Guidelines for Maintenance of Adult Patients With Brain Death and Potential for Multiple Organ Donations: The Task Force of the Brazilian Association of Intensive Medicine the Brazilian Association of Organs Transplantation, and the Transplantation Center of Santa Catarina

2012 ◽  
Vol 44 (8) ◽  
pp. 2260-2267 ◽  
Author(s):  
G.A. Westphal ◽  
M. Caldeira Filho ◽  
A. Fiorelli ◽  
K.D. Vieira ◽  
V. Zaclikevis ◽  
...  
PEDIATRICS ◽  
1995 ◽  
Vol 96 (3) ◽  
pp. 518-520
Author(s):  
Ken Okamoto ◽  
Tsuyoshi Sugimoto

It is generally assumed that the child's brain is more resistant to insults leading to death. Current guidelines for brain death, therefore, avoid application of these standards to young children.1 The determination of brain death in children, however, has become increasingly important, and different sets of new guidelines for children have been recently published.1-4 Especially, the recommendations of a special task force, consisting of representatives from neurologic organizations and the American Academy of Pediatrics, were published in five major journals.4 Those primary distinctions were three separate longer observation periods depending on the child's age and the necessity for two corroborating electroencephalograms (EEGs) or one EEG with a corroborating cerebral radionucleotide angiogram.


Author(s):  
Kelser De Souza Kock ◽  
Mariana Gabriela Santana ◽  
Silvia Catarine Da Silva ◽  
Samuel Brida Andrade ◽  
Edvan Nunes dos Santos

Objetivo: Analisar o perfil epidemiológico e as disfunções orgânicas e eletrolíticas em potenciais doadores de órgãos. Métodos: Estudo transversal, descritivo. Foram selecionados pacientes com morte encefálica, na Unidade de Terapia Intensiva de um hospital do sul do estado de Santa Catarina, no período de 2014 a 2016. Resultados: Foram avaliados 64 indivíduos, com prevalência do sexo masculino (56,3%), com mediana de 51,5 anos de idade. O Acidente Vascular Cerebral mostrou-se como a principal causa de diagnóstico de morte encefálica, em 42% dos casos. Houve doação em 45% dos pacientes, totalizando 120 órgãos ou tecidos doados, destacando-se o globo ocular, os rins e o fígado. Nos exames laboratoriais os pacientes apresentaram uma mediana de 147,0 mmol/L para o sódio, 4,2 mmol/L para o potássio e 246,0 mg/dL para a glicose. O escore de SOFA apresentou mediana geral 6, com maiores valores nos SOFA cardiovascular e respiratório (p<0,001) em relação aos SOFA renal, hematológico e hepático. Conclusão: O perfil epidemiológico dos potenciais doadores é similar a outros estudos. Quanto às disfunções orgânicas eletrolíticas e metabólicas, foram evidenciados distúrbios de hipernatremia e hiperglicemia. As disfunções orgânicas significativas identificadas pelo SOFA foram nos sistemas cardiovascular e respiratório. Neste sentido, especial atenção deve ser dada a estes sistemas para adequada manutenção do potencial doador.Descritores: Morte encefálica, Obtenção de tecidos e órgãos, Eletrólitos, Escores de disfunção orgânicaABSTRACT:Objective: To analyze the epidemiological profile and the organ and electrolytics dysfunctions in potential organ donors. Methods: Cross-sectional, descriptive study. We selected patients with brain death at the Intensive Care Unit of a hospital in the southern state of Santa Catarina, from 2014 to 2016. Results: We evaluated sixty-six individuals, with a prevalence of males (56.3%), with a median age of 51.5 years. The Cerebral Vascular Accident was the main cause of brain death’s diagnosis (42%). There was donation in 45% of the patients, totaling 120 organs and tissue donated, standing out the eyeball, kidneys and liver. In the laboratory tests the patients had a median of 147.0 mmol / L for sodium, 4.2 mmol / L for potassium and 246.0 mg / dL for glucose. The SOFA score presented general median 6, with higher values in cardiovascular and respiratory SOFA (p <0.001) in relation to renal, hematological and hepatic SOFA. Conclusion: The epidemiological profile of potential donors is similar to other studies. As for the organic and metabolic dysfunctions, disorders of hypernatremia and hyperglycemia were evidenced. The significant organic dysfunctions identified by SOFA were in the cardiovascular and respiratory systems. In this sense, special attention should be given to these systems for adequate maintenance of the potential donor.Keywords: Brain death, Tissue and organ procurement, Electrolytes, Organ dysfunction scores


PEDIATRICS ◽  
1989 ◽  
Vol 83 (4) ◽  
pp. 629-629
Author(s):  
RICHARD M. NARKEWICZ

In 1986, a task force was impaneled consisting of representatives from a number of legal and medical disciplines, including two representatives from the American Academy of Pediatrics, to examine the issue of brain death in children. This consortium developed a consensus report which was published in Pediatrics (1987;80:298-300). This report, however, does not represent Academy policy and should not be construed as such. This material has been referenced subsequently, most recently in the August (1988) issue of Pediatrics, with the inference that it represents the Academy's position. In summary, the guidelines issued by the Task Force have provided the medical and legal communities with useful information on a sensitive issue, but it should be reiterated that they do not represent an official policy of the American Academy of Pediatrics.


2002 ◽  
Vol 19 (2) ◽  
pp. 324-342 ◽  
Author(s):  
James L. Bernat

Notwithstanding these wise pronouncements, my project here is to characterize the biological phenomenon of death of the higher animal species, such as vertebrates. My claim is that the formulation of “whole-brain death” provides the most congruent map for our correct understanding of the concept of death. This essay builds upon the foundation my colleagues and I have laid since 1981 to characterize the concept of death and refine when this event occurs. Although our society's well-accepted program of multiple organ procurement for transplantation requires the organ donor first to be dead, the concept of brain death is not merely a social contrivance to permit us to obtain the benefits of organ procurement. Rather, the concept of whole-brain death stands independently as the most accurate biological representation of the demise of the human organism.


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