scholarly journals Protective role of Emblica officinalis hydro-ethanolic leaf extract in cisplatin induced nephrotoxicity in Rats

2018 ◽  
Vol 5 ◽  
pp. 270-277 ◽  
Author(s):  
Rupal Purena ◽  
Rohit Seth ◽  
Renu Bhatt
Keyword(s):  
Leaf Extract ◽  
Protective Role ◽  
Emblica Officinalis ◽  
Ethanolic Leaf Extract

scholarly journals Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae)

2018 ◽  
Vol 29 (6) ◽  
pp. 609-619 ◽  
Author(s):  
Lucky Legbosi Nwidu ◽  
Yibala I. Oboma ◽  
Ekramy Elmorsy ◽  
Wayne Grant Carter
Keyword(s):  
Carbon Tetrachloride ◽  
Leaf Extract ◽  
Protective Role ◽  
Lipid Peroxidation Product ◽  
Hematological Indices ◽  
Hepatocellular Damage ◽  
Antioxidant Parameters ◽  
Mechanistic Basis ◽  
Histopathological Studies

Abstract Background Glyphae brevis leaf is reported in ethnomedicine as a treatment for hepatitis and jaundice; however, no studies have hitherto investigated the mechanistic basis of these claims. Methods A hepato-protective role of G. brevis hydromethanolic (GBH) leaf extract was established against carbon tetrachloride (CCl4)-induced hepatotoxicity. Twenty-four hours after a CCl4 challenge, rats were sacrificed and serum hematological indices, lipid profile, and biochemical parameters were determined. The antioxidant enzymes parameters (glutathione, catalase, and superoxide dismutase) and lipid peroxidation product (thiobarbituric reactive substances) levels in liver homogenates were evaluated. Changes in the liver cyto-architecture of different treatment groups were also investigated. Results The GBH extract produced no significant impact on weight and hematological indices. Intoxication with CCl4 significantly (p<0.001–0.05) increased total cholesterol (TC) and low-density lipoproteins (LDL) compared with control rats. Pretreatment with GBH leaf extract significantly reduced triglycerides, TC, and LDL to approaching control levels (p<0.001–0.05). The GBH leaf extract significantly alleviated CCl4-induced elevation of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and the CCl4-induced depression of total protein, and albumin. Liver antioxidant parameters were significantly increased in plant extract-treated rats, and this antagonized the pro-oxidant effect of CCl4. Histopathological studies also supported a hepato-protective effect of GBH. Collectively, the GBH leaf extract alleviated the CCl4-induced hepatotoxicity through improvement of innate antioxidant enzyme levels and lipid metabolism and stabilized the hepatocyte cyto-architecture of intoxicated rats. Conclusions This study establishes the ethnomedicinal role of G. brevis leaf in hepatitis and the mechanistic basis of hepato-protection against CCl4-induced hepatotoxicity.

Protective Role of Syzygium Cymosum Leaf Extract Against Carbofuran-Induced Hematological and Hepatic Toxicities

2019 ◽  
Vol 32 (8) ◽  
pp. 1619-1629 ◽  
Author(s):  
Tania Binte Wahed ◽  
Milon Mondal ◽  
Mohammad Asikur Rahman ◽  
Md. Sakib Hossen ◽  
Nikhil Chandra Bhoumik ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Protective Role

scholarly journals Anti-Inflammatory Potential of Ethanolic Leaf Extract ofEupatorium adenophorumSpreng. Through Alteration in Production of TNF-α, ROS and Expression of Certain Genes

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Ashim K. Chakravarty ◽  
Tamal Mazumder ◽  
Shankar N. Chatterjee
Keyword(s):  
Leaf Extract ◽  
Inflammatory Cytokine ◽  
Delayed Type Hypersensitivity ◽  
Tissue Destruction ◽  
Eupatorium Adenophorum ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
First Time ◽  
Ethanolic Leaf Extract

Search for a novel anti-inflammatory agent from a herbal source, such asEupatorium adenophorumSpreng., a plant from the Eastern Himalayas, is of prime interest in the present investigation. Inflammation causes tissue destruction and development of diseases such as asthma, rheumatoid arthritis, and so forth. The ethanolic leaf extract ofE. adenophorum(EEA) was administered intravenously and in other cases topically at the site of delayed type hypersensitivity (DTH) reaction in mouse foot paw induced with dinitrofluorobenzene. EEA can effectively inhibit DTH reaction and bring back normalcy to the paw much earlier than the controls. Efficacy of EEA on regulatory mechanisms for inflammation has also been considered. Intravenous administration of EEA increased the number of CD4+T cells in spleen and tumor necrosis factor (TNF)-αin serum of DTH mice. Initially it was difficult to reconcile with the anti-inflammatory role of EEA and simultaneous induction of TNF-α, an established pro-inflammatory cytokine. EEA induces higher expression ofTNF-αgene and amount of the cytokine in serum. We discussed the other role of TNF-α, its involvement in repairing tissue damage incurred in course of inflammatory reaction. EEA also induces TGF-βencoding a cytokine involved in tissue repair mechanism. EEA inhibits expression of another pro-inflammatory cytokine geneIL-1βand downregulates cycloxygenase 2 (COX2) gene responsible for metabolism of inflammatory mediators like prostaglandins. Furthermore, anti-inflammatory role of EEA is also revealed through its inhibition of hydroxyl radical generation. Notably EEA does not necessarily affect the expression of other inflammation-related genes such asIL-6, IL-10andIKK. The present study reports and analyzes for the first time the anti-inflammatory property of the leaf extract ofE. adenophorum.

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