scholarly journals Adult exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of the hypothalamic–pituitary–testicular axis

Toxicology ◽  
2015 ◽  
Vol 329 ◽  
pp. 1-9 ◽  
Author(s):  
Patricia Wisniewski ◽  
Renata M. Romano ◽  
Marina M.L. Kizys ◽  
Kelen C. Oliveira ◽  
Teresa Kasamatsu ◽  
...  
Chemosphere ◽  
2018 ◽  
Vol 193 ◽  
pp. 365-375 ◽  
Author(s):  
Yingying Zhang ◽  
Yongjing Guan ◽  
Ting Zhang ◽  
Cong Yuan ◽  
Yan Liu ◽  
...  

2016 ◽  
Vol 26 (3) ◽  
pp. 180-188 ◽  
Author(s):  
Juan Li ◽  
Rui Mao ◽  
Qin Zhou ◽  
Ling Ding ◽  
Jin Tao ◽  
...  

2007 ◽  
Vol 115 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Milena Durando ◽  
Laura Kass ◽  
Julio Piva ◽  
Carlos Sonnenschein ◽  
Ana M. Soto ◽  
...  

2019 ◽  
Vol 26 (6) ◽  
pp. 5971-5982 ◽  
Author(s):  
Samuel Gbadebo Olukole ◽  
Damilare Olaniyi Lanipekun ◽  
Eunice Olufunke Ola-Davies ◽  
Bankole Olusiji Oke

1999 ◽  
Vol 30 (2) ◽  
pp. 130-139 ◽  
Author(s):  
S.Z. Cagen ◽  
J.M. Waechter ◽  
S.S. Dimond ◽  
W.J. Breslin ◽  
J.H. Butala ◽  
...  

2000 ◽  
Vol 74 (2) ◽  
pp. 92-98 ◽  
Author(s):  
Tatiana Goloubkova ◽  
Maria Flávia M. Ribeiro ◽  
Luciene P. Rodrigues ◽  
Ana L. Cecconello ◽  
Poli Mara Spritzer

Endocrinology ◽  
2014 ◽  
Vol 155 (2) ◽  
pp. 502-512 ◽  
Author(s):  
Marie Picot ◽  
Lydie Naulé ◽  
Clarisse Marie-Luce ◽  
Mariangela Martini ◽  
Kalina Raskin ◽  
...  

There are human reproduction concerns associated with extensive use of bisphenol A (BPA)-containing plastic and, in particular, the leaching of BPA into food and beverages. In this context, it remains unclear whether and how exposure to BPA interferes with the developmental organization and adult activation of male sexual behavior by testosterone. We evaluated the developmental and adult exposure to oral BPA at doses equivalent to the no-observed-adverse-effect-level (5 mg/kg body weight per day) and tolerable daily intake (TDI) (50 μg/kg body weight per day) on mouse sexual behavior and the potential mechanisms underlying BPA effects. Adult exposure to BPA reduced sexual motivation and performance at TDI dose only. Exposed males took longer to initiate mating and reach ejaculation despite normal olfactory chemoinvestigation. This deficiency was not restored by sexual experience and was associated with unchanged circulating levels of testosterone. By contrast, developmental exposure to BPA at TDI or no-observed-adverse-effect-level dose did not reduce sexual behavior or alter the neuroanatomical organization of the preoptic area. Disrupting the neural androgen receptor resulted in behavioral and neuroanatomical effects similar to those induced by adult exposure to TDI dose. Moreover, adult exposure of mutant males to BPA at TDI dose did not trigger additional alteration of sexual behavior, suggesting that BPA and neural androgen receptor mutation share a common mechanism of action. This shows, for the first time, that the neural circuitry underlying male sexual behavior is vulnerable to chronic adult exposure to low dose of BPA and suggests that BPA could act in vivo as an antiandrogenic compound.


PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73584 ◽  
Author(s):  
Beatriz Castro ◽  
Pilar Sánchez ◽  
Jesús M. Torres ◽  
Esperanza Ortega

2020 ◽  
Vol 1 (1) ◽  
pp. 11-17
Author(s):  
Tomas Jambor ◽  
Eva Kovacikova

Infertility is widespread problem defined as the inability to conceive after one year of unprotected intercourse. One of the most notable factors causing this status is the exposure to environmental contaminants. It is now recognized that many contaminants present in the environment have the ability to interfere in the action of hormones and therefore are termed endocrine disruptors (EDs). Some of these compounds are present in nature, but the majority are artificial and released into the environment by the human activities without any prior knowledge of their impact on ecosystems, animal welfare, or wildlife and human health. Many epidemiological studies have reported a radical growth in the incidence of male infertility, accompanied by decreasing sperm quality, decline in spermatozoa motility, defect in Leydig cell morphology, insufficient activity of steroidogenesis and spermatogenesis. The similar situation was observed in female, when the increased risk for endometriosis, reproductive and other endocrine-related cancer, impaired oocytes, ovarian dysfunction, or irregular menstrual cycle was confirmed. All mentioned consequences have been associated with increasing concentration of bisphenol A (BPA) in the environment. Humans are exposed to BPA not only through specific occupational circumstance, but nowadays more generally also from the ordinary day-to-day domestic and workplace lifestyles. Almost 3.4 million tons per year of BPA is used in a variety common product such as food packaging, household products, epoxy resins, dental sealants and many others. Under these endpoints, apprehensions about the reproductive dysfunctions associated with BPA action are unquestionable. In this review, we address the topic of BPA effects on reproductive function in males and females and emphasize its effects on overall health. A considerably more detailed and systematic research in EDs toxicology is required for a better understanding of risks associated with exposure to environmental toxicants.


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