Feasibility of using the homologous parietal peritoneum as a vascular substitute for venous reconstruction during abdominal surgery: From clinical practice to animal studies

Over the past few years, despite the lack of approved pediatric labelling, dexmedetomidine’s (DEX) use has become more prevalent in pediatric clinical practice as well as in research trials. Its respiratory-sparing effects and bioavailability by various routes are only some of the valued features of DEX. In recent years the potential organ-protective effects of DEX, with the possibility for preserving neurocognitive function, has put it in the forefront of clinical and bench research. This comprehensive review focused on the pediatric literature but presents relevant, supporting adult and animal studies in order to detail the recent growing body of literature around the pharmacology, end-organ effects, organ-protective effects, alternative routes of administration, synergetic effects, and clinical applications, with considerations for the future.

Download Full-text

Nutraceuticals in Thyroidology: A Review of in Vitro, and in Vivo Animal Studies

Nutrients ◽

10.3390/nu12051337 ◽

2020 ◽

Vol 12 (5) ◽

pp. 1337

Author(s):

Salvatore Benvenga ◽

Silvia Martina Ferrari ◽

Giusy Elia ◽

Francesca Ragusa ◽

Armando Patrizio ◽

...

Keyword(s):

Clinical Practice ◽

Animal Studies ◽

Experimental Studies ◽

Omega 3 ◽

Complementary Medicines ◽

Pathological Conditions ◽

Potential Risks ◽

Dietary Components

Nutraceuticals are defined as a food, or parts of a food, that provide medical or health benefits, including the prevention of different pathological conditions, and thyroid diseases, or the treatment of them. Nutraceuticals have a place in complementary medicines, being positioned in an area among food, food supplements, and pharmaceuticals. The market of certain nutraceuticals such as thyroid supplements has been growing in the last years. In addition, iodine is a fundamental micronutrient for thyroid function, but also other dietary components can have a key role in clinical thyroidology. Here, we have summarized the in vitro, and in vivo animal studies present in literature, focusing on the commonest nutraceuticals generally encountered in the clinical practice (such as carnitine, flavonoids, melatonin, omega-3, resveratrol, selenium, vitamins, zinc, and inositol), highlighting conflicting results. These experimental studies are expected to improve clinicians’ knowledge about the main supplements being used, in order to clarify the potential risks or side effects and support patients in their use.

Download Full-text

Venous reconstruction with the parietal peritoneum. The long results in 106 patients.

HPB ◽

10.1016/j.hpb.2019.10.1729 ◽

2019 ◽

Vol 21 ◽

pp. S265-S266

Author(s):

Safi Dokmak ◽

Béatrice Aussilhou ◽

Alain Sauvanet ◽

Olivier Soubrane

Keyword(s):

Parietal Peritoneum ◽

Venous Reconstruction

Download Full-text

Clinical Practice Guideline for Suctioning the Airway of the Intubated and Non-Intubated Patient

Canadian Respiratory Journal ◽

10.1155/2001/920160 ◽

2001 ◽

Vol 8 (3) ◽

pp. 163-181 ◽

Cited By ~ 16

Author(s):

Dina Brooks ◽

Cathy M Anderson ◽

Margaret A Carter ◽

Laurie A Downes ◽

Sean P Keenan ◽

...

Keyword(s):

Clinical Practice ◽

Clinical Practice Guideline ◽

Practice Guideline ◽

Animal Studies ◽

Evidence Based ◽

Respiratory Therapists ◽

Randomized Controlled ◽

Group Members ◽

Closed Systems ◽

Saline Instillation

OBJECTIVE: To provide physicians, physiotherapists, nurses and respiratory therapists with guidelines for the application of airway suctioning.DESIGN: This clinical practice guideline was developed using the model by Browman and colleagues. A working group of representatives from four professional colleges (nurses, physicians and surgeons, physiotherapists and respiratory therapists) and research experts was formed to conduct a systematic review, develop evidence-based recommendations and generate clinical practice guidelines. MEDLINE (1966 to 1998), CINAHL (1982 to 1997) and EMBASE (1974 to 1996) as well as the reference lists of identified articles were searched. Inclusion of articles was determined by at least two group members, and studies were classified according to type. Randomized, controlled; randomized; and nonrandomized crossover and comparative cohort trials were grouped by type of intervention and population for use in the development of recommendations. Other observational and animal studies dealing with adverse effects of suctioning were included in the review but were not used in the development of recommendations. Input on the evidence-based recommendations was sought and incorporated from members of all four professions and from experts on content and methodology.SETTING: Any setting (hospital or home) where suctioning is performed.POPULATION: Intubated and nonintubated adults, infants and children.RESULTS AND CONCLUSIONS: An attempt was made to develop recommendations in each of the subcategories of suctioning techniques addressed by at least one study. In some subcategories, definite recommendations were made (13 in adults, and three in children and infants); in other subcategories, insufficient evidence precluded recommendations. The recommendations addressed the following aspects of suctioning: preoxygenation, hyperinflation, insufflation, hyperoxygenation, hyperventilation, saline instillation, adaptor use, medication use, open and closed systems, and various types of catheters.

Download Full-text

Periconception Weight Loss: Common Sense for Mothers, but What about for Babies?

Journal of Obesity ◽

10.1155/2014/204295 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 11

Author(s):

Kristine Matusiak ◽

Helen L. Barrett ◽

Leonie K. Callaway ◽

Marloes Dekker Nitert

Keyword(s):

Weight Loss ◽

Clinical Practice ◽

Clinical Practice Guidelines ◽

Practice Guidelines ◽

Animal Studies ◽

Healthy Weight ◽

Increased Risk ◽

Periconceptional Period ◽

Nutritional Restriction ◽

Potential Risks

Obesity in the childbearing population is increasingly common. Obesity is associated with increased risk for a number of maternal and neonatal pregnancy complications. Some of these complications, such as gestational diabetes, are risk factors for long-term disease in both mother and baby. While clinical practice guidelines advocate for healthy weight prior to pregnancy, there is not a clear directive for achieving healthy weight before conception. There are known benefits to even moderate weight loss prior to pregnancy, but there are potential adverse effects of restricted nutrition during the periconceptional period. Epidemiological and animal studies point to differences in offspring conceived during a time of maternal nutritional restriction. These include changes in hypothalamic-pituitary-adrenal axis function, body composition, glucose metabolism, and cardiovascular function. The periconceptional period is therefore believed to play an important role in programming offspring physiological function and is sensitive to nutritional insult. This review summarizes the evidence to date for offspring programming as a result of maternal periconception weight loss. Further research is needed in humans to clearly identify benefits and potential risks of losing weight in the months before conceiving. This may then inform us of clinical practice guidelines for optimal approaches to achieving a healthy weight before pregnancy.

Download Full-text

Venous reconstruction with the parietal peritoneum. The long results in 90 patients.

HPB ◽

10.1016/j.hpb.2019.10.069 ◽

2019 ◽

Vol 21 ◽

pp. S539

Author(s):

S. Dokmak ◽

B. Aussilhou ◽

R. Chérif ◽

L. Barbier ◽

F. Cauchy ◽

...

Keyword(s):

Parietal Peritoneum ◽

Venous Reconstruction

Download Full-text

Venous reconstruction with the parietal peritoneum. The long results in 90 patients.

HPB ◽

10.1016/j.hpb.2019.10.1328 ◽

2019 ◽

Vol 21 ◽

pp. S992-S993

Author(s):

S. Dokmak ◽

B. Aussilhou ◽

R. Chérif ◽

L. Barbier ◽

F. Cauchy ◽

...

Keyword(s):

Parietal Peritoneum ◽

Venous Reconstruction

Download Full-text

DRENAJE QUIRÚRGICO EXTRAPERITONEAL DE ABSCESO DEL PSOAS: FUNDAMENTO ANATÓMICO. Drenaje quirúrgico extraperitoneal de absceso del psoas: Fundamento anatómico

Revista Argentina de Anatomía Clínica ◽

10.31051/1852.8023.v7.n2.14174 ◽

2016 ◽

Vol 7 (2) ◽

pp. 100-106

Author(s):

Alejandro M Russo ◽

Alejandra Garretano ◽

Andrés Pouy ◽

Gabriela Wagner ◽

Juan M Costa ◽

...

Keyword(s):

Clinical Practice ◽

Surgical Treatment ◽

Emergency Room ◽

Abdominal Wall ◽

Peritoneal Cavity ◽

Parietal Peritoneum ◽

Complete Relief ◽

Extraperitoneal Approach ◽

Lateral Abdominal Wall ◽

Formalin Fixed

El espacio extraperitoneal se encuentra delimitado por el peritoneo parietal y las paredes de la cavidad abdómino-pélvica. Al igual que la cavidad peritoneal este espacio puede ser asiento de diversas colecciones, como ser hematomas, tumores y supuración. Con el advenimiento de las nuevas técnicas de imagen, se ha contribuido no solo al mejor diagnóstico de estas patologías sino también a su mejor manejo. El objetivo de este trabajo es mostrar la anatomía del abordaje extraperitoneal del comparti-miento del psoas y su aplicación al tratamiento de un paciente. Para esto se utilizaron 5 cadáveres adultos fijados previamente en solución en base a formol. Se realizó disección bilateral de la pared antero-lateral del abdomen reclinando la bolsa peritoneal para a continuación abordar el compartimiento del músculo psoas. Este conocimiento fue utilizado en el tratamiento quirúrgico de una paciente que consultó por un absceso del compartimiento del psoas derecho. En las preparaciones cadavéricas, se observó cómo al rebatir el peritoneo parietal se expone la totalidad del compartimiento muscular del psoas. Este procedi-miento fue realizado a la paciente consiguiendo el drenaje completo de la cavidad abscedada, quien tuvo una buena evolución y fue dada de alta a los 7 días. Los hallazgos demuestran una vez más como el conocimiento anatómico sigue estando vigente en la práctica clínica, siendo la comprensión del espacio extraperitoneal fundamental no solo para el anatomista sino también para el cirujano. The retroperitoneal space is bounded by the parietal peritoneum and the posterior abdominal wall. Just like the peritoneal cavity, this region can host multiple effusions such as hematomas, tumors and suppuration. With the development of new radiological technics, both diagnosis and management of these conditions has improved. The purpose of this paper is to demonstrate the anatomy of the extraperitoneal approach of the psoas compartment and its application to a patient´s surgical treatment. For this purpose 5 formalin-fixed adult cadavers were used. Bilateral dissection of the antero-lateral abdominal wall was performed in every specimen. Once the parietal peritoneum was mobilized the psoas compartment was approached. This knowledge was used during the surgical treatment of a patient who attended to the emergency room with a right psoas compartment abscess. In the cadaveric specimens, the psoas muscular compartment was approached after mobilizing the parietal peritoneum medially. This procedure was carried out in the patient resulting in complete drainage of the purulent effusion. The patient had complete relief of the symptoms and was discharged 7 days after the procedure. These findings show that the anatomic knowledge is still important in clinical practice. Understanding the extraperitoneal space is crucial for both anatomists and surgeons.

Download Full-text