Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin

Titanium and some of its alloys have received considerable attention for biomedical applications in recent years due to their excellent biocompatibility, high corrosion resistance and relatively low elastic modulus when compared to other metallic implant materials such as Co-Cr alloys and stainless steels. However, these alloys can still suffer from inadequate biocompatibility; lack of biological fixation and biomechanical mismatch with the properties of bone in vivo. In this study, a new biocompatible Ti alloy, Ti4Ta4Sn, consisting of alpha and beta phases was fabricated and their mechanical properties were investigated. Moreover, the Ti alloy was scaffolded into a porous structure using powder metallurgy with an architecture and elastic modulus mimicking those of cancellous bone. Cell culture results indicated that the new porous Ti alloy scaffold possesses excellent in vitro biocompatibility.

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Mesoporous surface topography promotes bone cell differentiation on low elastic modulus Ti–25Nb–25Zr alloys for bone implant applications

Journal of Alloys and Compounds ◽

10.1016/j.jallcom.2016.12.206 ◽

2017 ◽

Vol 707 ◽

pp. 220-226 ◽

Cited By ~ 9

Author(s):

Jean-Heng Chang ◽

Jeng-Fen Liu ◽

Ying-Sui Sun ◽

Chia-Ping Wu ◽

Her-Hsiung Huang ◽

...

Keyword(s):

Elastic Modulus ◽

Cell Differentiation ◽

Surface Topography ◽

Bone Cell ◽

Bone Implant ◽

Low Elastic Modulus ◽

Bone Cell Differentiation

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Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

Revista de Chimie ◽

10.37358/rc.17.12.6008 ◽

2018 ◽

Vol 68 (12) ◽

pp. 2925-2918

Author(s):

Gabriela Cioca ◽

Maricel Agop ◽

Marcel Popa ◽

Simona Bungau ◽

Irina Butuc

Keyword(s):

Drug Release ◽

Tannic Acid ◽

Release Rate ◽

Controlled Drug Release ◽

Toxicity Threshold ◽

Release System ◽

Liposomal Formulations ◽

Cross Linker ◽

Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

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Immobilization of laccase via cross-linked enzyme aggregates prepared using genipin as a natural cross-linker

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2020.12.136 ◽

2021 ◽

Vol 169 ◽

pp. 541-550

Author(s):

Jiyeon Hong ◽

Dahun Jung ◽

Saerom Park ◽

Yujin Oh ◽

Kyeong Keun Oh ◽

...

Keyword(s):

Cross Linker ◽

Natural Cross

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Cytocompatibility of Ti–xZr alloys as dental implant materials

Journal of Materials Science Materials in Medicine ◽

10.1007/s10856-021-06522-w ◽

2021 ◽

Vol 32 (5) ◽

Author(s):

Pinghua Ou ◽

Cong Hao ◽

Jue Liu ◽

Rengui He ◽

Baoqi Wang ◽

...

Keyword(s):

Elastic Modulus ◽

Pure Titanium ◽

Dead Cell ◽

Commercially Pure Titanium ◽

Modulus Ratio ◽

High Mechanical Strength ◽

Commercially Pure ◽

Low Elastic Modulus ◽

Cell Assays ◽

Osteogenic Induction

AbstractTi–xZr (x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti–xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic induction using CCK-8 and live/dead cell assays, electron microscopy, and real-time PCR. The Ti–xZr alloys were non-toxic and showed superior biomechanics compared to commercially pure titanium (cpTi). Ti–45Zr had the optimum strength/elastic modulus ratio and osteogenic activity, thus is a promising to used as dental implants.

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