scholarly journals The induction of a mesenchymal phenotype by platelet cloaking of cancer cells is a universal phenomenon

2021 ◽  
Vol 14 (12) ◽  
pp. 101229
Author(s):  
Cathy D. Spillane ◽  
Niamh M. Cooke ◽  
Mark P. Ward ◽  
Dermot Kenny ◽  
Gordon Blackshields ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mesenchymal Phenotype

scholarly journals Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs

2021 ◽  
Vol 7 (9) ◽  
pp. eabb0737
Author(s):  
Zhengnan Yang ◽  
Wei Wang ◽  
Linjie Zhao ◽  
Xin Wang ◽  
Ryan C. Gimple ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Ovarian Cancer Cells ◽  
Mesenchymal Phenotype ◽  
Ovarian Cancers ◽  
Novel Approach

Ovarian cancer represents a highly lethal disease that poses a substantial burden for females, with four main molecular subtypes carrying distinct clinical outcomes. Here, we demonstrated that plasma cells, a subset of antibody-producing B cells, were enriched in the mesenchymal subtype of high-grade serous ovarian cancers (HGSCs). Plasma cell abundance correlated with the density of mesenchymal cells in clinical specimens of HGSCs. Coculture of nonmesenchymal ovarian cancer cells and plasma cells induced a mesenchymal phenotype of tumor cells in vitro and in vivo. Phenotypic switch was mediated by the transfer of plasma cell–derived exosomes containing miR-330-3p into nonmesenchymal ovarian cancer cells. Exosome-derived miR-330-3p increased expression of junctional adhesion molecule B in a noncanonical fashion. Depletion of plasma cells by bortezomib reversed the mesenchymal characteristics of ovarian cancer and inhibited in vivo tumor growth. Collectively, our work suggests targeting plasma cells may be a novel approach for ovarian cancer therapy.

scholarly journals Mesenchymal Phenotype Predisposes Lung Cancer Cells to Impaired Proliferation and Redox Stress in Response to Glutaminase Inhibition

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115144 ◽  
Author(s):  
Danielle B. Ulanet ◽  
Kiley Couto ◽  
Abhishek Jha ◽  
Sung Choe ◽  
Amanda Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Redox Stress ◽  
Mesenchymal Phenotype

scholarly journals High Skp2 expression is associated with a mesenchymal phenotype and increased tumorigenic potential of prostate cancer cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Šárka Šimečková ◽  
Zuzana Kahounová ◽  
Radek Fedr ◽  
Ján Remšík ◽  
Eva Slabáková ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Mesenchymal Phenotype ◽  
Skp2 Expression ◽  
Tumorigenic Potential

Abstract 235: AXL inhibition leads to a reversal of a mesenchymal phenotype sensitizing cancer cells to targeted agents and immuno-oncology therapies

2016 ◽  
Author(s):  
Katherine K. Soh ◽  
Wontak Kim ◽  
Ye Sol Lee ◽  
Peter Peterson ◽  
Adam Siddiqui-Jain ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Targeted Agents ◽  
Mesenchymal Phenotype

scholarly journals AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt–MDM2–Foxo3a Signaling Axis

2014 ◽  
Vol 74 (17) ◽  
pp. 4783-4795 ◽  
Author(s):  
Chih-Chien Chou ◽  
Kuen-Haur Lee ◽  
I-Lu Lai ◽  
Dasheng Wang ◽  
Xiaokui Mo ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mesenchymal Phenotype ◽  
Signaling Axis

scholarly journals Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
José Esparza-López ◽  
Juan Francisco Alvarado-Muñoz ◽  
Elizabeth Escobar-Arriaga ◽  
Alfredo Ulloa-Aguirre ◽  
María de Jesús Ibarra-Sánchez
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Primary Breast Cancer ◽  
Breast Cancer Cells ◽  
Mesenchymal Phenotype

scholarly journals TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells

2019 ◽  
Vol 10 (2) ◽  
Author(s):  
Sabrina Rivero ◽  
Elena Gómez-Marín ◽  
José A. Guerrero-Martínez ◽  
Jorge García-Martínez ◽  
José C. Reyes
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mesenchymal Phenotype

scholarly journals TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype

2008 ◽  
Vol 113 (2) ◽  
pp. 217-230 ◽  
Author(s):  
Monzur Rahman ◽  
Sean R. Davis ◽  
Janet G. Pumphrey ◽  
Jing Bao ◽  
Marion M. Nau ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Mesenchymal Phenotype

scholarly journals Ovarian Cancer Cells in Ascites Form Aggregates That Display a Hybrid Epithelial-Mesenchymal Phenotype and Allows Survival and Proliferation of Metastasizing Cells

2022 ◽  
Vol 23 (2) ◽  
pp. 833
Author(s):  
Sonia Capellero ◽  
Jessica Erriquez ◽  
Chiara Battistini ◽  
Roberta Porporato ◽  
Giulia Scotto ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Single Cells ◽  
Ovarian Cancer Cells ◽  
Mesenchymal Phenotype ◽  
3D Structures ◽  
Multicellular Aggregates ◽  
Ovarian Cancer Cell Lines ◽  
Ascites Form ◽  
Peritoneal Lining

Peritoneal metastases are the leading cause of morbidity and mortality in ovarian cancer. Cancer cells float in peritoneal fluid, named ascites, together with a definitely higher number of non neo-neoplastic cells, as single cells or multicellular aggregates. The aim of this work is to uncover the features that make these aggregates the metastasizing units. Immunofluorescence revealed that aggregates are made almost exclusively of ovarian cancer cells expressing the specific nuclear PAX8 protein. The same cells expressed epithelial and mesenchymal markers, such as EPCAM and αSMA, respectively. Expression of fibronectin further supported a hybrid epithelia-mesenchymal phenotype, that is maintained when aggregates are cultivated and proliferate. Hematopoietic cells as well as macrophages are negligible in the aggregates, while abundant in the ascitic fluid confirming their prominent role in establishing an eco-system necessary for the survival of ovarian cancer cells. Using ovarian cancer cell lines, we show that cells forming 3D structures neo-expressed thoroughly fibronectin and αSMA. Functional assays showed that αSMA and fibronectin are necessary for the compaction and survival of 3D structures. Altogether these data show that metastasizing units display a hybrid phenotype that allows maintenance of the 3D structures and the plasticity necessary for implant and seeding into peritoneal lining.

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