scholarly journals Vital personality scores and healthy aging: Life-course associations and familial transmission

2021 ◽  
pp. 114283
Author(s):  
Jasmin Wertz ◽  
Salomon Israel ◽  
Louise Arseneault ◽  
Daniel W. Belsky ◽  
Kyle J. Bourassa ◽  
...  
Keyword(s):  
Life Course ◽  
Healthy Aging ◽  
Familial Transmission

scholarly journals WORK, RETIREMENT, AND HEALTHY AGING: LIFE-COURSE ISSUES AND CHALLENGES

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 426-427
Author(s):  
C Mendes de Leon ◽  
K Henkens ◽  
U Bültmann
Keyword(s):  
Life Course ◽  
Healthy Aging

Major Discrimination Experiences, Education, and Genes

2019 ◽  
Vol 32 (7-8) ◽  
pp. 753-763
Author(s):  
Aniruddha Das
Keyword(s):  
Educational Attainment ◽  
Life Course ◽  
Mediation Analysis ◽  
Healthy Aging ◽  
Genetic Influences ◽  
Health And Retirement Study ◽  
Direct Effects ◽  
Polygenic Scores ◽  
Retirement Study

Objectives: Rather than acting as a buffer, educational attainment has a known positive linkage with major experiences of lifetime discrimination. Recently established genetic roots of education, then, may also influence such reports. The current study examined these patterns. Methods: Data were from the 2010 wave of the Health and Retirement Study. Polygenic scores indexed one’s genetic propensity for more education. Mediation analysis was through counterfactual methods. Results: Among Whites as well as Blacks, genetic antecedents of education also elevated discrimination reports. Part of this influence was channeled through education. At least among Whites, direct effects were also found. Discussion: Major discrimination experiences seem partly rooted in genes. Mechanisms are tentatively suggested. Direct genetic influences, in particular, indicate potential confounding of previously estimated linkages between discrimination and health or life course factors. Given the range of these prior results, and their implications for healthy aging, investigation of these possibilities is needed.

scholarly journals Do Life Course Physical Activity Profiles Reduce the Effects of Childhood Exposures on Cognition?

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 29-29
Author(s):  
Monica Williams-Farrelly ◽  
Jacqui Smith
Keyword(s):  
Physical Activity ◽  
Life Course ◽  
Healthy Aging ◽  
Latent Class ◽  
Mail Survey ◽  
Learning Problems ◽  
Average Reference ◽  
Curve Modeling ◽  
The Relationship ◽  
Retirement Study

Abstract Although physical activity throughout life is one of the most reliable predictors of healthy aging, can less consistent or favorable trajectories also improve cognition trajectories among older adults? Drawing from accumulation theories, we use longitudinal data from the Health and Retirement Study and Life History Mail Survey (N=9,309) to examine the early antecedents of cognitive decline and the extent to which different life course physical activity profiles can slow such a decline. Results from latent class analysis reveal seven distinct profiles: consistently low, consistently high, consistently average (reference), improvers, decliners, midlife motivators, and previously athletic “couch potatoes.” Growth curve modeling analyses show that membership in the consistently high class and midlife motivators were associated with better cognition initially and over time, with no difference between the two classes. Additionally, though poor health and learning problems in childhood were associated with worse initial cognition, physical activity does not mediate the relationship.

scholarly journals Life-Course Approach to Chronic Disease: The Active and Healthy Aging Perspective

2016 ◽  
Vol 64 (9) ◽  
pp. e59-e61 ◽  
Author(s):  
Angelo Scuteri ◽  
Fabrizia Lattanzio ◽  
Roberto Bernabei
Keyword(s):  
Chronic Disease ◽  
Life Course ◽  
Healthy Aging ◽  
Life Course Approach

Life course vaccination and healthy aging

2009 ◽  
Vol 21 (3) ◽  
pp. 258-263 ◽  
Author(s):  
Michael K. Gusmano ◽  
Jean-Pierre Michel
Keyword(s):  
Life Course ◽  
Healthy Aging

scholarly journals Vaccination as a preventative measure contributing to immune fitness

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Béatrice Laupèze ◽  
Giuseppe Del Giudice ◽  
Mark T. Doherty ◽  
Robbert Van der Most
Keyword(s):  
T Cells ◽  
Immune System ◽  
Immune Responses ◽  
Life Course ◽  
Healthy Aging ◽  
Epigenetic Clock ◽  
Immune Senescence ◽  
Preventative Measure ◽  
Prevention Of Infection ◽  
Trained Immunity

AbstractThe primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained immunity that re-programs innate cells to respond more efficiently to later, unrelated threats; slowing or reversing immune senescence by altering the epigenetic clock, and leveraging the pool of memory B and T cells to improve responses to new infections. Vaccines may exploit the plasticity of the immune system to drive longer-term immune responses that promote health at a broader level than just the prevention of single, specific infections. In this perspective, we discuss the concept of “immune fitness” and how to potentially build a resilient immune system that could contribute to better health. We argue that vaccines may contribute positively to immune fitness in ways that are only beginning to be understood, and that life-course vaccination is a fundamental tool for achieving healthy aging.

scholarly journals Health Care Professionals’ Perspectives on Life-Course Immunization: A Qualitative Survey from a European Conference

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 185
Author(s):  
Roy K. Philip ◽  
Alberta Di Pasquale
Keyword(s):  
Health Care ◽  
Life Course ◽  
Health Care Professionals ◽  
Healthy Aging ◽  
Healthy Lifestyle ◽  
Productive Aging ◽  
Vaccine Hesitancy ◽  
Audience Response ◽  
Vaccine Preventable Diseases ◽  
Immunization Strategies

Today, fewer children die each year from vaccine-preventable diseases than older adults. Health systems need new immunization strategies to tackle the burden of vaccine-preventable disease in an aging society. A life-course immunization (LCI) approach—which entails vaccination throughout an individual’s lifespan—enables adults to age with reduced risk to disease, thereby enabling healthy, active and productive aging. We conducted an audience response system (ARS)-based survey to investigate HCP perspectives on LCI in an opportunistic sample of 222 health care professionals (HCPs) from around the world who attended a European infectious diseases conference. Survey results show that LCI is a priority for HCPs (77.4%–88.6%), with most of them stating the need to frame it as a part of a healthy lifestyle (91.0%–100.0%). Insufficient LCI recommendations by vaccine providers (12.9%–33.3%) and governments (15.2%–41.9%) and insufficient targeted budget allocation (6.1%–21.7%) were indicated as the main barriers to implement LCI, ahead of vaccine hesitancy (9.7%–15.2%). HCPs were willing to make LCI a gateway to healthy aging but need support to work together with other stakeholders involved in the vaccination journey. This could be a step towards equitable health care for all of society.

scholarly journals Socioeconomic Inequalities in Mortality After Age 67: The Contribution of Psychological Factors

2021 ◽  
Vol 12 ◽  
Author(s):  
Marijke Veenstra ◽  
Gøril Kvamme Løset ◽  
Svein Olav Daatland
Keyword(s):  
Life Course ◽  
Perceived Control ◽  
Psychological Factors ◽  
Healthy Aging ◽  
Longitudinal Research ◽  
Socioeconomic Inequalities ◽  
Cox Proportional Hazards ◽  
Future Research ◽  
Primary Control

Diverging trends of longer lives and increased inequalities in age-at-death invite to updated research on late-life mortality. Earlier studies have identified health behavior, childhood, psychosocial, and material conditions as key determinants of life expectancy, but the role of psychological factors remains a topic of debate. The current study is framed in a life course developmental perspective and assesses the mediating role of secondary control strategies (subjective age) and primary control capacity (perceived control) to socioeconomic (wealth and education) inequality in mortality after age 67. Data are derived from the second wave of the Norwegian Life Course, Ageing and Generation study (N=1,432 and age 67–85). All in all, 366 deaths were observed over a mean follow-up of 9.6years. Perceived control was measured by the Pearlin and Schooler Mastery Scale. SA was measured with proportional discrepancy scores in felt age and ideal age. Stepwise Cox proportional hazards regression analyses were conducted to analyze the relative contribution of SES (education and accumulated wealth), felt age, and ideal age discrepancies and perceived control on 11-year mortality. Findings show that lower levels of wealth and perceived control independently predict increased elderly mortality over an 11-year period. Feeling younger and smaller ideal age discrepancies are positively associated with perceived control, but do not account for additional variability in longevity among older adults. Findings add to the interdisciplinary field of socioeconomic inequalities in elderly mortality and underline the specific importance of structural conditions (wealth) and the continued importance of (perceived) primary control capacity for longevity also after age 67. Future research may assess in more detail how wealth and perceived control complement each other in contributing to healthy aging and longevity, for example, by longitudinal research including the role of significant life events in the second half of life in different welfare state contexts.

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