Essential oil-based dispersive liquid-liquid microextraction for the determination of N,N-dimethyltryptamine and β-carbolines in human plasma: A novel solvent-free alternative

Talanta ◽  
2021 ◽  
Vol 225 ◽  
pp. 121976
Author(s):  
Gabriela de Oliveira Silveira ◽  
Felipe Rebello Lourenço ◽  
Ana Miguel Fonseca Pego ◽  
Rafael Guimarães dos Santos ◽  
Giordano Novak Rossi ◽  
...  
Keyword(s):  
Essential Oil ◽  
Human Plasma ◽  
Solvent Free ◽  
Free Alternative ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Vortex-Assisted Dispersive Liquid–Liquid Microextraction Coupled with Deproteinization for Determination of Nateglinide in Human Plasma Using HPLC/UV

2020 ◽  
Author(s):  
Mohamed A Hammad ◽  
Amira H Kamal ◽  
Reham E Kannouma ◽  
Fotouh R Mansour
Keyword(s):  
Human Plasma ◽  
High Performance ◽  
Limit Of Detection ◽  
Signal To Noise Ratio ◽  
Cost Effective ◽  
Salt Addition ◽  
Relative Standard ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Abstract A validated method for preconcentration and determination of nateglinide in plasma was developed using vortex-assisted dispersive liquid–liquid microextraction. Different variables that affect extraction efficiency were studied and optimized, including type and volume of extractant, type and volume of disperser, pH of diluent, salt addition effect, centrifugation and vortex time. Nateglinide was extracted using 30 μL of 1-octanol as an extractant and 200 μL of methanol as a disperser. The enrichment factor reached 330 under the optimum conditions. High-performance liquid chromatography/ultraviolet was used for detection using phosphate buffer (pH 2.5, 10 mM): acetonitrile (45:55, v/v) as a mobile phase at a flow rate of 1 mL/min. The method was linear over the range of 50–20,000 ng/mL with a limit of detection of 15 ng/mL (signal-to-noise ratio = 3). Intra- and inter-day precision had %relative standard deviation <6% (n = 3) and the %recoveries were found to be between 102.5 and 105.9%. The proposed method is simple, sensitive, eco-friendly, cost-effective and powerful for microextraction of nateglinide from human plasma samples.

scholarly journals Development of an ionic liquid-based dispersive liquid–liquid microextraction method for the determination of nifurtimox and benznidazole in human plasma

Talanta ◽  
2013 ◽  
Vol 107 ◽  
pp. 95-102 ◽  
Author(s):  
J.M. Padró ◽  
M.E. Marsón ◽  
G.E. Mastrantonio ◽  
J. Altcheh ◽  
F. García-Bournissen ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Human Plasma ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Ultrasound-assisted extraction and dispersive liquid–liquid microextraction coupled with gas chromatography-mass spectrometry for the sensitive determination of essential oil components in lavender

2019 ◽  
Vol 11 (11) ◽  
pp. 1541-1550 ◽  
Author(s):  
Ping Chen ◽  
Bing Liu ◽  
Xin Liu ◽  
Jihong Fu
Keyword(s):  
Essential Oil ◽  
Gas Chromatography Mass Spectrometry ◽  
Ultrasound Assisted Extraction ◽  
Assisted Extraction ◽  
Sensitive Determination ◽  
Ultrasound Assisted ◽  
Oil Components ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Ultrasound-assisted extraction and dispersive liquid–liquid microextraction coupled with GC-MS for the sensitive determination of essential oil components in lavender.

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