Involvement of growth hormone (GH) and insulin-like growth factor (IGF) system in ovarian folliculogenesis

2009 ◽  
Vol 71 (8) ◽  
pp. 1193-1208 ◽  
Author(s):  
J.R.V. Silva ◽  
J.R. Figueiredo ◽  
R. van den Hurk
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Igf System ◽  
Ovarian Folliculogenesis

scholarly journals The Role of the Growth Hormone/Insulin-Like Growth Factor System in Visceral Adiposity

2017 ◽  
Vol 10 ◽  
pp. 117862641770399 ◽  
Author(s):  
Moira S Lewitt
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Visceral Obesity ◽  
Transgenic Animal ◽  
Visceral Adiposity ◽  
Future Research ◽  
Insulin Like Growth Factor ◽  
Igf System ◽  
Proliferation And Differentiation ◽  
Transgenic Animal Models

There is substantial evidence that the growth hormone (GH)/insulin-like growth factor (IGF) system is involved in the pathophysiology of obesity. Both GH and IGF-I have direct effects on adipocyte proliferation and differentiation, and this system is involved in the cross-talk between adipose tissue, liver, and pituitary. Transgenic animal models have been of importance in identifying mechanisms underlying these interactions. It emerges that this system has key roles in visceral adiposity, and there is a rationale for targeting this system in the treatment of visceral obesity associated with GH deficiency, metabolic syndrome, and lipodystrophies. This evidence is reviewed, gaps in knowledge are highlighted, and recommendations are made for future research.

scholarly journals Effects of Recombinant Human Insulin-Like Growth Factor I (IGF-I) Therapy on the Growth Hormone-IGF System of a Patient with a Partial IGF-I Gene Deletion

1999 ◽  
Vol 84 (5) ◽  
pp. 1611-1616 ◽  
Author(s):  
Cecilia Camacho-Hübner ◽  
Katie A. Woods ◽  
Farideh Miraki-Moud ◽  
Peter C. Hindmarsh ◽  
Adrian J. Clark ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Human Insulin ◽  
Gene Deletion ◽  
Insulin Like Growth Factor ◽  
Recombinant Human Insulin ◽  
Factor I ◽  
Igf System ◽  
Igf I ◽  
I Gene

Acute alterations in growth hormone-insulin-like growth factor axis in humans injected with endotoxin

1997 ◽  
Vol 273 (1) ◽  
pp. R371-R378 ◽  
Author(s):  
C. H. Lang ◽  
V. Pollard ◽  
J. Fan ◽  
L. D. Traber ◽  
D. L. Traber ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Maximal Increase ◽  
Igf System ◽  
Igf I ◽  
Igf Binding ◽  
Acute Changes ◽  
Transient Elevation ◽  
Igf Binding Protein

The purpose of the present study was to characterize the acute changes in the insulin-like growth factor (IGF) system in humans after administration of endotoxin (lipopolysaccharide; LPS). Escherichia coli LPS (4 ng/kg) was injected intravenously into healthy adults, and serial blood samples were collected for the next 5 h; subjects injected with saline served as time-matched controls. LPS administration resulted in a gradual decrease in the total extractable IGF-I concentration, which was reduced by approximately 20% over the final 2 h of the experiment; levels of free IGF-I were not significantly altered. LPS also produced a marked but transient elevation in growth hormone (GH) concentration. IGF-binding protein (BP)-1 levels were elevated more than fivefold 2 h after LPS injection, and thereafter levels gradually returned toward baseline. IGFBP-2 concentration also increased after LPS injection, but the maximal increase (approximately 50% above basal) was observed during the final 2 h of the protocol. In contrast, IGFBP-3 levels did not vary over the period examined in response to LPS, and there was no apparent increase in number of BP-3 proteolytic fragments. Cortisol levels were increased early and remained two- to threefold above baseline throughout the protocol. No significant alterations in serum concentration of glucose or insulin were noted. LPS also produced an early elevation in tumor necrosis factor and a later increase in interleukin-6. These data indicate that the acute changes in the GH-IGF axis in humans in response to LPS are comparable with those observed in humans in other traumatic conditions and in animal models of endotoxemia and infection.

Polycystic ovary syndrome and insulin-like growth factor (IGF) system.

2018 ◽  
Author(s):  
Ivica Lazurova ◽  
Jana Figurova ◽  
Zora Lazurova ◽  
Silvia Toporcerova ◽  
Miroslava Rabajdova ◽  
...  
Keyword(s):  
Growth Factor ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Insulin Like Growth Factor ◽  
Ovary Syndrome ◽  
Igf System

Consensus on the change of criteria for cure of acromegaly during the last decade

2011 ◽  
Vol 152 (18) ◽  
pp. 703-708 ◽  
Author(s):  
Gábor László Kovács ◽  
Judit Dénes ◽  
Erika Hubina ◽  
László Kovács ◽  
Sándor Czirják ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Disease Control ◽  
Short Communication ◽  
Consensus Statement ◽  
Diagnosis And Treatment ◽  
Clinical Aspects ◽  
Insulin Like Growth Factor ◽  
Criteria For Diagnosis ◽  
Definition Of

The Acromegaly Consensus Group redefined the consensus criteria for cure of acromegaly. 74 neurosurgeons and experienced endocrinologists summarized the latest results on diagnosis and treatment of acromegaly. In this consensus statement the reliable growth hormone and insulin-like growth factor-1 assays were established. Definition of disease control was discussed based on the available publications and evidence. This short communication summarizes the clinical aspects of consensus criteria for diagnosis and cure of acromegaly based on the original article. Orv. Hetil., 2011, 152, 703–708.

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