Background:
Busulfan (Bu) is an anticancer drug with a variety of adverse effects for
cancer patients. Oxidative stress has been considered as a common pathological mechanism and it
has a key role in the initiation and progression of liver injury by Bu.
Aim:
The study aimed to evaluate the antioxidant impact of L-Carnitine and Coenzyme Q10 and
their protective role against oxidative stress damage in liver tissues.
Methods and Material:
Thirty-six albino rats were divided equally into six groups. G1 (con), received
I.P. injection of DMSO plus 1 ml of distilled water daily by oral gavages; G2 (Bu), received
I.P. injection of Bu plus 1 ml of the distilled water daily; G3 (L-Car), received 1 ml of L-Car orally;
G4 (Bu + L-Car) received I.P. injection of Bu plus 1 ml of L-Car, G5 (CoQ10) 1 ml of CoQ10 daily;
and G6 (Bu + CoQ10) received I.P. injection of Bu plus 1 ml of CoQ10 daily.
Results:
The recent data showed that Bu induced significant (P<0.05) elevation in serum ALT,
AST, liver GSSG, NO, MDA and 8-OHDG, while showing significant (P<0.05) decrease in liver
GSH and ATP. On the other hand, L-Carnitine and Coenzyme Q10 ameliorated the negative effects
prompted by Bu. Immunohistochemical expression of caspase-3 in liver tissues reported pathological
alterations in Bu group while also showed significant recovery in L-Car more than CoQ10.
Conclusion:
L-Car, as well as CoQ10, can enhance the hepatotoxic effects of Bu by promoting energy
production in oxidative phosphorylation process and by scavenging the free radicals.
Comparison of coenzyme Q10 or fish oil for prevention of intermittent hypoxia-induced oxidative injury in neonatal rat lungs
