Remission of type 2 diabetes in patients undergoing biliointestinal bypass for morbid obesity: a new surgical treatment

2016 ◽  
Vol 12 (4) ◽  
pp. 815-821 ◽  
Author(s):  
Gianmattia del Genio ◽  
Michel Gagner ◽  
Paolo Limongelli ◽  
Salvatore Tolone ◽  
Dimitri Pournaras ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Morbid Obesity ◽  
Surgical Treatment ◽  
Biliointestinal Bypass

TYPE 2 DIABETES MELLITUS REMISSION AND ITS PREDICTION AFTER TWO-STAGE SURGICAL TREATMENT OF PATIENTS WITH MORBID OBESITY

2019 ◽  
Vol 72 (5) ◽  
pp. 739-743
Author(s):  
Oleksandr Yu. Ioffe ◽  
Mykola S. Kryvopustov ◽  
Yuri A. Dibrova ◽  
Yuri P. Tsiura
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Morbid Obesity ◽  
Weight Loss ◽  
Type 2 Diabetes Mellitus ◽  
Surgical Treatment ◽  
Two Stage ◽  
C Peptide ◽  
Peptide Level

Introduction: Morbid obesity (MO) has a significant impact on mortality, health and quality of life of patients. Type 2 diabetes mellitus (T2DM) is a common comorbidity in patients with MO. The aim is to study T2DM remission and to develop a prediction model for T2DM remission after two-stage surgical treatment of patients with MO. Materials and methods: The study included 97 patients with MO. The mean BMI was 68.08 (95% CI: 66.45 - 69.71) kg/m2. 70 (72,2%) patients with MO were diagnosed with T2DM. The first stage of treatment for the main group (n=60) included the IGB placement, for the control group (n=37) - conservative therapy. In the second stage of treatment the patients underwent bariatric surgery. The study addresses such indicators as BMI, percentage of weight loss, percentage of excess weight loss, ASA physical status class, fasting glucose level, HbA1c, C-peptide. Results: Two-stage treatment of morbidly obese patients with T2DM promotes complete T2DM remission in 68.1% of patients. The risk prediction model for failure to achieve complete T2DM remission 12 months after LRYGB based on a baseline C-peptide level has a high predictive value, AUC = 0.84 (95% CI: 0.69-0.93), OR = 0.23 ( 95% CI: 0.08-0.67). Conclusions: Two-stage treatment of patients with MO promotes improvement of carbohydrate metabolism indicators. With a C-peptide level > 3.7 ng/ml, prediction of complete T2DM remission 12 months after Laparoscopic Roux-en-Y Gastric Bypass is favorable.

scholarly journals Incretins and their influence on the course of type 2 diabetes in patients with morbid obesity after bariatric oper

2012 ◽  
Vol 9 (2) ◽  
pp. 3-10 ◽  
Author(s):  
I I Dedov ◽  
Yu I Yashkov ◽  
E V Ershova
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Surgical Treatment ◽  
Metabolic Control ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Positive Effect

Most researchers support the important role of incretins, particularly glucagon-like peptide-1 in improving metabolic control in patients with type 2 diabetes after bariatric operations, mostly involving shunting. A positive effect of bariatric surgery for type 2 diabetes is known from numerous publications on the results of surgical treatment of morbid obesity and in this review we try to analyze the mechanisms of this effect.

78-OR: Glycaemia, Beta-Cell Function, and Incretin Hormones Post-OGTT One Year after Gastric Bypass and Sleeve Gastrectomy in Patients with Morbid Obesity and Type 2 Diabetes: An RCT (Oseberg Study)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 78-OR
Author(s):  
FARHAT FATIMA ◽  
JØRAN HJELMESÆTH ◽  
KARE I. BIRKELAND ◽  
HANNE L. GULSETH ◽  
JENS K. HERTEL ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Morbid Obesity ◽  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Incretin Hormones ◽  
One Year

scholarly journals Surgical treatment of a non-obese patient with type 2 diabetes – primary experience – a

2011 ◽  
Vol 2 ◽  
pp. 99-102
Author(s):  
Monika Proczko-Markuszewska ◽  
Łukasz Kaska ◽  
Tomasz Stefaniak ◽  
Zbigniew Śledziński ◽  
Andrzej J. Łachiński
Keyword(s):  
Type 2 Diabetes ◽  
Surgical Treatment ◽  
Obese Patient

Abstract 515: Bariatric Surgery Reverses Vascular Pathology in Mice With Morbid Obesity and Type 2 Diabetes

2018 ◽  
Vol 123 (Suppl_1) ◽  
Author(s):  
Yoonjung Park ◽  
Yong Wang1 ◽  
Hanrui Zhang ◽  
Kevin D Dellsperger ◽  
Barry J Potter ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Vascular Pathology
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