◽  
pp. 130102
Author(s):  
Soogeun Kim ◽  
Jin-Ho Joo ◽  
Wansun Kim ◽  
Ayoung Bang ◽  
Hyung Woo Choi ◽  
...  
Nanoscale ◽  
2021 ◽  
Author(s):  
WONIL NAM ◽  
Wansun Kim ◽  
Wei Zhou ◽  
Eun-Ah You

We report a digital surface-enhanced Raman spectroscopy (SERS) sensing platform using the arrays of 3D nanolaminate plasmonic crystals (NLPC) coupled with Au nanoparticles and the digital (on/off) SERS signal analysis...


2017 ◽  
Author(s):  
Caitlin S. DeJong ◽  
David I. Wang ◽  
Aleksandr Polyakov ◽  
Anita Rogacs ◽  
Steven J. Simske ◽  
...  

Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: <i>Escherichia coli</i>, <i>Enterobacter cloacae</i>, and <i>Serratia marcescens</i>. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of <i>E. coli</i> in under 12 hrs, and detected <i>E. coli</i> from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 10<sup>3</sup> CFU/ml and 10<sup>4</sup> CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point-of-care settings for diagnosing bacterial infections.


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